The pH of the Plasmodium falciparum digestive vacuole: Holy grail or dead-end trail?

Trends in Parasitology

Volumn 18, Issue 10, 2002, Pages 441-444

  Spiller, David G ^a   Bray, Patrick G ^b   Hughes, Ruth H ^b   Ward, Stephen A ^b   White, Michael R H ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; CELL PROTEIN; CHLOROQUINE; DEXTRAN; DYE; FLUOROCHROME; HEME; HEMOGLOBIN;

ACIDITY; ANTIBIOTIC RESISTANCE; CELL VACUOLE; DETOXIFICATION; DIGESTION; MALARIA; NONHUMAN; PH; PLASMODIUM; PLASMODIUM FALCIPARUM; REVIEW;

ACRIDINE ORANGE; ANIMALS; ANTIMALARIALS; BENZOPYRANS; CHLOROQUINE; DRUG RESISTANCE; ERYTHROCYTES; FLUORESCENT DYES; HEMOGLOBINS; HUMANS; HYDROGEN-ION CONCENTRATION; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; VACUOLES;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0036791883     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4922(02)02365-6     Document Type: Review

References (27)

1. Rosenthal P.J., Meshnick S.R. Hemoglobin catabolism and iron utilization by malaria parasites. Mol. Biochem. Parasitol. 83:1996;131-139.
2. Pagola S., et al. The structure of malaria pigment beta haematin. Nature. 404:2000;307-310.
3. Rosenthal P.J. Proteases of protozoan parasites. Adv. Parasitol. 43:1999;105-159.
4. Tyas L., et al. Plasmepsins I and II from the malarial parasite Plasmodium falciparum. Adv. Exp. Med. Biol. 436:1998;407-411.
5. Eggelson K.K., Goldberg D.E. Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum. J. Biol. Chem. 274:1999;32411-32417.
6. Francis S.E., et al. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu. Rev. Microbiol. 51:1997;97-123.
7. Homewood C.A., et al. Lysosomes, pH and the anti-malarial action of chloroquine. Nature. 235:1972;50-52.
8. Geary T.G., et al. Uptake of [3H]chloroquine by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum. Biochem. Pharmacol. 35:1986;3805-3812.
9. Carlton J.M., et al. Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum. Curr. Opin. Microbiol. 4:2001;415-420.
10. Cowman A.F., et al. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole. J. Cell Biol. 113:1991;1033-1042.
11. Bray P.G., et al. Access to hematin: the basis of chloroquine resistance. Mol. Pharmacol. 54:1998;170-179.
12. Yayon A., et al. Susceptibility of human malaria parasites to chloroquine is pH dependent. Proc. Natl. Acad. Sci. U. S. A. 82:1985;2784-2788.
13. Dzekunov S.M., et al. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine. Mol. Biochem. Parasitol. 110:2000;107-124.
14. Ursos L.M., et al. The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine. Mol. Biochem. Parasitol. 110:2000;125-134.
15. Fidock D.A., et al. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell. 6:2000;861-871.
16. Mehlotra R.K., et al. Evolution of a unique Plasmodium falciparum chloroquine resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proc. Natl. Acad. Sci. U.S.A. 98:2001;12689-12694.
17. Richards D.F., et al. Detection of plasmodia by acridine orange stain. Tech. Bull. Regist. Med. Technol. 39:1969;4-7.
18. Ginsburg H., et al. Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity. Biochem. Pharmacol. 38:1989;2645-2654.
19. Bray P.G., et al. Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole Ph. Mol. Biochem. Parasitol. 119:2002;301-304.
20. Dzekunov S.M., et al. Response to Bray et al., 'Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH.'. Mol. Biochem. Parasitol. 119:2002;307-309.
21. Bray P.G., et al. Further comments on the distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH. Mol. Biochem. Parasitol. 119:2002;311-313.
22. Traganos F., Darzynkiewicz Z. Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol. 41:1994;185-194.
23. Bray P.G., et al. Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum. J. Cell Biol. 145:1999;363-376.
24. Haughland R.P. pH indicators. Spence M.T.Z., Handbook of Fluorescent Probes and Research Chemicals. 1996;566-567 Molecular Probes Inc.
25. Bray P.G., Ward S.A. A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum. Pharmacol. Ther. 77:1998;1-28.
26. Cooper R.A., et al. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol. Pharmacol. 61:2002;35-42.
27. Krugliak M., et al. Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins. Mol. Biochem. Parasitol. 119:2002;249-256.