메뉴 건너뛰기




Volumn 117, Issue 25, 2004, Pages 6071-6084

ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner

Author keywords

Adhesion; ARAP3; Fibronectin; GTPase activating protein; Rho; Src family kinase

Indexed keywords

ARF PROTEIN; FIBRONECTIN; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ARAP3; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 12344338685     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01526     Document Type: Article
Times cited : (52)

References (50)
  • 2
    • 0035158377 scopus 로고    scopus 로고
    • RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity
    • Arthur, W. T. and Burridge, K. (2001). RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol. Biol. Cell 12 2711-2720.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2711-2720
    • Arthur, W.T.1    Burridge, K.2
  • 3
    • 0034659526 scopus 로고    scopus 로고
    • Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
    • Arthur, W. T., Petch, L. A. and Burridge, K. (2000). Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr. Biol. 10, 719-722.
    • (2000) Curr. Biol. , vol.10 , pp. 719-722
    • Arthur, W.T.1    Petch, L.A.2    Burridge, K.3
  • 4
    • 0033529562 scopus 로고    scopus 로고
    • A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins
    • Bagrodia, S., Bailey, D., Lenard, Z., Hart, M., Guan, J. L., Premont, R. T., Taylor, S. J. and Cerione, R. A. (1999). A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J. Biol. Chem. 274, 22393-22400.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22393-22400
    • Bagrodia, S.1    Bailey, D.2    Lenard, Z.3    Hart, M.4    Guan, J.L.5    Premont, R.T.6    Taylor, S.J.7    Cerione, R.A.8
  • 5
    • 3543072944 scopus 로고    scopus 로고
    • Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function
    • Berdeaux, R. L., Diaz, B., Kim, L. and Martin, G. S. (2004). Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J. Cell Biol. 166 317-323.
    • (2004) J. Cell Biol. , vol.166 , pp. 317-323
    • Berdeaux, R.L.1    Diaz, B.2    Kim, L.3    Martin, G.S.4
  • 6
    • 0037451803 scopus 로고    scopus 로고
    • GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila
    • Bernards, A. (2003). GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta Rev. Cancer 1603, 47-82.
    • (2003) Biochim. Biophys. Acta Rev. Cancer , vol.1603 , pp. 47-82
    • Bernards, A.1
  • 7
    • 0034458943 scopus 로고    scopus 로고
    • SU6656, a selective src family kinase inhibitor, used to probe growth factor signalling
    • Blake, R. A., Broome, M. A., Liu, X., Wu, J., Gishizky, M., Sun, L. and Courtneidge, S. A. (2000). SU6656, a selective src family kinase inhibitor, used to probe growth factor signalling. Mol. Cell. Biol. 20, 9018-9027.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9018-9027
    • Blake, R.A.1    Broome, M.A.2    Liu, X.3    Wu, J.4    Gishizky, M.5    Sun, L.6    Courtneidge, S.A.7
  • 8
    • 0035071323 scopus 로고    scopus 로고
    • p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation
    • Brouns, M. R., Matheson, S. F. and Settleman, J. (2001). p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat. Cell Biol. 3 361-367.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 361-367
    • Brouns, M.R.1    Matheson, S.F.2    Settleman, J.3
  • 9
    • 0031784899 scopus 로고    scopus 로고
    • ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src
    • Brown, M. T., Andrade, J., Radhakrishna, H., Donaldson, J. G., Cooper, J. A. and Randazzo, P. A. (1998). ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol. Cell. Biol. 18, 7038-7051.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7038-7051
    • Brown, M.T.1    Andrade, J.2    Radhakrishna, H.3    Donaldson, J.G.4    Cooper, J.A.5    Randazzo, P.A.6
  • 11
    • 0032572557 scopus 로고    scopus 로고
    • Integrin-mediated signals regulated by members of the Rho family of GTPases
    • Clark, E. A., King, W. G., Brugge, J. S., Symons, M. and Hynes, R. O. (1998). Integrin-mediated signals regulated by members of the Rho family of GTPases. J. Cell Biol. 142, 573-586.
