Novel Endoperoxide Antimalarials: Synthesis, Heme Binding, and Antimalarial Activity

Journal of Medicinal Chemistry

Volumn 47, Issue 7, 2004, Pages 1833-1839

  Taylor, Dennis K ^a   Avery, Thomas D ^a   Greatrex, Ben W ^a   Tiekink, Edward R T ^b   Macreadie, Ian G ^c   Macreadie, Peter I ^c   Humphries, Adam D ^d   Kalkanidis, Martha ^d   Fox, Emma N ^d   Klonis, Nectarios ^d   Tilley, Leann ^d  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c CSIRO   (Australia)

^d LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE; ANTIMALARIAL AGENT; ARTEMISIN; CHLOROQUINE; ENDOPEROXIDE; HEME;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; OXIDATION; PHARMACOPHORE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; HEME; HUMANS; PEROXIDES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144289907     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0305319     Document Type: Article

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