Point mutation of 5′ noncoding region of BCL-6 gene in primary gastric lymphomas

World Journal of Gastroenterology

Volumn 11, Issue 1, 2005, Pages 51-55

  Min, Da Liu ^a   Zhou, Xiao Yan ^a   Yang, Wen Tao ^a   Lu, Hong Fen ^a   Zhang, Tai Ming ^a   Zhen, Ai Hua ^a   Cao, Pei Zheng ^a   Shi, Da Ren ^a  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

5 noncoding region; BCL 6 gene; Gastric lymphomas; Point mutation

Indexed keywords

DNA; PROTEIN BCL 6;

5' UNTRANSLATED REGION; ADULT; AMINO ACID SUBSTITUTION; ARTICLE; B CELL LYMPHOMA; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; HUMAN; HUMAN TISSUE; LARGE CELL LYMPHOMA; LYMPH NODE HYPERPLASIA; MALE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; STOMACH CARCINOGENESIS; STOMACH LYMPHOMA;

EID: 11844295345     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i1.51     Document Type: Article

References (50)

1. Ye BH, Rao PH, Chaganti RSK, Dalla-Favera R. Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res 1993; 53: 2732-2735
2. Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993; 262 747-750
3. Lo Coco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM, Chaganti RSK, Dalla-Favera R. Rearrangements of the Bcl-6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994; 83: 1757-1759
4. Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H. LAZ3 rearrangements in non-hodgkin's lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994; 83: 2423-2427
5. Bernardin F, Collyn-d'Hooghe M, Quief S, Bastard C, Leprince D, Kerckaert JP. Small deletions occur in highly conserved regions of the LAZ3/BCL 6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation. Oncogene 1997; 14: 849-855
6. Ye BH. Proto-oncogene BCL-6 and the pathogenesis of non-Hodgkin's lymphoma. Einstein quart. J Biol Med 1999; 16 130-143
7. Kramer MHH, Hermans J, Wijburg E, Philippo K, Geelen E, van Krieken JHJM, de Jong D, Maartense E, Schuuring E, Kluin PM. Clinical relevance of BCL 2, BCL 6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood 1998; 92: 3152-3162
8. Chen W, Butler M, Rao PH, Chaganti SR, Louie DC, Dalla-Favera R, Chaganti RSK. The t (2;3) (q21;q27) translocation in non-Hodgkin's lymphoma displays BCL 6 mutations in the 5′ regulatory region and chromosomal breakpoints distant from the gene. Oncogene 1998; 17: 1717-1722
9. Tamura A, Miura I, Iida S, Yokota S, Horiike S, Nishida K, Fujii H, Nakamura S, Seto M, Ueda R, Taniwaki M. Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma. Cancer Genet Cytogenet 2001; 129: 1-9
10. Sanchez-Izquierdo D, Siebert R, Harder L, Marugan I, Gozzetti A, Price HP, Gesk S, Hernandez-Rivas JM, Benet I, Solé F, Sonoki T, Le Beau MM, Schlegelberger B, Dyer MJS, Garcia-Conde J, Martinez-Climent JA. Detection of translocations affecting the BCL 6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization. Leukemia 2001; 15: 1475-1484
11. Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R. Frequent somatic hypermutation of the 5′ noncoding region of the BCL-6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A 1995; 92: 12520-12524
12. Gaidano G, Carbone A, Pastore C, Capello D, Migliazza A, Gloghini A, Roncella S, Ferrarini M, Saglio G, Dalla-Favera R. Frequent mutation of the 5′ noncoding region of the bcl-6 gene in acquired immunodeficiency syndrome-related non-hodgkin's lymphomas. Blood 1997; 89: 3755-3762
13. Lossos IS, Levy R. Mutation analysis of the 5′ noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity. Blood 2000; 95: 1400-1405