    • (1998) J. Cell Biol. , vol.142 , pp. 573-586
    • Clark, E.A.1    King, W.G.2    Brugge, J.S.3    Symons, M.4    Hynes, R.O.5
  • 12
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S. and Hall, A. (2002). Rho GTPases in cell biology. Nature 420, 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 14
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 15
    • 1942509343 scopus 로고    scopus 로고
    • Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase
    • Hernandez, S. E., Settleman, J. and Koleske, A. J. (2004). Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase. Curr. Biol. 14 691-696.
    • (2004) Curr. Biol. , vol.14 , pp. 691-696
    • Hernandez, S.E.1    Settleman, J.2    Koleske, A.J.3
  • 16
    • 0029955660 scopus 로고    scopus 로고
    • An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase
    • Hildebrand, J. D., Taylor, J. M. and Parsons, J. T. (1996). An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell. Biol. 16 3169-3178.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3169-3178
    • Hildebrand, J.D.1    Taylor, J.M.2    Parsons, J.T.3
  • 17
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signalling machines
    • Hynes, R. O. (2002). Integrins: bidirectional, allosteric signalling machines. Cell 110, 673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 18
    • 0033950864 scopus 로고    scopus 로고
    • Turning on ARF: The Sec7 family of guanine-nucleotide-exchange factors
    • Jackson, C. L. and Casanova, J. E. (2000). Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors. Trends Cell Biol. 10, 60-67.
    • (2000) Trends Cell Biol. , vol.10 , pp. 60-67
    • Jackson, C.L.1    Casanova, J.E.2
  • 20
    • 0034306280 scopus 로고    scopus 로고
    • Cytohesins and centaurins: Mediators of PI 3-kinase-regulated Arf signalling
    • Jackson, T. R., Kearns, B. G. and Theibert, A. B. (2000b). Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signalling. Trends Biochem. Sci. 25, 489-495.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 489-495
    • Jackson, T.R.1    Kearns, B.G.2    Theibert, A.B.3
  • 21
    • 0029034939 scopus 로고
    • C-Src enhances the spreading of Src-/- fibroblasts on fibronectin by a kinase-independent mechanism
    • Kaplan, K. B., Swedlow, J. R., Morgan, D. O. and Varmus, H. E. (1995). C-Src enhances the spreading of Src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 9, 1505-1517.
    • (1995) Genes Dev. , vol.9 , pp. 1505-1517
    • Kaplan, K.B.1    Swedlow, J.R.2    Morgan, D.O.3    Varmus, H.E.4
  • 22
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H. and Downward, J. (1997). Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16, 2783-2793.
    • (1997) EMBO J. , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 23
    • 0032981182 scopus 로고    scopus 로고
    • DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines
    • King, F. J., Hu, E. D., Harris, D. F., Sarraf, P., Spiegelman, B. M. and Roberts, T. M. (1999). DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Mol. Cell. Biol 19, 2330-2337.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2330-2337
    • King, F.J.1    Hu, E.D.2    Harris, D.F.3    Sarraf, P.4    Spiegelman, B.M.5    Roberts, T.M.6
  • 24
    • 0033522510 scopus 로고    scopus 로고
    • Src family kinases are required for integrin but not PDGFR signal transduction
    • Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. and Soriano, P. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18, 2459-2471.
    • (1999) EMBO J. , vol.18 , pp. 2459-2471
    • Klinghoffer, R.A.1    Sachsenmaier, C.2    Cooper, J.A.3    Soriano, P.4
  • 25
    • 18244392475 scopus 로고    scopus 로고
    • Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
    • Krugmann, S., Anderson, K. E., Ridley, S. H., Risso, N., McGregor, A., Coadwell, J., Davidson, K., Eguinoa, A., Ellson, C. D., Lipp, P. et al. (2002). Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell 9, 95-108.
