-
1
-
-
0032537990
-
Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
-
Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 1998;90:1371-88.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1371-1388
-
-
Fisher, B.1
Costantino, J.P.2
Wickerham, D.L.3
-
2
-
-
0035795683
-
Five versus more than five years of tamoxifen for lymph node-negative breast cancer: Updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial
-
Fisher B, Dignam J, Bryant J, Wolmark N. Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J Natl Cancer Inst 2001;93:684-90.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 684-690
-
-
Fisher, B.1
Dignam, J.2
Bryant, J.3
Wolmark, N.4
-
3
-
-
0036514255
-
Aromatase inhibitors in breast cancer
-
Brodie A. Aromatase inhibitors in breast cancer. Trends Endocrinol Metab 2002;13:61-5.
-
(2002)
Trends Endocrinol Metab
, vol.13
, pp. 61-65
-
-
Brodie, A.1
-
4
-
-
0030579801
-
Cloning of a novel estrogen receptor expressed in rat prostate and ovary
-
Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-A. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 1996;93:5925-30.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 5925-5930
-
-
Kuiper, G.G.J.M.1
Enmark, E.2
Pelto-Huikko, M.3
Nilsson, S.4
Gustafsson, J.-A.5
-
5
-
-
0033304993
-
The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
-
Hall JM, McDonnell DP. The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 1999;140:5566-78.
-
(1999)
Endocrinology
, vol.140
, pp. 5566-5578
-
-
Hall, J.M.1
McDonnell, D.P.2
-
6
-
-
0034705032
-
Estrogen receptor (ER) β, a modulator of ERα in the uterus
-
Weihua Z, Saji S, Mäkinen S, et al. Estrogen receptor (ER) β, a modulator of ERα in the uterus. Proc Natl Acad Sci U S A 2000;97:5936-41.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5936-5941
-
-
Weihua, Z.1
Saji, S.2
Mäkinen, S.3
-
7
-
-
0141525429
-
Evaluation of an estrogen receptor-β agonist in animal models of human disease
-
Harris HA, Albert LM, Leathurby Y, et al. Evaluation of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 2003;144:4241-9.
-
(2003)
Endocrinology
, vol.144
, pp. 4241-4249
-
-
Harris, H.A.1
Albert, L.M.2
Leathurby, Y.3
-
8
-
-
0029147741
-
Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ
-
Stein B, Yang MX. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ. Mol Cell Biol 1995;15:4971-9.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4971-4979
-
-
Stein, B.1
Yang, M.X.2
-
9
-
-
0041922555
-
Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
-
Vegeto E, Belcredito S, Etteri S, et al. Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci U S A 2003;100:9614-9.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9614-9619
-
-
Vegeto, E.1
Belcredito, S.2
Etteri, S.3
-
10
-
-
0026777433
-
Increased osteoclast development after estrogen loss: Mediation by interleukin-6
-
Jilka RL, Hangoc G, Girasole G, et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992;257:88-91.
-
(1992)
Science
, vol.257
, pp. 88-91
-
-
Jilka, R.L.1
Hangoc, G.2
Girasole, G.3
-
11
-
-
0344007515
-
Rapid extranuclear signaling by the estrogen receptor (ER): MNAR couples ER and Src to the MAP kinase signaling pathway
-
Edwards DP, Boonyaratanakornkit V. Rapid extranuclear signaling by the estrogen receptor (ER): MNAR couples ER and Src to the MAP kinase signaling pathway. Mol Interv 2003;3:12-5.
-
(2003)
Mol Interv
, vol.3
, pp. 12-15
-
-
Edwards, D.P.1
Boonyaratanakornkit, V.2
-
12
-
-
0033551139
-
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium
-
Improta-Brears T, Whorton AR, Codazzi F, York JD, Meyer T. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc Natl Acad Sci U S A 1999;96:4686-91.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4686-4691
-
-
Improta-Brears, T.1
Whorton, A.R.2
Codazzi, F.3
York, J.D.4
Meyer, T.5
-
13
-
-
0036013436
-
ERβ has nongenomic action in caveolae
-
Chambliss KL, Yuhanna IS, Anderson RGW, Mendelsohn ME, Shaul PW. ERβ has nongenomic action in caveolae. Mol Endocrinol 2002;16:938-46.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 938-946
-
-
Chambliss, K.L.1
Yuhanna, I.S.2
Anderson, R.G.W.3
Mendelsohn, M.E.4
Shaul, P.W.5
-
14
-
-
0000661662
-
The molecular pharmacology of SERMs
-
McDonnell DP. The molecular pharmacology of SERMs. Trends Endocrinol Metab 1999;10:301-11.
