Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 14, 2004, Pages 3675-3678

  Jiang, Xiao Hua ^a   Song, Yan Li ^a   Long, Ya Qiu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

4 Substituted 4 aminopiperidine; Building block; Convergent synthesis; Curtius rearrangement; HIV 1 entry inhibitor; Piperazine based CCR5 antagonist

Indexed keywords

AMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5; CYANIDE; ISONIPECOTIC ACID; PIPERIDINE; PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR; REAGENT; SCH 350634; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CURTIUS REARRANGEMENT; DRUG SYNTHESIS; METHODOLOGY; SUBSTITUTION REACTION;

ALKYLATION; ANTI-HIV AGENTS; CELL LINE; HIV-1; ISONIPECOTIC ACIDS; ORGANOMETALLIC COMPOUNDS; PIPERIDINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 2942685109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.014     Document Type: Article

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