14. Capello D, Vitolo U, Pasqualucci L, Quattrone S, Migliaretti G, Fassone L, Ariatti C, Vivenza C, Gloghini A, Pastore C, Lanza C, Nomdedeu J, Botto B, Freilone R, Carbone A, Gaidano G. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia. Blood 2000; 95: 651-659
15. Vitolo U, Botto B, Capello D, Vivenza D, Zagonel V, Gloghini A, Novero D, Parvis G, Calvi R, Ariatti C, Milan I, Bertini M, Boccomini C, Freilone R, Pregno P, Orsucci L, Palestro G, Saglio G, Carbone A, Gallo E, Gaidano G. Point mutations of the BCL-6 gene: Clinical and prognostic correlation in B-diffuse large cell lymphoma. Leukemia 2002; 16: 268-275
16. Mascle X, Albagli O, Lemercier C. Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers. Biochem Biophys Res Commun 2003; 300: 391-396
17. Yavuz AS, Monson NL, Yavuz S, Grammer AC, Longo N, Girschick HJ, Lipsky PE. Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms. Mol Immunol 2002; 39: 485-493
18. Chen PM, Yang MH, Yu IT, Lin JT, Lin YC, Fan FS, Wang WS, Yen CC, Chiou TJ, Liu JH. Low incidence of BCL-6 gene alterations for diffuse large B-cell lymphomas in Taiwan Chinese. Cancer 2001; 94: 2635-2644
19. Lossos IS, Levy R. Higher-grade transformation of follicle center lymphoma is associated with somatic mutation of the 5′ noncoding regulatory region of the BCL-6 gene. Blood 2000; 96: 635-639
20. Artiga MJ, Sáez AI, Romero C, Sánchez-Beato M, Mateo MS, Navas C, Mollejo M, Piris MA. A short mutational hot spot in the first intron of BCL-6 is associated with increased BCL-6 expression and with longer overall survival in large B-cell lymphomas. Am J Pathol 2002; 160: 1371-1380
21. Capello D, Carbone A, Pastore C, Gloghini A, Saglio G, Gaidano G. Point mutations of the BCL-6 gene in Burkitt's lymphoma. Br J Haematol 1997; 99: 168-170
22. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Histopathology 2000; 36: 69-87
23. Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti RSK, Klein U, Kuppers R, Rajewsky K. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci U S A 1998; 95: 11816-11821
24. Peng HZ, Du MQ, Koulis A, Aiello A, Dogan A, Pan LX, Isaacson PG. Nonimmunoglobulin gene hypermutation in germinal center B cells. Blood 1999; 93: 2167-2172
25. Barth TFE, Döhner H, Möller P, Bentz M. Chromosomal aberrations in lymphomas of the gastrointestinal tract. Leuk Lymphoma 1999; 36: 25-32
26. Liang R, Chan WP, Kwong YL, Chan ACL, Xu WS, Au WY, Srivastava G, Ho FCS. BCL6 gene hypermutations in diffuse large B-cell lymphoma of primary gastric origin. Br J Haematol 1997; 99: 668-670
27. Gaidano G, Capello D, Gloghini A, Fassone L, Vivenza D, Ariatti C, Migliazza A, Saglio G, Carbone A. Frequent mutation of BCL 6 proto-oncogene in high grade, but not low grade, MALT lymphomas of the gastrointestinal tract. Haematologica 1999; 84: 582-588
28. Falini B, Fizzotti M, Pileri S, Liso A, Pasqualucci L, Flenghi L. bcl-6 protein expression in normal and neoplastic lymphoid tissues. Ann Oncol 1997; 8(Suppl 2): 101-104
29. Lossos IS, Jones CD, Warnke R, Natkunam Y, Kaizer H, Zehnder JL, Tibshirani R, Levy R. Expression of a single gene, BCL-6 strongly predicts survival in patients with diffuse large B-cell lymphoma. Blood 2001; 98: 945-951
30. Shaffer AL, Yu X, He YS, Boldrick J, Chan EP, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000; 13: 199-212
31. Dent AL, Vasanwala FH, Toney LM. Regulation of gene expression by the proto-oncogene BCL-6. Crit Rev Oncol Hematol 2002; 41: 1-9
32. Leval LD, Ferry JA, Falini B, Shipp M, Harris NL. Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma; evidence for derivation from germinal center B cells? Am J Surg Pathol 2001; 25: 1277-1282
