In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines

Journal of Neuropathology and Experimental Neurology

Volumn 58, Issue 11, 1999, Pages 1184-1191

  Minghetti, Luisa ^a   Walsh, Desmond T ^b   Levi, Giulio ^a   Perry, V Hugh ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c NONE

Author keywords

Inflammation; Interleukin 1 ; Lipopolysaccharide; Microglia; Neutrophils; Perivascular macrophages; Prostaglandins

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; CYTOKINE; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 13; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0032728897     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199911000-00008     Document Type: Article

References (39)

1. Smith, WL, Garavito RM, DeWitt DL. Prostaglandin Endoperoxide H Synthases (cyclooxygenase-1 and -2). J Biol Chem 1996;271: 33157-60
2. Breder CD, Dewitt D, Kraig R P. Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 1995;355:296-315
3. Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci USA 1996;93:2317-21
4. Marcheselli VL, Bazan NG. Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. J Biol Chem 1996;271:24794-99
5. Nogawa S, Zhang F, Ross ME, Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 1997;17:2746-55
6. 2. Proc Natl Acad Sci USA 1997;94:6500-505
7. Sanz O, Estrada A, Ferrer I, Planas AM. Differential cellular distribution and dynamics of Hsp70, cyclooxygenase-2 and c-fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience 1997;80:221-32
8. Cao C, Matsumura K, Yamagata K, Watanabe Y. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: A possible site of prostaglandin synthesis for fever. Brain Res 1996;733:263-72
9. Elmquist JK, Breder CD, Sherin JE et al. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J Comp Neurol 1997;381:119-29
10. Lacroix S, Rivest S. Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and (COX-2) in the rat brain. J Neurochem 1998;70:452-66
11. Matsumura K, Cao C, Ozaki M, Morii H, Nakatade K, Watanabe Y. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-inducedfever: Light and electron microscopic immunocytochemical studies. J Neurosci 1998;18:6279-89
12. Minghetti L, Hughes P, Perry VH. Restricted cyclooxygenase-2 expression in the central nervous system following acute and delayed-type hypersensitivity responses to bacillus Calmette-Guérin. Neuroscience 1999;92:1404-15
13. Matyszak MK. Inflammation in the CNS: Balance between immunological privilege and immune response. Prog Neurobiol 1998;56:19-35
14. Minghetti L, Levi G. Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide. Prog Neurobiol 1998;54,99-125
15. Andersson PB, Perry VH, Gordon S. The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues. Neuroscience 1992;48:169-86
16. Montero-Menei CN, Sindji L, Pouplard B-A, Jehan F, Denechaud L, Darcy F. Lipopolysaccharide intracerebral administration induces minimal inflammatory reaction in rat brain. Brain Res 1994;635: 101-11
17. Anthony DC, Bolton SJ, Fearn S, Perry VH. Age-related effects of interleukin-1β on polymorphonucleate neutrophil-dependent increases in blood-brain barrier permeability in rats. Brain 1997;120: 435-44
18. O'Banion MK, Miller JC, Chang JW, Kaplan MD, Coleman PD. Interleukin-1β induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J Neurochem 1996;66: 2532-40
19. 2a, production in human microglial cells but not in astrocytes. J Immunol 1996;157:2129-35
20. 2 production. Glia 1997;21:183-93
21. Matyszak MK, Perry VH. Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guérin. Neuroscience 1995;64:967-77
22. Mandai K, Matsumoto M, Kitagawa K, et al. Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia. Neuroscience 1997;77,849-61
23. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron 1993;11:371-86
24. Streit WJ, Kreutzerg GW. Lectin binding by resting and reactive microglia. J Neurocytol 1987;16:249-60
25. Minghetti L and Levi G. Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures. J Neurochem 1995;65:2690-98
26. Kitamura Y, Takadashi H, Matsuota Y, et al. In vivo induction of inducible nitric oxide synthase by microinjection with interferon-γ and lipopolysaccharide in rat hippocampus. Glia 1996;18:233-43
27. Minghetti L, Polazzi E, Nicolini A, Crèminon C, Levi G. Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J Neurochem 1996;66:1963-70
28. Tomlinson A, Appleton I, Moore A, et al. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br J Pharmacol 1994;113:693-98
29. Cassatella MA, Bazzoni F, Ceska M, Ferro I, Baggiolini M, Berton G. IL-8 production by human polymorphonuclear leucocytes. The chemoattractant formyl-methinyl-leucyl-phenilalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. J Immunol 1992;148:3216-20
30. Bussolati B, Mariano F, Montrucchio G, Piccoli G, Camussi G. Modulatory effectof interleukin-10 on the production of platelet-activating factor and superoxide anions by human leukocytes. Immunology 1997;90:440-47
31. Elmquist JK, Scammell TE, Saper CB. Mechanisms of CNS response to systemic immune challenge: The febrile response. Trends Neurosci 1997;20:565-70
32. Perry VH. Macrophages and the nervous system. Austin, Texas: R.G. Landes Company, CRC Press, 1994
33. 2 synthase (cyclooxygenase) in human monocytes. J Biol Chem 1990;265:16737-40
34. Masferrer JL, Zweifel BS, Seibert K, Needleman P J. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest 1990;86:1375-79
35. Schnell L, Fearn S, Schwab ME, Perry VH, Antony DC. Cytokine-induced acute inflammation in the brain and spinal cord. J Neuropathol Exp Neurol 1999;58:245-54
36. Phillips LM, Simon PJ, Lampson LA. Site-specific immune regulation in the brain: Differential modulation of major histocompatibility complex (MHC) proteins in brain stem vs.hippocampus. J Comp Neurol 1999;405:322-33
37. Phillips LM, Lampson LA. Site-specific control of T cell traffic in the brain: T cell entry to brain stem vs hippocampus after local injection of IFN-γ. J Neuroimmunol 1999;96:218-27
38. Hirst WD, Young KA, Newton R, Allport VC, Mariott DR, Wilkin GP. Expression of COX-2 by normal and reactive astrocytes in adult rat central nervous system. Mol Cell Neurosci 1999;13:57-68
39. 2) on microglial functions. Biochimie 1998;80:899-904