Frequent mutation of bcl-6 proto-oncogene in high grade, but not low grade, MALT lymphomas of the gastrointestinal tract

Haematologica

Volumn 84, Issue 7, 1999, Pages 582-588

  Gaidano, Gianluca ^a   Capello, Daniela ^a   Gloghini, Annunziata ^b   Fassone, Lucia ^a   Vivenza, Daniela ^a   Ariatti, Cristiano ^a   Migliazza, Anna ^c   Saglio, Giuseppe ^d   Carbone, Antonino ^b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

BCL 6; Lymphoma; Mucosa associated lymphoid tissue; Mutation; Proto oncogene

Indexed keywords

PROTEIN BCL 6; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; DNA SEQUENCE; GASTROINTESTINAL TUMOR; GENE MUTATION; HUMAN; HUMAN TISSUE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; POLYMERASE CHAIN REACTION;

DNA-BINDING PROTEINS; GASTROINTESTINAL NEOPLASMS; GENE FREQUENCY; HUMANS; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; TRANSCRIPTION FACTORS;

EID: 0032788706     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Isaacson PG, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer 1983; 52:1410-6.
2. Dragosics B, Bauer P, Radaskiewicz T. Primary gastrointestinal non-Hodgkin's lymphomas: a retrospective clinicopathologic study of 150 cases. Cancer 1985; 55:1060-73.
3. Cogliatti S, Schmid U, Schumaker U, et al. Primary gastric lymphoma: a clinicopathologic study of 145 patients. Gastroenterology 1991; 101:1159-70.
4. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 1994; 84:1361-92.
5. Fagioli F, Rigolin GM, Cuneo A, et al. Primary gastric lymphoma: distribution and clinical relevance of different epidemiological factors. Haematologica 1994; 79:213-7.
6. Zinzani PL, Magagnoli M, Pagliani G, et al. Primary intestinal lymphoma: clinical and therapeutic features of 32 patients. Haematologica 1997; 82:305-8.
7. De Jong D, Boot H, Van Heerde P, Hart GAM, Taal BG. Histological grading in gastric lymphoma: pre-treatment criteria and clinical relevance. Gastroenterology 1997; 112:1466-74.
8. th ed. Philadelphia: Lippincott; 1997. p. 2131-45.
9. Garcia-Sanz R, Vargas Montero M, Gonzalez Diaz M, et al. Detection of single and associated lesions of the Bcl-1, Bcl-2, Bcl-6, c-myc, p53 and p16 genes in B-cell non-Hodgkin's lymphomas: value of molecular analysis for a better assignment of the histologic subtype. Haematologica 1998; 83:209-16.
10. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991; 338: 1175-6.
11. Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993; 342:575-7.
12. Hussell T, Isaacson PG, Crabtree JE, Dogan A, Spencer J. Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. Am J Pathol 1993; 142: 285-92.
13. Parsonnet J, Hansen S, Rodriguez L, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994; 330:1267-71.
14. Qin Y, Greiner A, Trunk MJF, Schmausser B, Ott MM, Müller-Hermelink K. Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Blood 1995; 86:3528-34.
15. Bertoni F, Cazzaniga G, Bosshard G, et al. Immunoglobulin heavy chain diversity genes rearrangement pattern indicates that MALT-type gastric lymphoma B cells have undergone an antigen selection process. Br J Haematol 1997; 97:830-6.
16. Hallas C, Greiner A, Peters K, Müller-Hermelink HK. Immunoglobulin VH genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation. Lab Invest 1998; 78: 277-87.
17. Pan L, Diss TC, Cunningham D, Isaacson PG. The bcl-2 gene in primary B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Am J Pathol 1989; 135: 7-11.
18. Wotherspoon AC, Pan LX, Diss TC, Isaacson PG. A genotypic study of low-grade B-cell lymphomas, including lymphomas of mucosa-associated lymphoid tissue (MALT). J Pathol 1990; 162:135-40.
19. Du M, Peng H, Singh N, Isaacson PG, Pan L. The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood 1995; 86:4587-93.
20. Gaidano G, Volpe G, Pastore C, et al. Detection of BCL-6 rearrangements and p53 mutations in MALT-lymphomas. Am J Hematol 1997; 56:206-13.
21. Neumeister P, Hoefler G, Beham-Schmid C, et al. Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas. Gastroenterology 1997; 112:1871-5.
22. Ye BH, Lista F, Lo Coco F, Knowles DM, Chaganti RSK, Dalla-Favera R. Alterations of BCL-6, a novel zinc-finger gene, in diffuse large cell lymphoma. Science 1993; 262:747-50.
23. Kerchaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring 3q27 translocations in human lymphomas. Nature Genet 1993; 5:66-70.
24. Lo Coco F, Ye BH, Lista F, et al. Rearrangements of the BCL-6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994; 83:1757-9.
25. Migliazza A, Martinotti S, Chen W, et al. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 1995; 92:12520-4.
26. Capello D, Carbone A, Pastore C, Gloghini A, Saglio G, Gaidano G. Point mutations of the BCL-6 gene in Burkitt's lymphoma. Br J Haematol 1997; 99:168-70.
27. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997; 276: 589-92.
28. Gaidano G, Carbone A, Pastore C, et al. Frequent mutation of the 5′ noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. Blood 1997; 89: 3755-62.
29. Ye BH, Cattoretti G, Shen Q, et al. The BCL-6 protooncogene controls germinal-centre formation and Th2-type inflammation. Nature Genet 1997; 16:161-70.
30. Ye BH, Chaganti S, Chang CC, et al. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J 1995; 14:6209-17.
31. Shen HM, Peters A, Baron B, Zhu X, Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 1998; 280:1750-2.
32. Pasqualucci L, Migliazza A, Fracchiolla N, et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside immunoglobulin loci. Proc Natl Acad Sci USA 1998; 95:11816-21.
33. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988; 16:1215.
34. Sambrook J, Fritsh E, Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
35. Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983; 132:6-13.
36. Gaidano G, Lo Coco F, Ye BH, et al. Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: association with diffuse large-cell subtype. Blood 1994; 84:397-402.
37. Flenghi L, Ye BH, Fizzotti M, et al. A specific monoclonal antibody (PC-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol 1995; 147:405-11.
38. Carbone A, Gaidano G, Gloghini A, et al. BCL-6 protein expression in AIDS-related non-Hodgkin's lymphomas. Am J Pathol 1997; 150:155-65.
39. Migliazza A, Ye BH, Fracchiolla N, et al. Mutations of the 5′ non-coding region of BCL-6 are common in B cell malignancies and can deregulate BCL-6 expression. Blood 1997; 90 (suppl. 1):177a.
40. Omonishi K, Yoshino D, Sakuma I, Kobayashi K, Moriyama M, Akagi T. bcl-6 protein is identified in high-grade but not low-grade mucosa-associated lymphoid tissue lymphomas of the stomach. Mod Pathol 1998; 11:181-5.