Chapter 5. Superallergens: A novel mechanism of IgE-mediated activation of human basophils and mast cells

Clinical and Experimental Allergy Reviews

Volumn 4, Issue SUPPL. 2, 2004, Pages 64-75

  Marone, Gianni ^a   Rossi, F W ^a   Bova, M ^a   Detoraki, A ^a   Liccardo, B ^a   Petraroli, A ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Basophils; Cysteinyl leukotriene C4; Histamine; IL 13; IL 4; Superallergens

Indexed keywords

ALLERGEN; BACTERIAL PROTEIN; CD4 ANTIGEN; CYTOKINE; FC RECEPTOR; GAMMA INTERFERON; GLYCOPROTEIN GP 120; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 13; INTERLEUKIN 4; LEUKOTRIENE C4; PARAPROTEIN; PROTEIN A; PROTEIN L; SUPERALLERGEN; SUPERANTIGEN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLERGIC REACTION; BASOPHIL; CELL ACTIVATION; CONFERENCE PAPER; CYTOKINE RELEASE; HISTAMINE RELEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGLOBULIN VARIABLE REGION; INFLAMMATION; MAST CELL; MEDIATOR RELEASE; PATHOPHYSIOLOGY; PEPTOSTREPTOCOCCUS; PEPTOSTREPTOCOCCUS MAGNUS; PRIORITY JOURNAL; PROTEIN FV; PROTEIN INDUCTION; STAPHYLOCOCCUS AUREUS;

EID: 11844281540     PISSN: 14729725     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-9725.2004.00036.x     Document Type: Conference Paper

References (95)

