Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia

Psychiatry Research

Volumn 81, Issue 2, 1998, Pages 117-123

  Ohara, Koichi ^a   Nagai, Miho ^a   Tani, Kunihiko ^a   Nakamura, Yuhei ^a   Ino, Atsushi ^a   Ohara, Kenshiro ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

141C Ins Del; D2 receptor; Gene; Polymorphism; Promoter; Schizophrenia

Indexed keywords

DNA; DOPAMINE 2 RECEPTOR; LUCIFERASE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; SCHIZOPHRENIA;

ADULT; ALLELES; BRAIN; CHROMOSOME DELETION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; POLYMORPHISM, GENETIC; PROGNOSIS; PROMOTER REGIONS (GENETICS); RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0032538921     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(98)00092-4     Document Type: Article

References (40)

1. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. American Psychiatric Press, Washington, D.C.
2. 2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat. Molecular Brain Research. 11:1991;161-166.
3. 2 receptor gene is associated with schizophrenia. Human Molecular Genetics. 6:1997;577-582.
4. Burt D.R., Creese I., Snyder S.H. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 196:1977;326-328.
5. 2 receptors in schizophrenia studied in vivo. Lancet. 2:1986;224-225.
6. Crow T.J., Johnstone E.C., Longden A.J., Owen F. Dopaminergic mechanisms in schizophrenia: the antipsychotic effect and the disease process. Life Sciences. 23:1978;562-567.
7. Crow T.J. Molecular pathology of schizophrenia: more than one disease process? British Medical Journal. 280:1980;66-68.
8. Crow T.J. Positive and negative schizophrenic symptoms and the role of dopamine. British Journal of Psychiatry. 137:1980;383-386.
9. Crow T.J. Positive and negative schizophrenic symptoms and the role of dopamine. British Journal of Psychiatry. 139:1981;251-254.
10. Endicott, J., Spitzer, R.L., 1978. A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry 35, 837-844 (translated into Japanese by Hosaki, H., Kitamura, T., Kato, M., Sakio, E., Shima, S., Takahashi, R. Seiwa Shoten Publishers, Tokyo, 1983).
11. 2 receptor increase in PET study of schizophrenia. (Letter) Archives of General Psychiatry. 44:1987;671-672.
12. 2 dopamine receptors in antipsychotic-naive schizophrenic patients. Archives of General Psychiatry. 47:1990;213-219.
13. 2 dopamine receptor protein independently of RNA levels in mice. Life Sciences. 48:1991;1015-1022.
14. 2 dopamine receptor characteristics in antipsychotic-naive schizophrenic patients studied with positron emission tomography. Archives of General Psychiatry. 51:1994;116-123.
15. 2A receptor exons and the adjoining intron regions in schizophrenia. Neuropsychopharmacology 14, 339-347; correction, 1996, 15, 323.
16. 2A receptor exons and the adjoining intron regions in schizophrenia. Neuropsychopharmacology 14, 339-347; correction, 1996, 15, 323.
17. Kay, S.R., Opler, L.A., Fiszbein, A., 1991. Positive and Negative Syndrome Scale (PANSS) Rating Manual. Multi-Health Systems Inc., Toronto (translated into Japanese by Yamada, H., Masui, K., Kikumoto, K. Seiwa Shoten Publishers, Tokyo, 1991).
18. 3H-spiperone binding sites in postmortem brains from schizophrenic patients: relationship to antipsychotic drug treatment, abnormal movements, and positive symptoms. Journal of Neural Transmission. 75:1989;1-10.
19. 3H-apomorphine in schizophrenic brains. Nature. 274:1978;897-900.
20. Lee T., Seeman P. Elevation of brain antipsychotic/dopamine receptors in schizophrenia. American Journal of Psychiatry. 137:1980;191-197.
21. Mackay A.V.P., Bird E.D., Spokes E.G., Rossor M., Iversen L.L., Creese I., Snyder S.H. Dopamine receptors and schizophrenia: drug effect or illness? Lancet. 2:1980;915-916.
22. Mackay A.V.P., Iversen L.L., Rossor M., Spokes E., Bird E., Arregui A., Creese I., Snyder S.H. Increased dopamine and dopamine receptors in schizophrenia. Archives of General Psychiatry. 39:1982;991-997.
23. 76Br]-bromospiperone in untreated schizophrenic patients. American Journal of Psychiatry. 147:1990;44-50.
24. 76Br-bromolisuride. British Journal of Psychiatry. 158:1991;346-350.
25. 2 receptors and negative symptoms of schizophrenia. British Journal of Psychiatry. 164:1994;27-34.
26. 2 receptor isoforms in various cerebral tissues. Journal of Neurochemistry. 58:1992;673-679.
27. 2-receptor mRNA level in rat striatum after chronic haloperidol treatment. Neuroscience Research. 12:1991;440-445.
28. 2 receptors in chronic schizophrenics. Biological Psychiatry. 21:1986;1407-1414.
29. 11C]N-methylspiperone. Psychiatry Research. 61:1995;67-83.
30. 4) receptors in schizophrenia. Biological Psychiatry. 40:1996;1209-1217.
31. Ohara K., Ino A., Ishigaki T., Tani K., Tsukamoto T., Nakamura Y., Ohara K. Analysis of the 5′-flanking promoter region of the 5-HT2A receptor gene in schizophrenia. Neuropsychopharmacology. 17:1997;274-278.
32. Owen F., Cross A.J., Crow T.J., Longden A., Poulter M., Riley G.J. Increased dopamine-receptor sensitivity in schizophrenia. Lancet. 2:1978;223-226.
33. 2 receptor isoforms in brain tissue from controls and schizophrenics. Molecular Brain Research. 25:1994;173-175.
34. 2 dopamine receptors in schizophrenia. Alzheimer's, Parkinson's and Huntington's diseases. Neuropsychopharmacology. 1:1987;5-15.
35. 2 receptor mRNAs in rat brain. Journal of Molecular Neuroscience. 2:1990;155-161.
36. Toru, M., 1984. Seishinbunretsubyo no yakuri in Japanese (Pharmacology in Schizophrenia). Chu-Gai Igakusha Co, Tokyo.
37. Van Tol H.H.M., Riva M., Civelli O., Creese I. Lack of effect of chronic dopamine receptor blockade on dopamine receptor mRNA level. Neuroscience Letters. 111:1990;303-308.
38. Wang L., Hirayasu K., Ishizawa M., Kobayashi Y. Purification of genomic DNA from human whole blood by isopropanol-fractionation with concentrated NaI and SDS. Nucleic Acids Research. 22:1994;1774-1775.
39. 2 dopamine receptors in drug-naive schizophrenics. Science 234, 1558-1563; correction, 1987, 235, 623.
40. 2 dopamine receptors in drug-naive schizophrenics. Science 234, 1558-1563; correction, 1987, 235, 623.