Intraparenchymal administration of interleukin-1β induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain

Journal of Neuroimmunology

Volumn 148, Issue 1-2, 2004, Pages 32-40

  Moore, Amy H ^a,b   Olschowka, John A ^a   O'Banion, M Kerry ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b SANTA CLARA UNIVERSITY   (United States)

Author keywords

COX 2; Neuroinflammation; NS 398; Prostaglandin E2 synthase

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INTERLEUKIN 1BETA; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN MEMBRANE; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

EID: 1242340280     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2003.11.001     Document Type: Article

References (43)

1. Basu A., Krady J.K., O'Malley M., Styren S.D., DeKosky S.T., Levinson S.W. The type-1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatroy mediators in response to brain injury. J. Neurosci. 22:2002;6071-6082.
2. Borriello F., Leferer J. Construction of RT-PCR mimics. Biotechniques. 19:1995;580-584.
3. Cao C., Matsumura K., Yamagata K., Watanabe Y. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever. Brain Res. 733:1996;263-272.
4. Cao C., Matsumura K., Watanabe Y. Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells. J. Neurosci. 19:1999;716-725.
5. Cao C., Matsumura K., Shirakawa N., Maeda M., Jikihara I., Kobayashi S., Watanabe Y. Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors. Eur. J. Neurosci. 13:2001;1781-1790.
6. 2 production in the rat adjuvant-arthritis model. J. Immunol. 170:2003;4738-4744.
7. Danton G.H., Dietrich W.D. Inflammatory mechanisms after ischemia and stroke. J. Neuropathol. Exp. Neurol. 62:2003;127-136.
8. 2 is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated prostaglandin E synthase. J. Immunol. 167:2001;3962-3971.
9. Ek M., Engblom D., Saha S., Blomqvist A., Jakobsson P.J., Ericsson-Dahlstrand A. Inflammatory response: pathways across the blood-brain barrier. Nature. 410:2001;430-432.
10. Faour W.H., He Y., He Q.W., de Ladurantaye M., Quintero M., Mancini A., Di Battista J.A. Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts. J. Biol. Chem. 276:2001;31720-31731.
11. FitzGerald G.A., Patrono C. Drug therapy: the coxibs, selective inhibitors of cyclooxygenase-2. New Engl. J. Med. 345:2001;433-442.
12. 2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. J. Neurosci. Res. 71:2003;844-852.
13. 2 synthase expression. J. Biol. Chem. 277:2002;16355-16364.
14. Holmin S., Mathiesen T. Intracerebral administration of interleukin-1β and induction of inflammation, apoptosis and vasogenic edema. J. Neurosurg. 92:2000;108-120.
15. Hurley S.D., Olschowka J.A., O'Banion M.K. Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J. Neurotrauma. 19:2002;1-15.
16. Jakobsson P.J., Thoren S., Morgenstern R., Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U. S. A. 96:1999;7220-7225.
17. 2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts. Arthritis Rheum. 48:2003;2819-2828.
18. Kyrkanides S., Moore A.H., Olschowka J.A., Williams J.P., Hansen J.T., O'Banion M.K. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Mol. Brain Res. 104:2002;159-169.
19. Lazarus M., Kubata B.K., Eguchi N., Fujitani Y., Urade Y., Hayaishi O. Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Arch. Biochem. Biophys. 397:2002;336-341.
20. Li S., Ballou L.R., Morham S.G., Blatteis C.M. Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta. Brain Res. 910:2001;163-173.
21. Maida M.E., O'Banion M.K. The cyclooxygenases in neuroinflammation and neurodegeneration: emerging perspectives. Bondy S.C., Campbell A. Inflammatory Events in Neurodegeneration. 2001;157-190 Prominent Press, Scottsdale, AZ.
22. Matsumura K., Cao C., Ozaki M., Morii H., Nakadate K., Watanabe Y. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J. Neurosci. 18:1998;6279-6289.
23. 2, cyclic AMP, and non-steroidal anti-inflammatory drugs. Eur. J. Neurosci. 9:1997;934-940.
24. Minghetti L., Walsh D.T., Levi G., Perry V.H. In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines. J. Neuropathol. Exp. Neurol. 58:1999;1184-1191.
25. Mitka M. Arthritis pain guidelines issued. JAMA. 287:2002;2067.
26. Moore A.H., O'Banion M.K. Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease. Adv. Drug Deliv. Rev. 54:2002;1627-1656.
27. Mrak R.E., Griffin W.S. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol. Aging. 22:2001;903-908.
28. 2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275:2000;32783-32792.
29. 2 synthase-2 via both cyclooxygenases-1 and -2. J. Biol. Chem. 278:2003;37937-37947.
30. O'Banion M.K., Winn V.D., Young D.A. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. U. S. A. 89:1992;4888-4892.
31. O'Banion M.K., Miller J.C., Chang J.W., Kaplan M.D., Coleman P.D. Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J. Neurochem. 66:1996;2532-2540.
32. O'Banion M.K., Kyrkanides S., Olschowka J.A. Selective inhibition of cyclooxgyenase-2 attenuates expression of inflammation-related genes in CNS injury. Adv. Exp. Med. Biol. 507:2002;155-160.
33. 2. Proc. Natl. Acad. Sci. U. S. A. 96:1999;4668-4773.
34. 2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. J. Exp. Med. 184:1996;883-890.
35. Stichtenoth D.O., Thoren S., Bian H., Peters-Golden M., Jakobsson P.J., Crofford L.J. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J. Immunol. 167:2001;469-474.
36. 2 biosynthesis. J. Biol. Chem. 275:2000;32775-32782.
37. Tegeder I., Pfeilschifter J., Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB. 15:2001;2057-2072.
38. Touzani O., Boutin H., LeFeuvre R., Parker L., Miller A., Luheshi G., Rothwell N. Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J. Neurosci. 22:2002;38-43.
39. Trebino C.E., Stock J.L., Gibbons C.P., Naiman B.M., Wachtmann T.S., Umland J.P.et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. U. S. A. 100:2003;9044-9049.
40. Uematsu S., Matsumoto M., Takeda K., Akira S. Lipopolysaccharide- dependent prostaglandin E(2) production is regulated by the glutathione- dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J. Immunol. 168:2002;5811-5816.
41. Wang C.X., Schuaib A. Involvement of inflammatory cytokines in central nervous system injury. Prog. Neurobiol. 67:2002;161-172.
42. Yamagata K., Matsumura K., Inoue W., Shiraki T., Suzuki K., Yasuda S., Sugiura H., Cao C., Watanabe Y., Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J. Neurosci. 21:2001;2669-2677.
43. 2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. J. Neurochem. 76:2001;855-864.