1. Silverman GJ. B-cell superantigens. possible roles in immunodeficiency and autoimmunity. Semin Immunol 1998; 10:43-55.
2. Silverman GJ. B-cell superantigens. Immunol Today 1997; 18:379-86.
3. 2 fragment of human IgG. Scand J Immunol 1980; 12:23-31.
4. Graille M, Stura EA, Corper AL et al. Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity. Proc Natl Acad Sci USA 2000; 97:5399-404.
5. Townsley-Fuchs J, Neshat MS, Margolin DH, Braun J, Goodglick L. HIV-1 gp120: a novel viral B cell superantigen. Int Rev Immunol 1997; 14:325-38.
6. Guihard AI, Pires R, Bouvet J-P. An endogenous superantigen in the rat gut lumen as a model to study the role of human protein-Fv. Scand J Immunol 1997; 45:36-42.
7. Björck L, Protein L. A novel bacterial cell wall protein with affinity for Ig L chains. J Immunol 1988; 140:1194-7.
8. Marone G, Lichtenstein LM, Galli SJ. Mast Cells and Basophils. San Diego: Academic Press, 2000.
9. Romagnani P, de Paulis A, Beltrame C et al. Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Am J Pathol 1999; 155:1195-204.
10. de Paulis A, Minopoli G, Arbustini E et al. Stem cell factor is localized in, released from, and cleaved by human mast cells. J Immunol 1999; 163:2799-808.
11. Casolaro V, Galeone D, Giacummo A, Sanduzzi A, Melillo G, Marone G. Human basophil/mast cell releasability. V. Functional comparisons of cells obtained from peripheral blood, lung parenchyma, and bronchoalveolar lavage in asthmatics. Am Rev Respir Dis 1989; 139:1375-82.
12. MacGlashan D Jr, White JM, Huang S-K, Ono SJ, Schroeder JT, Lichtenstein LM. Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 1994; 152:3006-16.
13. Patella V, Marino I, Lampärter B, Arbustini E, Adt M, Marone G. Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. J Immunol 1995; 154:2855-65.
14. H3 region of IgE. J Immunol 1998; 161:5647-55.
15. Lichtenstein LM, Kagey-Sobotka A, White JM, Hamilton RG. Anti-human IgG causes basophil histamine release by acting on IgG-IgE complexes bound to IgE receptors. J Immunol 1992; 148:3929-36.
16. Marone G. Asthma: recent advances. Immunol Today 1998; 19:5-9.
17. Lee WM. Hepatitis B virus infection. N Engl J Med 1997; 337:1733-45.
18. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345:41-52.
19. Popp JW Jr, Harrist TJ, Dienstag JL et al. Cutaneous vasculitis associated with acute and chronic hepatitis. Arch Intern Med 1981; 141:623-9.
20. Segool RA, Lejtenyi C, Taussig LM. Articular and cutaneous prodromal manifestations of viral hepatitis. J Pediatr 1975; 87:709-12.
21. Vaida GA, Goldman MA, Bloch KJ. Testing for hepatitis B virus in patients with chronic urticaria and angioedema. J Allergy Clin Immunol 1983; 72:193-8.
22. Miadonna A, Tedeschi A, Leggieri E, Invernizzi F, Zanussi C. Basophil activation in idiopathic mixed cryoglobulinemia. J Clin Immunol 1982; 2:309-13.
23. Bouvet J-P, Pirès R, Lunel-Fabiani F et al. A novel F (ab) -binding factor, present in normal liver, and largely released in the digestive tract during hepatitis. J Immunol 1990; 145:1176-80.
24. Bouvet J-P, Pirès R, Charlemagne J, Pillot J, Iscaki S. Non-immune binding of human protein Fv to immunoglobulins from various mammalian and non-mammalian species. Scand J Immunol 1991; 34:491-6.
25. Bouvet J-P, Pirès R, Iscaki S, Pillot J. Nonimmune macro-molecular complexes of Ig in human gut lumen. Probable enhancement of antibody functions. J Immunol 1993; 151:2562-72.
26. Sharma MD, Maillard P, Vrati S et al. Serial passage of west-european sporadic non-A non-B hepatitis in rhesus monkeys by inoculation with fecal extracts. J Med Virol 1990; 30:36-41.
27. H-binding specificity of human protein Fv. Scand J Immunol 1991; 33:381-6.
28. Patella V, Bouvet J-P, Marone G. Protein Fv produced during viral hepatitis is a novel activator of human basophils and mast cells. J Immunol 1993; 151:5685-98.
29. Del Prete G, Maggi E, Parronchi P et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988; 140:4193-8.
30. Peters CJ, Johnson KM. Serum immunoglobulin levels in Australia antigen positive and Australia antigen negative hepatitis. Clin Exp Immunol 1972; 11:381-91.
31. Van Epps E, Husby G, Williams RC Jr, Strickland RG. Liver disease - a prominent cause of serum IgE elevation. Clin Exp Immunol 1976; 23:444-50.
32. Fauci AS. The AIDS epidemic. Considerations for the 21st century. N Engl J Med 1999; 341:1046-50.
33. Marone G, Austen KF, Holgate ST, Kay AB, Lichtenstein LM, eds. Asthma and Allergic Diseases. Physiology, Immunopharmacology and Treatment. London: Academic Press, 1998.
34. Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol 2000; 105:399-408.
35. Viganò A, Principi N, Crupi L, Onorato J, Zuccotti GV, Salvaggio A. Elevation of IgE in HIV-infected children and its correlation with the progression of disease. J Allergy Clin Immunol 1995; 95:627-32.
36. Viganò A, Principi N, Villa ML et al. Immunologic characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression. J Pediatr 1995; 126:368-74.
37. Koutsonikolis A, Nelson RP, Fernandez-Caldas E et al. Serum total and specific IgE levels in children infected with human immunodeficiency virus. J Allergy Clin Immunol 1996; 97:692-7.
38. Secord EA, Kleiner GI, Auci DL et al. IgE against HIV proteins in clinically healthy children with HIV disease. J Allergy Clin Immunol 1996; 98:979-84.
39. Bacot BK, Paul ME, Navarro M et al. Objective measures of allergic disease in children with human immunodeficiency virus infection. J Allergy Clin Immunol 1997; 100:707-11.
40. Onorato J, Esposito S, Scovena E et al. Eosinophil involvement and serum IgE level in HIV-1-infected children. J Allergy Clin Immunol 1999; 104:245-7.
41. + T-cells. AIDS Res Hum Retroviruses 1990; 6:427-9.
42. Wright DN, Nelson RP Jr, Ledford DK, Fernandez-Caldas E, Trudeau WL, Lokey RF. Serum IgE and human immunodeficiency virus (HIV) infection. J Allergy Clin Immunol 1990; 85:445-52.
43. Miguez-Burbano MJ, Shor-Posner G, Fletcher MA et al. Immunoglobulin E levels in relationship to HIV-1 disease, route of infection, and vitamin E status. Allergy 1995; 50:157-61.
44. Shor-Posner G, Miguez-Burbano MJ, Lu Y et al. Elevated IgE level in relationship to nutritional status and immune parameters in early human immunodeficiency virus-1 disease. J Allergy Clin Immunol 1995; 95:886-92.
45. Paganelli R, Scala E, Mezzaroma I et al. Immunologic aspects of hyperimmunoglobulinemia E-like syndrome in patients with AIDS. J Allergy Clin Immunol 1995; 95:995-1003.
46. Agarwal SK, Marshall GD Jr. In vivo alteration in type-1 and type-2 cytokine balance: a possible mechanism for elevated total IgE in HIV-infected patients. Hum Immunol 1998; 59:99-105.
47. Rancinan C, Morlat P, Chêne G et al. IgE serum level: a prognostic marker for AIDS in HIV-infected adults? J Allergy Clin Immunol 1998; 102:329-30.
48. Clerici M, Hakim FT, Venzon DJ et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest 1993; 91:759-65.
49. Barcellini W, Rizzardi GP, Borghi MO, Fain C, Lazzarin A, Meroni PL. TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994; 8:757-62.
50. + T-cell clones in human immunodeficiency virus infection. Blood 1994; 84:4262-8.
51. Klein SA, Dobmeyer JM, Dobmeyer TS et al. Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry. AIDS 1997; 11:1111-8.
52. Zou W, Dulioust R, Fior R et al. Increased T-helper-type 2 cytokine production in chronic HIV infection is due to interleukin (IL)-13 rather than IL-4. AIDS 1997; 11:533-4.
53. Kovacs JA, Hiemenz JW, Macher AM et al. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med 1984; 100:663-71.
54. Kaplan MH, Sadick N, McNutt NS, Meltzer M, Sarnagadharan MG, Pahwa S. Dermatologic findings and manifestations of acquired immunodeficiency syndrome (AIDS). J Am Acad Dermatol 1987; 16:485-506.
55. Coopman SA, Johnson RA, Platt R, Stern RS. Cutaneous disease and drug reactions in HIV infection. N Engl J Med 1993; 328:1670-4.
56. Milazzo F, Piconi S, Trabattoni D et al. Intractable pruritus in HIV infection: immunologic characterization. Allergy 1999; 54:266-72.
57. Kowalski M, Potz J, Basiripour L et al. Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science 1987; 237:1351-5.
58. Lu M, Blacklow SC, Kim PS. A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nat Struct Biol 1995; 2:1075-82.
59. Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 1998; 393:648-59.
60. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272:872-7.
61. Karray S, Zouali M. Identification of the B cell superantigen-binding site of HIV-1 gp120. Proc Natl Acad Sci USA 1997; 94:1356-60.
62. Karray S, Juompan L, Maroun RC, Isenberg D, Silverman GJ, Zouali M. Structural basis of the gp120 superantigen-binding site on human immunoglobulins. J Immunol 1998; 161:6681-8.
63. H3 gene products: natural ligands for HIV gp120. Science 1993; 261:1588-91.
64. H3 region of IgE. J Immunol 2000; 164:589-95.
65. Florio G, Petraroli A, Patella V, Triggiani M, Marone G. The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. AIDS 2000; 14:931-8.