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 301-311
-
-
McDonnell, D.P.1
-
15
-
-
0023683768
-
Estradiol-stimulated growth of MCF-7 tumors implanted in athymic nude mice: A model to study the tumoristatic action of tamoxifen
-
Gottardis MM, Robinson SP, Jordan VC. Estradiol-stimulated growth of MCF-7 tumors implanted in athymic nude mice: a model to study the tumoristatic action of tamoxifen. J Steroid Biochem Mol Biol 1988;30:311-4.
-
(1988)
J Steroid Biochem Mol Biol
, vol.30
, pp. 311-314
-
-
Gottardis, M.M.1
Robinson, S.P.2
Jordan, V.C.3
-
16
-
-
0014053604
-
A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
-
Harper MJK, Walpole AL. A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J Reprod Fertil 1967;13:101-19.
-
(1967)
J Reprod Fertil
, vol.13
, pp. 101-119
-
-
Harper, M.J.K.1
Walpole, A.L.2
-
17
-
-
0026585852
-
Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer
-
Love RR, Mazess RB, Barden HS, et al. Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med 1992;326:852-6.
-
(1992)
N Engl J Med
, vol.326
, pp. 852-856
-
-
Love, R.R.1
Mazess, R.B.2
Barden, H.S.3
-
18
-
-
0033305547
-
Nuclear receptor coregulators: Cellular and molecular biology
-
McKenna NJ, Lanz RB, O'Malley BW. Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 1999;20:321-44.
-
(1999)
Endocr Rev
, vol.20
, pp. 321-344
-
-
McKenna, N.J.1
Lanz, R.B.2
O'Malley, B.W.3
-
19
-
-
2642544810
-
Estrogen receptor (ER) modulators each induce distinct conformational changes in ERα and ERβ
-
Paige LA, Christensen DJ, Grøn H, et al. Estrogen receptor (ER) modulators each induce distinct conformational changes in ERα and ERβ. Proc Natl Acad Sci U S A 1999;96:3999-4004.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3999-4004
-
-
Paige, L.A.1
Christensen, D.J.2
Grøn, H.3
-
20
-
-
0033305525
-
Comparative analyses of the mechanistic differences among antiestrogens
-
Wijayaratne AL, Nagel SC, Paige LA, et al. Comparative analyses of the mechanistic differences among antiestrogens. Endocrinology 1999;140:5828-40.
-
(1999)
Endocrinology
, vol.140
, pp. 5828-5840
-
-
Wijayaratne, A.L.1
Nagel, S.C.2
Paige, L.A.3
-
21
-
-
0033618510
-
Peptide antagonists of the human estrogen receptor
-
Norris JD, Paige LA, Christensen DJ, et al. Peptide antagonists of the human estrogen receptor. Science 1999;285:744-6.
-
(1999)
Science
, vol.285
, pp. 744-746
-
-
Norris, J.D.1
Paige, L.A.2
Christensen, D.J.3
-
22
-
-
0027521287
-
Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
-
Beekman JM, Allan GF, Tsai SY, Tsai M-J, O'Malley BW. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol Endocrinol 1993;7:1266-74.
-
(1993)
Mol Endocrinol
, vol.7
, pp. 1266-1274
-
-
Beekman, J.M.1
Allan, G.F.2
Tsai, S.Y.3
Tsai, M.-J.4
O'Malley, B.W.5
-
23
-
-
0033198735
-
Structure of the ligand-binding domain of oestrogen receptor β in the presence of a partial agonist and a full antagonist
-
Pike ACW, Brzozowski AM, Hubbard RE, et al. Structure of the ligand-binding domain of oestrogen receptor β in the presence of a partial agonist and a full antagonist. EMBO J 1999;18:4608-18.
