No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar or unipolar affective disorders

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 81, Issue 5, 1998, Pages 385-387

  Furlong, Robert A ^a,b   Coleman, Tabytha A ^a   Ho, Luk ^c   Rubinsztein, Judy S ^c   Walsh, Cathy ^c   Paykel, Eugene S ^c   Rubinsztein, David C ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Bipolar affective disorder; Dopamine D2 receptor promoter polymorphism; Unipolar affective disorder

Indexed keywords

DOPAMINE 2 RECEPTOR;

ARTICLE; DOPAMINERGIC SYSTEM; FEMALE; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; PROMOTER REGION;

BIPOLAR DISORDER; DEPRESSIVE DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; LINKAGE (GENETICS); MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RECEPTORS, DOPAMINE D2;

EID: 0031713342     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19980907)81:5<385::AID-AJMG6>3.0.CO;2-S     Document Type: Article

References (17)

1. Arinami T, Itokawa M, Aoki J, Shibuya H, Ookubo Y, Iwawaki A, Ota K, Shimizu H, Hamaguchi H, Toru M (1996): Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders. Am J Med Genet 67:133-138.
2. Arinami T, Gao M, Hamaguchi H, Toru M (1997): A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6:577-582.
3. Baxter LR, Phelps ME, Mazziotta JC, Schwarz JM, Gerner RH, Sellin CE, Sumida RM (1985): Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry 42:441-447.
4. Breslow NE, Day NE (1980): "Statistical Methods in Core Research, Volume I: The Design and Analysis of Case-Control Studies." Lyon: IARC Scientific Publications, no. 32.
5. 18F]2-deoxyglucose in affective illness. J Affective Disord 10:137-152.
6. Craddock N, Roberts Q, Williams N, McGuffin P, Owen MJ (1995): Association study of bipolar disorder using a functional polymorphism (Ser311-Cys) in the dopamine D2 recptor gene. Psychiatr Genet 5:63-65.
7. Endicott J, Spitzer RL (1978): A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatry 35:837-862.
8. Gandelman KY, Harmon S, Todd RD, O'Malley KL (1991): Analysis of the structure and expression of the human dopamine D2A receptor gene. J Neurochem 56:1024-1029.
9. Gershon ES (1990): Genetics. In Goodwin FK, Jamison KR (eds): "Manic-Depressive Illness." Oxford University Press, pp 373-401.
10. 2 dopamine receptor. Proc Natl Acad Sci USA 86:9762-9766.
11. Manki H, Kanba S, Muramatsu T, Higuchi S, Suzuki E, Matsushita S, Ono Y, Chiba H, Shintani F, Nakamura M, Yagi G, Asai M (1996): Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. J Affective Disord 40:7-13.
12. McGuffin P, Katz R (1989): The genetics of depression and manic-depressive disorder. Br J Psychiatry 155:294-304.
13. Nothen MM, Erdmann J, Korner J (1992): Lack of association between dopamine Dl and D2 receptor genes and bipolar affective disorder. Am J Psychiatry 149:199-201.
14. Perez de Castro JP, Santos J, Torres P, Visedo G, Saiz-Ruiz J, Llinares C, Fernandez-Piqueras (1995): A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample. J Med Genet 32:131-134.
15. Souery D, Lipp O, Mahieu B, Mendelbaum K, De Martelaer V, Van Broeckhoven C, Mendlewicz J (1996): Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. Am J Med Genet 67:551-555.
16. Spitzer RL, Endicott J, Robins E (1978): Research diagnostic criteria: Rationale and reliability. Arch Gen Psychiatry 35:773-782.
17. Willner P (1995): Dopamine mechanisms in depression and mania. In Bloom FE, Kupfer DJ (eds): "Psychopharmacology: The Fourth Generation of Progress." New York: Raven Press, pp 921-931.