Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues

Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2002, Pages 1052-1063

  Hindley, Stephen ^a   Ward, Stephen A ^a   Storr, Richard C ^a   Searle, Natalie L ^a   Bray, Patrick G ^a   Park, B Kevin ^a   Davies, Jill ^a   O'Neill, Paul M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

10BETA [2 (3 TRIFLUOROMETHYLPHENYLPIPERAZYL)ETHYL]DEOXOARTEMISININ; 10BETA [2 (4 CHLOROPHENYLPIPERAZYL)ETHYL]DEOXOARTEMISININ; 10BETA [2 (4 FLUOROPHENYLPIPERAZYL)ETHYL]DEOXOARTEMISININ; 10BETA [2 (4 NITROPHENYLPIPERAZYL)ETHYL]DEOXOARTEMISININ; 10BETA [2 (BENZYLPIPERAZYL)ETHYL]DEOXOARTEMISININ; 10BETA [2 (DI N PROPYLAMINO)ETHYL]DEOXOARTEMISININ; 10BETA [2 (N MORPHOLINO)ETHYL]DEOXOARTEMISININ; 10BETA [2 (PHENYLPIPERAZYL)ETHYL]DEOXOARTEMISININ; 10BETA [2 (PIPERIDINYL)ETHYL]DEOXOARTEMISININ; 10BETA [[3 [(3 TRIFLUOROMETHYLPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[3 [(4 CHLOROPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[3 [(4 FLUOROPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[3 [(4 NITROPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[3 [(PHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[4 [(4 FLUOROPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[4 [(4 NITROPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[4 [(4 TRIFLUOROMETHYLPHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[4 [(BENZYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; 10BETA [[4 [(PHENYLPIPERAZYL)METHYL]BENZYL]OXY]DIHYDROARTEMISININ; ALLYLDEOXOARTEMISININ; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTEMISININ DERIVATIVE; ARTESUNATE; CHLOROQUINE; DIAMINE DERIVATIVE; FERROUS ION; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DEGRADATION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MALARIA; MALE; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PROTON TRANSPORT;

ANIMALS; ANTIMALARIALS; ARTEMISININS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MALARIA; MALE; MICE; PIPERAZINES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SESQUITERPENES;

EID: 0037186497     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0109816     Document Type: Article

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