-
(1999)
EMBO J
, vol.18
, pp. 4608-4618
-
-
Pike, A.C.W.1
Brzozowski, A.M.2
Hubbard, R.E.3
-
24
-
-
0035099225
-
Structural insights into the mode of action of a pure antiestrogen
-
Pike ACW, Brzozowski AM, Walton J, et al. Structural insights into the mode of action of a pure antiestrogen. Structure 2001;9:145-53.
-
(2001)
Structure
, vol.9
, pp. 145-153
-
-
Pike, A.C.W.1
Brzozowski, A.M.2
Walton, J.3
-
25
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau AK, Barstad D, Loria PM, et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 1998;95:927-37.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
-
26
-
-
0027319423
-
Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone
-
Smith CL, Conneely OM, O'Malley BW. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci U S A 1993;90:6120-4.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 6120-6124
-
-
Smith, C.L.1
Conneely, O.M.2
O'Malley, B.W.3
-
27
-
-
0029862869
-
Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol
-
Ignar-Trowbridge DM, Pimentel M, Parker MG, McLachlan JA, Korach KS. Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol. Endocrinology 1996;137:1735-44.
-
(1996)
Endocrinology
, vol.137
, pp. 1735-1744
-
-
Ignar-Trowbridge, D.M.1
Pimentel, M.2
Parker, M.G.3
McLachlan, J.A.4
Korach, K.S.5
-
28
-
-
0037420192
-
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer
-
Osborne CK, Bardou V, Hopp TA, et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst 2003;95:353-61.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 353-361
-
-
Osborne, C.K.1
Bardou, V.2
Hopp, T.A.3
-
29
-
-
0028840057
-
When tamoxifen turns bad
-
Horwitz KB. When tamoxifen turns bad. Endocrinology 1995;136:821-3.
-
(1995)
Endocrinology
, vol.136
, pp. 821-823
-
-
Horwitz, K.B.1
-
30
-
-
0029038986
-
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens
-
McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW. Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol 1995;9:659-68.
-
(1995)
Mol Endocrinol
, vol.9
, pp. 659-668
-
-
McDonnell, D.P.1
Clemm, D.L.2
Hermann, T.3
Goldman, M.E.4
Pike, J.W.5
-
31
-
-
1442351143
-
Coregulator function: A key to understanding tissue specificity of selective receptor modulators
-
Smith CL, O'Malley BW. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 2004;25:45-71.
-
(2004)
Endocr Rev
, vol.25
, pp. 45-71
-
-
Smith, C.L.1
O'Malley, B.W.2
-
32
-
-
0035929585
-
The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists and selective estrogen receptor modulators
-
Wijayaratne AL, McDonnell DP. The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists and selective estrogen receptor modulators. J Biol Chem 2001;276:35684-92.
-
(2001)
J Biol Chem
, vol.276
, pp. 35684-35692
-
-
Wijayaratne, A.L.1
McDonnell, D.P.2
-
33
-
-
0026726806
-
Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation
-
Allan GF, Leng X, Tsai SY, et al. Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. J Biol Chem 1992;267:19513-20.
-
(1992)
J Biol Chem
, vol.267
, pp. 19513-19520
-
-
Allan, G.F.1
Leng, X.2
Tsai, S.Y.3
-
34
-
-
0028861402
-
Response to a specific antiestrogen (ICI182,780) in tamoxifen-resistant breast cancer
-
Howell A, DeFriend D, Robertson J, Blamey R, Walton P. Response to a specific antiestrogen (ICI182,780) in tamoxifen-resistant breast cancer. Lancet 1995;345:29-30.
-
(1995)
Lancet
, vol.345
, pp. 29-30
-
-
Howell, A.1
DeFriend, D.2
Robertson, J.3
Blamey, R.4
Walton, P.5
-
35
-
-
0030946198
-
Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
-
Smith CL, Nawaz Z, O'Malley BW. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol 1997;11:657-66.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 657-666
-
-
Smith, C.L.1
Nawaz, Z.2
O'Malley, B.W.3
-
36
-
-
0030797902
-
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer
-
Anzick SL, Kononen J, Walker RL, et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997;277:965-8.