    • (2002) Mol. Cell , vol.9 , pp. 95-108
    • Krugmann, S.1    Anderson, K.E.2    Ridley, S.H.3    Risso, N.4    McGregor, A.5    Coadwell, J.6    Davidson, K.7    Eguinoa, A.8    Ellson, C.D.9    Lipp, P.10
  • 26
    • 0042031108 scopus 로고    scopus 로고
    • The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1
    • Kruljac-Letunic, A., Moelleken, J., Kallin, A., Wieland, F. and Blaukat, A. (2003). The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J. Biol. Chem. 278, 29560-29570.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29560-29570
    • Kruljac-Letunic, A.1    Moelleken, J.2    Kallin, A.3    Wieland, F.4    Blaukat, A.5
  • 27
    • 0032480013 scopus 로고    scopus 로고
    • A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate
    • Lock, P., Abram, C. L., Gibson, T. and Courtneidge, S. A. (1998). A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate. EMBO J. 17, 4346-4357.
    • (1998) EMBO J. , vol.17 , pp. 4346-4357
    • Lock, P.1    Abram, C.L.2    Gibson, T.3    Courtneidge, S.A.4
  • 28
    • 0033529502 scopus 로고    scopus 로고
    • Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck
    • Lock, P., Casagranda, F. and Dunn, A. R. (1999). Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. J. Biol. Chem. 274 22775-22784.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22775-22784
    • Lock, P.1    Casagranda, F.2    Dunn, A.R.3
  • 29
    • 1842843307 scopus 로고    scopus 로고
    • Interfering with Ras signalling using membrane-permeable peptides or drugs
    • Maruta, H., He, H. and Nheu, T. (2002). Interfering with Ras signalling using membrane-permeable peptides or drugs. Methods Mol. Biol. 189, 75-85.
    • (2002) Methods Mol. Biol. , vol.189 , pp. 75-85
    • Maruta, H.1    He, H.2    Nheu, T.3
  • 32
    • 0031594710 scopus 로고    scopus 로고
    • Activation of beta 1 integrin signalling stimulates tyrosine phosphorylation of p190(RhoGAP) and membrane-protrusive activities at invadopodia
    • Nakahara, H., Mueller, S. C., Nomizu, M., Yamada, Y., Yeh, Y. Y. and Chen, W. T. (1998). Activation of beta 1 integrin signalling stimulates tyrosine phosphorylation of p190(RhoGAP) and membrane-protrusive activities at invadopodia. J. Biol. Chem. 273, 9-12.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9-12
    • Nakahara, H.1    Mueller, S.C.2    Nomizu, M.3    Yamada, Y.4    Yeh, Y.Y.5    Chen, W.T.6
  • 33
    • 0037073704 scopus 로고    scopus 로고
    • AGAP1: An endosome-associated, phosphoinositide-dependent Arf GAP that affects the actin cytoskeleton
    • Nie, Z., Stanley, K. T., Stauffer, S., Jacques, K. M., Hirsch, D. S., Takei, J. and Randazzo, P. A. (2002). AGAP1: an endosome-associated, phosphoinositide-dependent Arf GAP that affects the actin cytoskeleton. J. Biol. Chem. 277, 48965-48975.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48965-48975
    • Nie, Z.1    Stanley, K.T.2    Stauffer, S.3    Jacques, K.M.4    Hirsch, D.S.5    Takei, J.6    Randazzo, P.A.7
  • 34
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • Nobes, C. D. and Hall, A. (1999). Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235-1244.
    • (1999) J. Cell Biol. , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 35
    • 0034693854 scopus 로고    scopus 로고
    • Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
    • Parsons, J. T., Martin, K. H., Slack, J. K., Taylor, J. M. and Weed, S. A. (2000). Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19, 5606-5613.
    • (2000) Oncogene , vol.19 , pp. 5606-5613
    • Parsons, J.T.1    Martin, K.H.2    Slack, J.K.3    Taylor, J.M.4    Weed, S.A.5
  • 36
    • 0031844821 scopus 로고    scopus 로고
    • Activation of Rac and Cdc42 by integrins mediates cell spreading
    • Price, L. S., Leng, J., Schwartz, M. A. and Bokoch, G. M. (1998). Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol. Biol. Cell 9, 1863-1871.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 1863-1871
    • Price, L.S.1    Leng, J.2    Schwartz, M.A.3    Bokoch, G.M.4
