Low incidence of BCL-6 gene alterations for diffuse large B-cell lymphomas in Taiwan Chinese

Cancer

Volumn 94, Issue 10, 2002, Pages 2635-2644

  Chen, Po Min ^a,b   Yang, Muh Hwa ^a,b   Yu, I Ting ^a,b   Lin, Jen Tsun ^a,b   Lin, Yu Chen ^a,b   Fan, Frank S ^a,b   Wang, Wei Shu ^a,b   Yen, Chueh Chuan ^a,b   Chiou, Tzeon Jye ^a,b   Liu, Jin Hwang ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

BCL 6; Diffuse large B cell lymphoma; Gene rearrangement; Mutation

Indexed keywords

PROTEIN BCL 6;

AGED; ARTICLE; B CELL LYMPHOMA; CANCER SURVIVAL; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; MUTATION RATE; NONHODGKIN LYMPHOMA; POINT MUTATION; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTHERN BLOTTING; TAIWAN;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; DNA-BINDING PROTEINS; FEMALE; GENE REARRANGEMENT; HUMANS; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL; MALE; MUTATION; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; TAIWAN; TRANSCRIPTION FACTORS;

EID: 0037093951     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10545     Document Type: Article

References (31)

1. Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma
2. The BTB/POZ domain: A new protein-protein interaction motif common to DNA- and actin-binding proteins
3. Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma
4. Significance of rearrangement of the BCL6 gene in B- cell lymphoid neoplasms
5. Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays
6. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma
7. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts
8. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma
9. Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas: Results of rearrangement and gene expression studies and a mutational analysis of coding region sequences
10. Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: Association with diffuse large-cell subtype
11. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma
12. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
13. Nonimmunoglobulin gene hypermutation in germinal center B cells
14. Frequent mutation of the 5′ noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome- related non-Hodgkin's lymphomas
15. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997
16. Detection of specific sequences among DNA fragments separated by gel electrophoresis
17. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
18. "Cold SSCP": A simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses
19. Chi-square correction for continuity
20. The Fisher exact test
21. Non-parametric estimation from incomplete observations
22. Conservatism of the approximation in the log-rank test for survival data or tumor incidence data
23. Regulation of BCL-6 gene expression in human myeloid/monocytoid leukemic cells
24. BCL-6 in the pathogenesis of non-Hodgkin's lymphoma
25. LAZ3 rearrangements in non-Hodgkin's lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients
26. PCR analysis of immunoglobulin heavy chain (IgH) and TcR-gamma chain gene rearrangements in the diagnosis of lymphoproliferative disorders: Results of a study of 525 cases
27. Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma
28. Nonimunoglobulin (non-Ig)/BCL6 gene fusion in different large B-cell lymphoma results in worse prognosis than Ig/BCL6
29. Mutation analysis of the 5′ noncoding regulatory region of the BCL-6 gene in non-Hodgkin lympohma: Evidence for recurrent mutations and intraclonal Heterogenecity
30. Somatic mutation of the 5′ noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma
31. Higher-grade transformation of follicle center lymphoma is associated with somatic mutation of the 5′ noncoding regulatory region of the BCL-6 gene