66. + cells in HIV-1 infection. Immunol Rev 2001; 179:128-38.
67. Gelderblom HR, Hausmann EHS, Özel M, Pauli G, Koch MA. Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virology 1987; 156:171-6.
68. Israël-Biet D, Labrousse F, Tourani J-M, Sors H, Andrieu J-M, Even P. Elevation of IgE in HIV-infected subjects: a marker of poor prognosis. J Allergy Clin Immunol 1992; 89:68-75.
69. Forsgren A, Sjöquist J. Protein A from S. aureus. I. Pseudo-immune reaction with human γ-globulin. J Immunol 1966; 97:822-7.
70. 2ε protein A interactions. Scand J Immunol 1981; 13:343-52.
71. Marone G, Poto S, Petracca R et al. Activation of human basophils by staphylococcal protein A. I. The role of cyclic AMP, arachidonic acid metabolites, microtubules and microfilaments. Clin Exp Allergy 1982; 50:661-8.
72. Marone G, Tamburini M, Giudizi MG, Biagiotti R, Almerigogna F, Romagnani S. Mechanism of activation of human basophils by Staphylococcus aureus Cowan 1. Infect Immun 1987; 55:803-9.
73. Franklin DL. Staphylococcus aureus infections. N Engl J Med 1998; 339:520-32.
74. Leung DY, Hauk P, Strickland I, Travers JB, Norris DA. The role of superantigens in human diseases: therapeutic implications for the treatment of skin diseases. Br J Dermatol 1998; 53:17-29.
75. Genovese A, Bouvet J-P, Florio G, Lamparter-Schummert B, Björck L, Marone G. Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. Infect Immun 2000; 68:5517-24.
76. Sjöholm I, Bjerken A, Sjöquist J. Protein A from Staphylococcus aureus. XIV. The effect of nitration of protein A with tetranitromethane and subsequent reduction. J Immunol 1973; 110:1562-9.
77. H3 immunoglobulin binding to staphylococcal protein A. J Exp Med 1993; 178:331-6.
78. Kastern W, Sjöbring U, Björck L. Structure of peptostreptococcal protein L and identification of a repeated immunoglobulin light chain-binding domain. J Biol Chem 1992; 267:12820-5.
79. Ricci S, Medaglini D, Marcotte H, Olsen A, Pozzi G, Björck L. Immunoglobulin-binding domains of peptostreptococcal protein L enhance vaginal colonization of mice by Streptococcus gordonii. Microb Pathog 2001; 30:229-35.
80. Akerström B, Björck L. Protein L: an immunoglobulin light chain-binding bacterial protein. Characterization of binding and physicochemical properties. J Biol Chem 1989; 264:19740-6.
81. Beckingham JA, Bottomley SP, Hinton R, Sutton BJ, Gore MG. Interactions between a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus and a human kappa light chain. Biochem J 1999; 340:193-9.
82. Graille M, Stura EA, Housden NG et al. Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins. Structure 2001; 9:679-87.
83. Nilson BHK, Solomon A, Björck L, Akerström B. Protein L from Peptostreptococcus magnus binds to the κ light chain variable domain. J Biol Chem 1992; 267:2234-9.
84. Axcrona K, Björck L, Leanderson T. Multiple ligand interactions for bacterial immunoglobulin-binding proteins on human and murine cells of the hematopoetic lineage. Scand J Immunol 1995; 42:359-67.
85. Patella V, Casolaro V, Björck L, Marone G. Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells. J Immunol 1990; 145:3054-61.
86. + cells through interaction with the κ light chains of IgE. J Immunol 2003; 170:1854-61.
87. Wills-Karp M, Luyimbazi J, Xueying X et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282:2258-61.
88. Grünig G, Warnock M, Wakil AE et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:2261-3.
89. Gruber BL, Baeza ML, Marchese MJ, Agnello V, Kaplan AP. Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J Invest Dermatol 1988; 90:213-7.
90. Grattan CEH, Francis DM, Hide M, Greaves MW. Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria. Clin Exp Allergy 1991; 21:695-704.
91. Hide M, Francis DM, Grattan CEH, Hakimi J, Kochan JP, Greaves MW. Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 1993; 328:1599-604.
92. Marone G, Casolaro V, Paganelli R, Quinti I. IgG Anti-IgE from atopic dermatitis induces mediator release from basophils and mast cells. J Invest Dermatol 1989; 93:246-52.
93. Gern JE, Busse WW. The role of viral infections in the natural history of asthma. J Allergy Clin Immunol 2000; 106:201-12.
94. Johnston SL. Bronchial hyperresponsiveness and cytokines in virus-induced asthma exacerbations. Clin Exp Allergy 1997; 27:7-9.
95. Holtzman MJ, Morton JD, Shornick LP et al. Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm. Physiol Rev 2002; 82:19-46.