CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas

American Journal of Surgical Pathology

Volumn 24, Issue 6, 2000, Pages 846-852

  Dogan, Ahmet ^a   Bagdi, Eniko ^a   Munson, Philippa ^a   Isaacson, Peter G ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

BCL 6; CD10; Immunohistochemistry; Lymphoma

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; PROTEIN BCL 6;

ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FOLLICULAR LYMPHOMA; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOID HYPERPLASIA; MAJOR CLINICAL STUDY; MANTLE CELL LYMPHOMA; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; PROTEIN EXPRESSION;

BIOLOGICAL MARKERS; BIOPSY; BURKITT LYMPHOMA; DIAGNOSIS, DIFFERENTIAL; HISTOLOGICAL TECHNIQUES; HODGKIN DISEASE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; LYMPHOMA, SMALL CLEAVED-CELL, DIFFUSE; NEPRILYSIN; PARAFFIN; PROTO-ONCOGENE PROTEINS; SPLENIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0034125061     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200006000-00010     Document Type: Article

References (28)

1. Arber DA, Weiss LM. CD10, a review. Appl Immunohistochem 1997;5:125-40.
2. Baron BW, Nucifora G, McCabe N, Espinosa R, Le Beau MM, McKeithan TW. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci USA 1993;90:5262-6.
3. Bastard C, Deweindt C, Kerckaert JP, et al. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994;83:2423-7.
4. Cattoretti G, Chang CC, Cechova K, et al. BCL-6 protein is expressed in germinal-center B cells. Blood 1995;86:45-53.
5. Chan JK, Miller KD, Munson P, Isaacson PG. Immunostaining for cyclm D1 and the diagnosis of mantle cell lymphoma: is there a reliable method? Histopathology 1999;34:266-70.
6. Dogan A, Du MQ, Aiello A, et al. Follicular lymphomas contain a clonally linked but phenotypically distinct neoplastic B-cell population in the interfollicular zone. Blood 1998;91:4708-14.
7. Falini B, Bigerna B, Pasqualucci L, et al. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease. Blood 1996;87:465-71.
8. Fang JM, Finn WG, Hussong JW, Goolsby CL, Cubbon AR, Variakojis D. CD10 antigen expression correlates with the t(14;18) (q32;q21) major breakpoint region in diffuse large B-cell lymphoma. Mod Pathol 1999;12:295-300.
9. Flenghi L, Bigerna B, Fizzotti M, et al. Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region. Am J Pathol 1996;148:1543-55.
10. Flenghi L, Ye BH, Fizzotti M, et al. A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol 1995;147:405-11.
11. Gascoyne RD, Adomat SA, Krajewski S, et al. Prognostic significance of BCL-2 protein expression and BCL-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood 1997;90: 244-51.
12. Hill ME, MacLennan KA, Cunningham DC, et al. Prognostic significance of BCL-2 expression and BCL-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study. Blood 1996;88: 1046-51.
13. Isaacson PG, Wotherspoon AC, Diss T, Pan LX. Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 1991;15:819-28.
14. Jacobson JO, Wilkes BM, Kwaiatkowski DJ, Medeiros LJ, Aisenberg AC, Harris NL. BCL-2 rearrangements in de novo diffuse large cell lymphoma. Association with distinctive clinical features. Cancer 1993;72:231-6.
15. Jaffe ES. Hematopathology: integration of morphologic features and biologic markers for diagnosis. Mod Pathol 1999;12:109-15.
16. Kaufmann O, Rath B, Spath-Schwalbe E, Possinger K, Dietel M. Immunohistochemical detection of CD10 with monoclonal antibody 56C6 on paraffin sections. Am J Clin Pathol 1999;111:117-22.
17. Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat Genet 1993;5:66-70.
18. Kramer MH, Hermans J, Wijburg E. et al. Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood 1998;92:3152-62.
19. Lo C, Ye BH, Lista F, et al. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994;83:1757-9.
20. McIntosh GG, Lodge AJ, Watson P, et al. NCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissue. Am J Pathol 1999;154:77-82.
21. Offit K, Koduru PR, Hollis R, et al. 18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance Br J Haematol 1989;72:178-83.
22. Offit K, Lo C, Louie DC, et al. Rearrangement of the BCL-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med 1994;331:74-80.
23. Onizuka T, Moriyama M, Yamochi T, et al. BCL-6 gene product, a 92-to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 1995;86:28-37.
24. Otsuki T, Yano T, Clark HM, et al. Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas: results of rearrangement and gene expression studies and a mutational analysis of coding region sequences. Blood 1995;85:2877-84.
25. Raible MD, His ED, Alkan S. BCL-6 protein expression by follicle center lymphomas. A marker for differentiating follicle center lymphomas from other lymphoproliferative disorders. Am J Clin Pathol 1999;112:101-7.
26. Ree HJ, Kadin ME, Kikuchi M, Ko YH, Suzumiya J, Go JH. BCL-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma. Hum Pathol 1999;30:403-11.
27. Tang SC, Visser L, Hepperle B, Hanson J, Poppema S. Clinical significance of BCL-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases. J Clin Oncol 1994;12:149-54.
28. Ye BH, Rao PH, Chaganti RS, Dalla-Favera R. Cloning of BCL-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res 1993;53:2732-5.