An improved synthesis of piperazino-piperidine based CCR5 antagonists with flexible variation on pharmacophore sites

Tetrahedron

Volumn 61, Issue 5, 2005, Pages 1281-1288

  Jiang, Xiao Hua ^a   Song, Yan Li ^a   Feng, Dong Zhi ^a   Long, Ya Qiu ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

4 Substituent 4 aminopiperidine; CCR5 antagonist; Chiral pool; Piperazino piperidine nucleus; Reductive amination

Indexed keywords

ALUMINUM DERIVATIVE; AMINO ACID DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CYANIDE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE;

AMINATION; ARTICLE; CHIRALITY; GRIGNARD REACTION; PHARMACOPHORE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STEREOCHEMISTRY; STRECKER SYNTHESIS; SUBSTITUTION REACTION; SYNTHESIS;

EID: 12344332654     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.11.057     Document Type: Article

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