DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines

Molecular and Cellular Biology

Volumn 19, Issue 3, 1999, Pages 2330-2337

  King, Frederick J ^a   Hu, Erding ^a,b   Harris, David F ^a   Sarraf, Pasha ^a   Spiegelman, Bruce M ^a   Roberts, Thomas M ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PROTEIN DEF 1; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; FIBROBLAST; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION;

ANIMALIA; BOVINAE;

EID: 0032981182     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.3.2330     Document Type: Article

References (68)

1. Alexandropoulos, K., G. Cheng, and D. Baltimore. 1995. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl. Acad. Sci. USA 92:3110-3114.
2. Bar-Sagi, D., D. Rotin, A. Batzer, V. Mandiyan, and J. Schlessinger. 1993. SH3 domains direct cellular localization of signaling molecules. Cell 74:83-91.
3. Benito, M., A. Porras, A. R. Nebreda, and E. Santos. 1991. Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes. Science 253:565-568.
4. Bjorbaek, C., S. Uotan, B. da Silva, and J. S. Flier. 1997. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272:32686-32695.
5. Brown, M. T., J. Andrade, H. Radhakrishna, J. G. Donaldson, J. A. Cooper, and P. A. Randazzo. 1998. ASAP1, a phospholipid-dependent Arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol. Cell. Biol. 18:7038-7051.
6. Brun, R. P., P. Tontonoz, B. M. Forman, R. Ellis, J. Chen, R. M. Evans, and B. M. Spiegelman. 1996. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 10:974-984.
7. Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538-1552.
8. Chan, J., I. Aksov, and C. Furman. Personal communication.
9. Chardin, P., J. H. Camonis, N. W. Gale, L. van Aelst, J. Schlessinger, M. H. Wigler, and D. Bar-Sagi. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338-1343.
10. Cohen, G. B., R. Ren, and D. Baltimore. 1995. Modular binding domains in signal transduction proteins. Cell 80:237-248.
11. Cornelius, P., O. A. MacDougald, and M. D. Lane. 1994. Regulation of adipocyte development. Annu. Rev. Nutr. 14:99-129.
12. Courtneidge, S. A. 1994. Protein tyrosine kinases, with emphasis on the Src family. Semin. Cancer Biol. 5:239-246.
13. Dai, Z., and A. M. Pendergast. 1995. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev. 9:2569-2582.
14. Darnell, J. E., Jr. 1996. Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc. Natl. Acad. Sci. USA 93:6221-6224.
15. Downing, A. K., P. C. Driscoll, I. Gout, K. Salim, M. J. Zvelebil, and M. D. Waterfield. 1994. Three-dimensional solution structure of the pleckstrin homology domain from dynamin. Curr. Biol. 4:884-891.
16. Feng, S., C. Kasahara, R. J. Rickles, and S. L. Schreiber. 1995. Specific interactions outside the proline-rich core of two classes of Src homology 3 ligand. Proc. Natl. Acad. Sci. USA 92:12408-12415.
17. Fernandez, J., L. Andrews, and S. M. Mische. 1994. An improved procedure for enzymatic digestion of polyvinylidene difluoride-bound proteins for internal sequence analysis. Anal. Biochem. 218:112-117.
18. Forman, B. M., P. Tontonoz, J. Chen, R. P. Brun, B. M. Spiegelman, and R. M. Evans. 1995. 15-Deoxy-Δ 12,14-prostaglandin J2 is a ligand for the adiptocyte determination factor PPARγ. Cell 83:803-812.
19. Fukuda, M., J. Aruga, M. Niinobe, S. Aimoto, and K. Mikoshiba. 1994. Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. J. Biol. Chem. 269:29206-29211.
20. Fumagalli, S., N. F. Totty, J. J. Hsuan, and S. A. Courtneidge. 1994. A target for Src in mitosis. Nature 368:871-874.
21. Furman, C. Unpublished data.
22. Ghilardi, N., and R. C. Skoda. 1997. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol. Endocrinol. 11:393-399.
23. Ghilardi, N., S. Ziegler, A. Wiestner, R. Stoffel, M. H. Heim, and R. C. Skoda. 1996. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA 39:6231-6235.
24. Gout, I., R. Dhand, I. D. Hiles, M. J. Fry, G. Panayotou, P. Das, O. Truong, N. F. Totty, J. Hsuan, G. W. Booker, et al. 1993. The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell 75:25-36.
25. Hasegawa, H., E. Kiyokawa, S. Tanaka, K. Nagashima, N. Gotoh, M. Shibuya, T. Kurata, and M. Matsuda. 1996. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell. Biol. 16:1770-1776.
26. Hwang, C. S., T. M. Loftus, S. Mandrup, and M. D. Lane. 1997. Adipocyte differentiation and leptin expression. Annu. Rev. Cell Dev. Biol. 13:231-259.
27. Kitamura, T., Y. Kitamura, K. Yonezawa, N. F. Totty, I. Gout, K. Hara, M. D. Waterfield, M. Sakaue, W. Ogawa, and M. Kasuga. 1996. Molecular cloning of p125Napl, a protein that associates with an SH3 domain of Nck. Biochem. Biophys. Res. Commun. 219:509-514.
28. Kletzien, R. F., S. D. Clarke, and R. G. Ulrich. 1992. Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol. Pharmacol. 41:393-398.
29. Kliewer, S. A., B. M. Forman, B. Blumberg, E. S. Ong, U. Borgmeyer, D. J. Mangelsdorf, K. Umesono, and R. M. Evans. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91:7355-7359.
30. Laborda, J. 1991. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res. 19:3998.
31. Lane, W. S., A. Galat, M. W. Harding, and S. L. Schreiber. 1991. Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. J. Protein Chem. 10:151-160.