  • 38
    • 0034700364 scopus 로고    scopus 로고
    • Molecular aspects of the cellular activities of ADP-ribosylation factors
    • Randazzo, P. A., Nie, Z., Miura, K. and Hsu, V. W. (2000b). Molecular aspects of the cellular activities of ADP-ribosylation factors. Sci. STKE. 2000, RE1.
    • (2000) Sci. STKE. , vol.2000
    • Randazzo, P.A.1    Nie, Z.2    Miura, K.3    Hsu, V.W.4
  • 39
    • 0033081753 scopus 로고    scopus 로고
    • Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    • Ren, X. D., Kiosses, W. B. and Schwartz, M. A. (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585.
    • (1999) EMBO J. , vol.18 , pp. 578-585
    • Ren, X.D.1    Kiosses, W.B.2    Schwartz, M.A.3
  • 41
    • 0033214460 scopus 로고    scopus 로고
    • Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells
    • Salazar, E. P. and Rozengurt, E. (1999). Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells. J. Biol. Chem. 274, 28371-28378.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28371-28378
    • Salazar, E.P.1    Rozengurt, E.2
  • 42
    • 0037076462 scopus 로고    scopus 로고
    • GTPase signalling: Bridging the GAP between ARF and Rho
    • Santy, L. C. and Casanova, J. E. (2002). GTPase signalling: bridging the GAP between ARF and Rho. Curr. Biol. 12 R360-R362.
    • (2002) Curr. Biol. , vol.12
    • Santy, L.C.1    Casanova, J.E.2
  • 43
    • 0028122650 scopus 로고
    • Focal adhesion kinase and associated proteins
    • Schaller, M. D. and Parsons, J. T. (1994). Focal adhesion kinase and associated proteins. Curr. Opin. Cell Biol. 6, 705-710.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 705-710
    • Schaller, M.D.1    Parsons, J.T.2
  • 44
    • 0032127912 scopus 로고    scopus 로고
    • GTPase-activating proteins: Helping hands to complement an active site
    • Scheffzek, K., Ahmadian, M. R. and Wittinghofer, A. (1998). GTPase-activating proteins: helping hands to complement an active site. Trends Biochem. Sci. 23, 257-262.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 257-262
    • Scheffzek, K.1    Ahmadian, M.R.2    Wittinghofer, A.3
  • 45
    • 0030926774 scopus 로고    scopus 로고
    • Focal adhesion kinase overexpression enhances Ras-dependent integrin signalling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
    • Schlaepfer, D. D. and Hunter, T. (1997). Focal adhesion kinase overexpression enhances Ras-dependent integrin signalling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J. Biol. Chem. 272, 13189-13195.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13189-13195
    • Schlaepfer, D.D.1    Hunter, T.2
  • 47
    • 0035960717 scopus 로고    scopus 로고
    • Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity
    • Timpson, P., Jones, G. E., Frame, M. C. and Brunton, V. G. (2001). Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity. Curr. Biol. 11, 1836-1846.
    • (2001) Curr. Biol. , vol.11 , pp. 1836-1846
    • Timpson, P.1    Jones, G.E.2    Frame, M.C.3    Brunton, V.G.4
  • 48
    • 0035479908 scopus 로고    scopus 로고
    • Paxillin-ARF GAP signalling and the cytoskeleton
    • Turner, C. E., West, K. A. and Brown, M. C. (2001). Paxillin-ARF GAP signalling and the cytoskeleton. Curr. Opin. Cell Biol. 13, 593-599.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 593-599
    • Turner, C.E.1    West, K.A.2    Brown, M.C.3
  • 49
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signalling networks
    • van Aelst, L. and D'Souza-Schorey, C. (1997). Rho GTPases and signalling networks. Genes Dev. 11, 2295-2322.
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • van Aelst, L.1    D'Souza-Schorey, C.2
  • 50
    • 0028875162 scopus 로고
    • Recognition and specificity in protein tyrosine kinase-mediated signalling
    • Zhou, S. and Cantley, L. C. (1995). Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends Biochem. Sci. 20, 470-475.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 470-475
    • Zhou, S.1    Cantley, L.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.