Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: Evidence for derivation from germinal center B cells?

American Journal of Surgical Pathology

Volumn 25, Issue 10, 2001, Pages 1277-1282

  De Leval, L ^a   Ferry, J A ^a   Falini, B ^a   Shipp, M ^a   Harris, N L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Bcl 6; CD 10; Diffuse large B cell lymphoma; Germinal center; Mediastinum; Thymus

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; PROTEIN BCL 6;

ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CLINICAL ARTICLE; DERIVATIZATION; FEMALE; GENE MUTATION; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOPHENOTYPING; LARGE CELL LYMPHOMA; MALE; MEDIASTINUM TUMOR; MOLECULAR GENETICS; PROTEIN EXPRESSION; SOMATIC MUTATION; TISSUE FIXATION;

ADOLESCENT; ADULT; AGED; CELL COUNT; DNA-BINDING PROTEINS; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL; MALE; MEDIASTINAL NEOPLASMS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; NEPRILYSIN; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; THYMUS GLAND; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0034811146     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200110000-00008     Document Type: Article

References (44)

1. Classification of non-hodgkin's lymphoma by the non-hodgkin's lymphoma classification project
2. Large cell lymphoma of the mediastinum: A B-cell tumour of probable thymic origin
3. Primary anterior mediastinal B-cell lymphoma: A clinicopathologic and immunohistochemical study of 16 cases
4. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
5. Distribution and pattern of bcl-6 mutations throughout the spectrum of B-cell neoplasia
6. Bcl-6 protein is expressed in germinal-center B cells
7. Primary large-cell lymphoma of the thymus: A diffuse B-cell neoplasm presenting as primary mediastinal lymphoma
8. CD10 and bcl-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas
9. Bcl-6 protein expression in normal and neoplastic lymphoid tissues
10. Mediastinal large B-cell lymphoma: Clinical and immunohistological findings of 18 patients with two different third generation regimens
11. Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region
12. A revised european-american classification of lymphoid neoplasms: A proposal from the international lymphoma study group
13. CD30 expression is common in mediastinal large B-cell lymphoma
14. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma
15. The human thymus contains a novel population of B lymphocytes
16. Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B-cell lymphomas
17. B-cell lymphoma of probable thymic origin/case report
18. Immunohistochemical detection of CD10 with monoclonal antibody 56C6 on paraffin sections
19. Variable region gene analysis of B cell subsets derived from a 4-year-old child: Somatically mutated memory B cells accumulate in the peripheral blood already at young age
20. Cellular origin of human B-cell lymphomas
21. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression
22. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
23. Primary large cell lymphoma of the mediastinum: A histologic and immunophenotypic study of 29 cases
24. Primary non-hodgkin's lymphoma of the mediastinum
25. Rearrangements of the BCL6 gene in diffuse large cell non-hodgkin's lymphoma
26. NCL-CDI0-270: A new monoclonal antibody recognizing CD10 in paraffin-embedded tissue
27. Mediastinal large-cell lymphoma of B-cell type, with sclerosis: Histopathological and immunohistochemical study of eight cases
28. The prevalence and age distribution of human thymic B lymphoid follicles
29. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma
30. Immunophenotypic similarities of mediastinal clear-cell lymphoma and sinusoidal (monocytoid) B cells
31. Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation
32. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts
33. Analysis of somatic mutation in five B cell subsets of human tonsil
34. Mediastinal diffuse large-cell lymphoma with sclerosis: A clinicopathologic study of 60 cases
35. BCL-6 expression in reactive lymphoid tissue and in B-cell non-hodgkin's lymphomas
36. Bcl-6 protein expression by follicle center lymphomas: A marker for differentiating follicle center lymphomas from other low-grade lymphoproliferative disorders
37. Molecular features of primary mediastinal B-cell lymphoma: Involvement of p16INK4A, p53 and c-myc
38. Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: Correlation with 3q27 and 18q21 chromosomal abnormalities
39. Updated kiel classification for lymphomas
40. Diffuse large cell lymphomas of B and T cell type
41. Diffuse large cell undifferentiated lymphomas with prominent mediastinal involvement: A poor prognosis subset of patients with nonhodgkin's lymphoma
42. Molecular characterization of primary mediastinal B cell lymphoma
43. Primary large cell lymphomas of the mediastinum: An analysis of 20 cases