32. Lee, C. C., and C. T. Caskey. 1990. cDNA cloning using degenerate primers, p. 46-53. In M. A. Innis, D. H. Gelfad, J. J. Sninsky, and T. J. White (ed.), PCR protocols: a guide to methods and applications. Academic Press, San Diego, Calif.
33. Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 270:12953-12956.
34. Leibel, R. L., W. K. Chung, and S. C. Chua, Jr. 1997. The molecular genetics of rodent single gene obesities. J. Biol. Chem. 272:31937-31940.
35. Lim, W. A., F. M. Richards, and R. O. Fox. 1994. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature 372:375-379.
36. MacDougald, O. A., and M. D. Lane. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64: 345-373.
37. Mandrup, S., and M. D. Lane. Regulating adipogenesis. J. Biol. Chem. 272:5367-5370.
38. Marth, J. D., D. B. Lewis, M. P. Cooke, E. D. Mellins, M. E. Gearn, L. E. Samelson, C. B. Wilson, A. B. Miller, and R. M. Perlmutter. 1989. Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck). J. Immunol. 142:2430-2437.
39. McKinney, B., and M. Riley. 1967. An orecin-oil red O stain for concomitant demonstration of elastic tissue and lipid. Stain Technol. 42:245-258.
40. McNamee, H., and I. Aksoy. Personal communication.
41. Michaely, P., and V. Bennett. 1993. The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. J. Biol. Chem. 268:22703-22709.
42. Miller, R. J., and G. I. Bell. 1996. JAK/STAT eats the fat. Trends Neurosci. 19:159-161.
43. Pawson, T. 1988. Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction. Oncogene 491-495.
44. Pawson, T. 1995. Protein modules and signalling networks. Nature 373:573-580.
45. Pawson, T., and J. D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science 278:2075-2080.
46. Porras, A., K. Muszynski, U. R. Rapp, and E. Santos. 1994. Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells. J. Biol. Chem. 269:12741-12748.
47. Richard, S., D. Yu, K. J. Blumer, D. Hausladen, M. W. Olszowy, P. A. Connelly, and A. S. Shaw. 1995. Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase Cγ-1. Mol. Cell. Biol. 15:186-197.
48. Rickles, R. J., M. C. Botfield, X. M. Zhou, P. A. Henry, J. S. Brugge, and M. J. Zoller. 1995. Phage display selection of ligand residues important for Src homology 3 domain binding specificity. Proc. Natl. Acad. Sci. USA 92:10909-10913.
49. Sandouk, T., D. Reda, and C. Hofmann. 1993. Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells. Am. J. Physiol. 264:C1600-C1608.
50. Scaife, R., and R. L. Margolis. 1990. Biochemical and immunochemical analysis of rat brain dynamin interaction with microtubules and organelles in vivo and in vitro. J. Cell Biol. 111:3023-3033.
51. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621-651.
52. Sparks, A. B., N. B. Adey, L. A. Quilliam, J. M. Thorn, and B. K. Kay. 1995. Screening phage-displayed random peptide libraries for SH3 ligands. Methods Enzymol. 255:498-509.
53. Spiegelman, B. M., L. Choy, G. S. Hotamisligil, R. A. Graves, and P. Tontonoz. 1993. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J. Biol. Chem. 268:6823-6826.
54. Spiegelman, B. M., and J. S. Flier. 1996. Adipogenesis and obesity: rounding out the big picture. Cell 87:377-389.
55. Sudol, M. 1994. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the yes proto-oncogene product. Oncogene 9:2145-2152.
56. Tanabe, K., S. Okuya, Y. Tanizawa, A. Matsutani, and Y. Oka. 1997. Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 241: 765-768.
57. Tanaka, K., S. Imajoh-Ohmi, T. Sawada, R. Shirai, Y. Hashimoto, S. Iwasaki, K. Kaibuchi, Y. Kanaho, T. Shirai, Y. Terada, K. Kimura, S. Nagata, and Y. Fukui. 1997. A target of phosphatidylinositol 3,4,5-triphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains. Eur. J. Biochem. 245:512-519.
58. Tartaglia, L. A. 1997. The leptin receptor. J. Biol. Chem. 272:32686-32695.
59. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, J. Deeds, et al. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
60. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman, 1994. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234.
61. Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPAR-γ2. a lipid-activated transcription factor. Cell 79:1147-1156.
62. Trainor, C. D., T. Evans, G. Felsenfeld, and M. S. Boguski. 1990. Structure and evolution of a human erythroid transcription factor. Nature 343:92-96.
63. Weng, Z., R. J. Rickles, S. Feng, S. Richard, A. S. Shaw, S. L. Schreiber, and J. S. Brugge. 1995. Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions. Mol. Cell. Biol. 15: 5627-5634.
64. Williamson, M. P. 1994. The structure and function of proline-rich regions in proteins. Biochem. J. 297:249-260.
65. Wu, Z., N. L. R. Bucher, and S. R. Farmer. 1996. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol. Cell. Biol. 16:4128-4136.
66. Yamabhai, M., and B. K. Kay. 1997. Examining the specificity of Src homology 3 domain - ligand interactions with alkaline phosphatase fusion proteins. Anal. Biochem. 247:143-151.
67. Yeh, W. C., Z. Cao, M. Classon, and S. L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168-181.
68. Yu, H., J. K. Chen, S. Feng, D. C. Dalgarno, A. W. Brauer, and S. L. Schreiber. 1994. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76:933-945.