An examination of the association between DRD4 and DRD2 polymorphisms and personality traits

Personality and Individual Differences

Volumn 33, Issue 6, 2002, Pages 849-859

  Burt, S Alexandra ^a   McGue, Matt ^a   Iacono, William ^a   Comings, David ^b   MacMurray, James ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c Jerry L Pettis Memorial VA Medical Center   (United States)

Author keywords

DRD2; DRD4; Molecular; MPQ; Personality

Indexed keywords

EID: 0037136990     PISSN: 01918869     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0191-8869(01)00194-5     Document Type: Article

References (37)

1. Allison, D. B. (1997). Transmission-Disequilibrium Test for quantitative traits. American Journal of Human Genetics, 60, 676-690.
2. Asghari, V., Schoots, O., Van Kats, S., Ohara, K., Jovanovic, V., Guan, H., Bunzow, J. R., Petronis, A., & Van Tol, H. H. M. (1994). Dopamine D4 receptor repeat: analysis of different native and mutant forms of human and rat genes. Molecular Pharmacology, 46, 364-373.
3. Barr, C. L., & Kidd, K. K. (1993). Population frequencies of the A1 allele at the Dopamine D2 receptor locus. Biological Psychiatry, 34, 204-209.
4. Battaglia, M., Przybeck, T. R., Bellodi, L., & Cloninger, C. R. (1996). Temperament dimensions explain the comorbidity of psychiatric disorders. Comprehensive Psychiatry, 37, 292-298.
5. Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996). Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nature Genetics, 12, 81-84.
6. Benjamin, J., Osher, Y., Kotler, M., Gritsenko, I., Nemanov, L., Belmaker, R. H., & Ebstein, R. P. (2000). Association between tridimensional personality questionnaire (TPQ) and three functional polymorphisms: dopamine receptor D4 (DRD4), seratonin transporter promoter region (5-HTTLPR) and catechol O-methyltranferase (COMT). Molecular Psychiatry, 5, 96-100.
7. Bouchard, T. J. Jr. (1994). Genes, environment, and personality. Science, 264, 1700-1701.
8. Budowle, B., Chakiaborty, R., Giusti, A. M., Eisenberg, A. J., & Allen, P. C. (1991). Analysis of the VNTR locus D1S80 by the PCR following by high resolution PAGE. American Journal of Human Genetics, 48, 137-144.
9. Chang, F. M., Kidd, J. R., Livak, K. J., Pakstis, A. J., & Kidd, K. K. (1996). The worldwide distribution of allele frequencies at the human dopamine D4 receptor locus. Human Genetics, 98, 91-101.
10. Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants: a proposal. Archives of General Psychiatry, 44, 573-588.
11. Cloninger, C. R., Sigvardsson, S., Przybeck, T. R., & Svrakic, D. M. (1995). Personality antecedents of alcoholism in a national area probability sample. European Archives of Psychiatry & Clinical Neuroscience, 245, 239-244.
12. Comings, D. E. (1998). Why different rules are required for polygenic inheritance: lessons from studies of the DRD2 gene. Alcohol, 16, 61-70.
13. Comings, D. E., Gonzalez, N., Wu, S., Gade, R., Muhleman, D., Saucier, G., Johnson, P., Verde, R., Rosenthal, R. J., Lesieur, H. R., Rugle, L. J., Miller, W. R., & MacMurray, J. P. (1999). Studies of the 48 bp repeat of the DRD4 gene in impulsive-addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. American Journal of Medical Genetics (Neuropsychiatric Genetics), 88, 358-368.
14. Davis, G. L., Hoffman, R. G., & Nelson, K. S. (1990). Differences between native American and whites on the California Psychological Inventory. Psychological Assessment, 2, 238-242.
15. Eaves, L., & Meyer, J. (1994). Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behavior Genetics, 24, 443-455.
16. Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996). Dopamine D4 receptor (DRD4) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genetics, 12, 78-80.
17. Ekelund, J., Lichtermann, D., Järvelin, M., & Peltonen, L. (1999). Association between Novelty Seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. American Journal of Psychiatry, 156, 1453-1455.
