Sulfonamide drugs binding to the colchicine site of tubulin: Thermodynamic analysis of the drug-tubulin interactions by isothermal titration calorimetry

Journal of Medicinal Chemistry

Volumn 48, Issue 2, 2005, Pages 547-555

  Banerjee, Mithu ^a   Poddar, Asim ^a   Mitra, Gopa ^a   Surolia, Avadhesha ^b   Owa, Takashi ^c   Bhattacharyya, Bhabatarak ^a  

^a BOSE INSTITUTE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

^c EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; GUANOSINE TRIPHOSPHATASE; N (5 CHLORO 7 INDOYL) 4 METHOXYBENZENESULFONAMIDE; SULFONAMIDE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; MICROTUBULE ASSEMBLY; PROTEIN CONFORMATION; PROTEIN INTERACTION; THERMODYNAMICS;

ANTINEOPLASTIC AGENTS; BINDING SITES; CALORIMETRY; COLCHICINE; INDOLES; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THERMODYNAMICS; TUBULIN;

EID: 12344326693     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0494974     Document Type: Article

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