33. Dogan A, Bagdi E, Munson P, Isaacson PG. CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol 2000; 24: 846-852
34. Hori M, Qi CF, Torrey TA, Huppi K, Morse HC 3rd. The bcl 6 locus is not mutated in mouse B-cell lineage lymphomas. Leuk Res 2002; 26: 739-743
35. Stamatopoulos K, Kosmas C, Belessi C, Stavroyianni N, Kyriazopoulos P, Papadaki T. Molecular insights into the immunopathogenesis of follicular lymphoma. Immunol Today 2000; 21: 298-305
36. Sakashita C, Fukuda T, Okabe S, Kobayashi H, Hirosawa S, Tokuhisa T, Miyasaka N, Miura O, Miki T. Cloning and characterization of the human BAZF gene, a homologue of the BCL 6 oncogene. Biochem Biophys Res Commun 2002; 291: 567-573
37. Ohashi K, Miki T, Hirosawa S, Aoki N. Characterization of the promoter region of human BCL-6 gene. Biochem Biophys Res Commun 1995; 214: 461-467
38. Hartatik T, Okada S, Okabe S, Arima M, Hatano M, Tokuhisa T. Binding of BAZF and BCL6 to STAT6-binding DNA sequences. Biochem Biophys Res Commun 2001; 284: 26-32
39. Gaidano G, Capello D, Cilia AM, Gloghini A, Perin T, Quattrone S, Migliazza A, Lo Coco F, Saglio G, Ascoli V, Carbone A. Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL 6: implications for disease pathogenesis and histogenesis. Genes Chromosomes Cancer 1999; 24 16-23
40. Capello D, Gaidano, G. Molecular pathophysiology of indolent lymphoma. Haematologica 2000; 85: 195-201
41. Zhou XY, Zhu WP, Zhang TM, Li XM, Jin AP, Sun MH, Zhu XZ. Mutation of 5′ noncoding region of the bcl-6 gene in diffuse large B cell lymphomas. Zhonghua Binglixue Zazhi 2003; 32: 10-13
42. Kwon MS, Go JH, Choi JS, Lee SS, Ko YH, Rhee JC, Ree HJ. Critical evaluation of Bcl-6 protein expression in diffuse large B-cell lymphoma of the stomach and small intestine. Am J Surg Pathol 2003; 27: 790-798
43. Go JH, Yang WI, Ree HJ. Mutational analysis of the 5′ noncoding region of the bcl-6 gene in primary gastric lymphomas. Mod Pathol 2001; 14: 410-414
44. Xue FB, Xu YY, Wan Y, Pan BR, Ren J, Fan DM. Association of H pylori infection with gastric carcinoma: a Meta analysis. World J Gastroenterol 2001; 7: 801-804
45. Morgner A, Miehlke S, Stolte M, Neubauer A, Alpen B, Thiede C, Klann H, Hierlmeier FX, Ell C, Ehninger G, Bayerdorffer E. Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pylori associated gastric low grade marginal zone B cell lymphoma of MALT type. World J Gastroenterol 2001; 7: 248-253
46. Mateo MS, Mollejo M, Villuendas R, Algara P, Sanchez-Beato M, Martinez P, Piris MA. Molecular heterogeneity of splenic marginal zone lymphomas: analysis of mutations in the 5′ non-coding region of the bcl-6 gene. Leukemia 2001; 15: 628-634
47. Maes M, Depardieu C, Dargent JL, Hermans M, Verhaeghe JL, Delabie J, Pittaluga S, Troufléau P, Verhest A, De Wolf-Peeters C. Primary low-grade B-cell lymphoma of MALT-type occurring in the liver: a study of two cases. J Hepatol 1997; 27: 922-927
48. Liang R, Chan WP, Kwong YL, Chan ACL, Xu WS, Srivastava G. Mutation of the 5′ noncoding region of the BCL-6 gene in low-grade gastric lymphoma of the mucosa-associated lymphoid tissue. Cancer Genet Cytogenet 1998; 102: 110-113
49. Starostik P, Greiner A, Schultz A, Zettl A, Peters K, Rosenwald A, Kolve M, Muller-Hermelink HK. Genetic aberrations common in gastric high-grade large B-cell lymphoma. Blood 2000; 95: 1180-1187
50. Yoshino T, Akagi T. Gastric low-grade mucosa-associated lymphoid tissue lymphomas: their histogenesis and high-grade transformation. Pathol Int 1998; 48: 323-331