18. Gebhardt, C., Leisch, F., Schussler, P., Fuchs, K., Stompe, T., Sieghart, W., Hornik, K., Kasper, S., & Aschauer, H. N. (2000). Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals. Psychiatric Genetics, 10, 131-137.
19. Grandy, D. K., Zhang, Y., & Ceveili, O. (1993). PCR detection of the Taq A RFLP at the DRD2 locus. Human Molecular Genetics, 2, 2197.
20. Hall, G. C. N., Bansal, A., & Lopez, I. R. (1999). Ethnicity and psychopathology: a meta-analytic review of 31 years of comparative MMPI/MMPI-2 research. Psychological Assessment, 11, 186-197.
21. Iacono, W. G., Carlson, S. R., Taylor, J., Elkins, I. J., & McGue, M. (1999). Behavioral disinhibition and the development of substance use disorders: findings from the Minnesota twin family study. Development & Psychopathology, 11, 869-900.
22. Jönsson, E. G., Nöthen, M. M., Gustavsson, J. P., Neidt, H., Brené , S., Tylec, A., Propping, P., & Sedvall, G. C. (1997). Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. American Journal of Psychiatry, 154, 697-699.
23. Jönsson, E. G., Nöthen, M. M., Gustavsson, J. P., Neidt, H., Forslund, K., Mattila-Evenden, M., Rylander, G., Propping, P., & Asberg, M. (1998). Lack of association between dopamine D4 receptor gene and personality traits. Psychological Medicine, 28, 985-989.
24. Krueger, R. F. (1999). Personality traits in late adolescence predict mental disorders in early adulthood: a prospective epidemiological study. Journal of Personality, 67, 39-64.
25. McGue, M. (in press). The genetics of personality. In Emery and Rimion's Principles and practice of medical genetics.
26. Mitsuyasu, H., Hirata, N., Sakai, Y., Shibata, H., Takeda, K., Ninomiya, H., Kawasaki, H., Tashiro, N., & Fukumaki, Y. (2001). Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits. Journal of Human Genetics, 46, 26-31.
27. Nanko, S., Hattori, M., Ikeda, K., Sasaki, T., Kazamatsuri, H., & Kuwata, S. (1993). Dopamine D4 receptor polymorphism and schizophrenia. Lancet, 341, 689-690.
28. Noble, E. P., Ozkaragoz, T. Z., Ritchie, T. L., Zhang, X., Belin, T. R., & Sparkes, R. S. (1998). D2 and D4 dopamine receptor polymorphisms and personality. American Journal of Medical Genetics, 81, 257-267.
29. Ono, Y., Manki, H., Yoshimura, K., Muramatsu, T., Mizushima, H., Higuchi, S., Yagi, G., Kanba, S., & Asai, M. (1997). Association between dopamine D4 receptor (DRD4) and exon III polymorphism and novelty seeking in Japanese subjects. American Journal of Medical Genetics, 74, 501-503.
30. Paterson, A. D., Sunohara, G. A., & Kennedy, J. L. (1999). Dopamine D4 receptor gene: novelty or nonsense? Neuropsychopharmacology, 21, 3-16.
31. Persson, M-L., Wasserman, D., Geijer, T., Frisch, A., Rockah, R., Michaelovsky, E., Apter, A., Weizman, A., Jönsson, E. G., & Bergman, H. (2000). Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers. European Archives of Psychiatry and Clinical Neuroscience, 250, 203-206.
32. Pogue-Geile, M., Ferrell, R., Deka, R., Debski, T., & Manuck, S. (1998). Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study. American Journal of Medical Genetics, 81, 44-48.
33. Strobel, A., Wehr, A., Michel, A., & Brocke, B. (1999). Association between the dopamine D4 receptor exon III polymorphism and measures of novelty seeking in a German population. Molecular Psychiatry, 4, 378-384.
34. Sullivan, P. F., Fifield, W. J., Kennedy, M. A., Mulder, R. T., Sellman, J. D., & Joyce, P. R. (1998). No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples. American Journal of Psychiatry, 155, 98-101.
35. Tellegen, A. (2000). Manual for the multidimensional personality questionnaire. Minneapolis, MN: University of Minnesota Press.
36. Vandenbergh, D. J., Zonderman, A. B., Wang, J., Uhl, G. R., & Costa, P. T. Jr. (1997). No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants. Molecular Psychiatry, 2, 417-419.
37. Waller, N. G., Lilienfeld, S. O., Tellegen, A., & Lykken, D. T. (1991). The tridimensional personality questionnaire: structural validity and comparison with the multidimensional personality questionnaire. Multivariate Behavioral Research, 26, 1-23.