-
(1997)
Science
, vol.277
, pp. 965-968
-
-
Anzick, S.L.1
Kononen, J.2
Walker, R.L.3
-
37
-
-
1542346452
-
The use of selective estrogen receptor modulators and selective estrogen receptor down-regulators in breast cancer
-
Howell SJ, Johnston SRD, Howell A. The use of selective estrogen receptor modulators and selective estrogen receptor down-regulators in breast cancer. Best Pract Res Clin Endocrinol Metab 2004;18:47-66.
-
(2004)
Best Pract Res Clin Endocrinol Metab
, vol.18
, pp. 47-66
-
-
Howell, S.J.1
Johnston, S.R.D.2
Howell, A.3
-
38
-
-
0037192501
-
Molecular determinants for the tissue specificity of SERMs
-
Shang Y, Brown M. Molecular determinants for the tissue specificity of SERMs. Science 2002;295:2465-8.
-
(2002)
Science
, vol.295
, pp. 2465-2468
-
-
Shang, Y.1
Brown, M.2
-
39
-
-
0037112441
-
Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer
-
Ariazi EA, Clark GM, Mertz JE. Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res 2002;62:6510-8.
-
(2002)
Cancer Res
, vol.62
, pp. 6510-6518
-
-
Ariazi, E.A.1
Clark, G.M.2
Mertz, J.E.3
-
40
-
-
3042699992
-
Estrogen-related receptor α in human breast carcinoma as a potent prognostic factor
-
Suzuki T, Miki Y, Moriya T, et al. Estrogen-related receptor α in human breast carcinoma as a potent prognostic factor. Cancer Res 2004;64:4670-6.
-
(2004)
Cancer Res
, vol.64
, pp. 4670-4676
-
-
Suzuki, T.1
Miki, Y.2
Moriya, T.3
-
41
-
-
0042524273
-
Expression of peroxisome-proliferator activated receptor-gamma (PPARγ) and the PPARγ co-activator, PGC-1, in human breast cancer correlates with clinical outcomes
-
Jiang WG, Douglas-Jones A, Mansel RE. Expression of peroxisome- proliferator activated receptor-gamma (PPARγ) and the PPARγ co-activator, PGC-1, in human breast cancer correlates with clinical outcomes. Int J Cancer 2003;106:752-7.
-
(2003)
Int J Cancer
, vol.106
, pp. 752-757
-
-
Jiang, W.G.1
Douglas-Jones, A.2
Mansel, R.E.3
-
42
-
-
0035300412
-
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor
-
Connor CE, Norris JD, Broadwater G, et al. Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Res 2001;61:2917-22.
-
(2001)
Cancer Res
, vol.61
, pp. 2917-2922
-
-
Connor, C.E.1
Norris, J.D.2
Broadwater, G.3
-
43
-
-
0028263517
-
3-[4-(1,2-Diphenylbut-1-enyl) phenyl]acrylic acid: A non-steroidal estrogen with functional selectivity for bone over uterus in rats
-
Willson TM, Henke BR, Momtahen TM, et al. 3-[4-(1,2-diphenylbut-1-enyl) phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats. J Med Chem 1994;37:1550-2.
-
(1994)
J Med Chem
, vol.37
, pp. 1550-1552
-
-
Willson, T.M.1
Henke, B.R.2
Momtahen, T.M.3
-
44
-
-
0030741983
-
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of ER in bone
-
Willson TM, Norris JD, Wagner BL, et al. Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of ER in bone. Endocrinology 1997;138:3901-11.
-
(1997)
Endocrinology
, vol.138
, pp. 3901-3911
-
-
Willson, T.M.1
Norris, J.D.2
Wagner, B.L.3
-
45
-
-
0026395885
-
A potent specific pure antiestrogen with clinical potential
-
Wakeling AE, Dukes M, Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res 1991;51:3867-73.
-
(1991)
Cancer Res
, vol.51
, pp. 3867-3873
-
-
Wakeling, A.E.1
Dukes, M.2
Bowler, J.3
-
47
-
-
0036721523
-
Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol
-
Yue W, Wang J-P, Conaway M, Masamura S, Li Y, Santen RJ. Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol. Endocrinology 2002;143:3221-9.
-
(2002)
Endocrinology
, vol.143
, pp. 3221-3229
-
-
Yue, W.1
Wang, J.-P.2
Conaway, M.3
Masamura, S.4
Li, Y.5
Santen, R.J.6
|