Structural basis of the gp120 superantigen-binding site on human immunoglobulins

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6681-6688

  Karray, Saoussen ^a,d   Juompan, Laure ^a,e   Maroun, Rachid C ^a   Isenberg, David ^b   Silverman, Gregg J ^c   Zouali, Moncef ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 120; IMMUNOGLOBULIN;

ANTIGEN BINDING; ARTICLE; BINDING SITE; HUMAN; IMMUNOGLOBULIN STRUCTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES, ANTIBODY; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUPERANTIGENS;

EID: 0032534677     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Herman, A., J. W. Kappler, P. Marrack, and A. M. Pullen. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745.
2. Pascual, V., and J. D. Capra. 1991. Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Adv. Immunol. 49:1.
3. Zouali, M. 1995. B-cell superantigens: implications for selection of the human antibody repertoire. Immunol. Today 16:399.
4. Silverman, G. 1997. B-cell superantigens. Immunol. Today 18:379.
5. Sasso, E. H., G. J. Silverman, and M. Mannik. 1989. Human IgM molecules that bind staphylococcal protein A contain VHIII H chains. J. Immunol. 142:2778.
6. Sasano, M., D. R. Burton, and G. J. Silverman. 1993. Molecular selection of human antibodies with an unconventional bacterial B cell antigen. J. Immunol. 151:5822.
7. Kristiansen, S. V., V. Pascual, and P. E. Lipsky. 1994. Staphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes. J. Immunol. 153:2974.
8. Hakoda, M., N. Kamatani, K. S. Hayashimoto, G. J. Silverman, H. Yamanaka, C. Terai, and S. Kashiwazaki. 1996. Differential binding avidities of human IgM for staphylococcal protein A derive from specific germ-line VH3 gene usage. J. Immunol. 157:2976.
9. Inganas, M., S. G. Johansson, and J. Sjoquist. 1981. Further characterization of the alternative protein-A interaction of immunoglobulins: demonstration of an Fc-binding fragment of protein A expressing the alternative reactivity. Scand. J. Immunol. 14:379.
10. Deisenhofer, J. 1981. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9-and 2.8-A resolution. Biochemistry 20:2361.
11. Randen, I., K. N. Potter, Y. Li, K. M. Thompson, V. Pascual, O. Forre, J. B. Natvig, and J. D. Capra. 1993. Complementarity-determining region 2 is implicated in the binding of staphylococcal protein A to human immunoglobulin VHIII variable regions. Eur J. Immunol. 23:2682.
12. Hillson, J. L., N. S. Karr, I. R. Oppliger, M. Mannik, and E. H. Sasso. 1993. The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A. J. Exp. Med. 178:331.
13. Potter, K. N., Y. Li, and J. D. Capra. 1996. Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs. J. Immunol. 157:2982.
14. Berberian, L., L. Goodglick, T. J. Kipps, and J. Braun. 1993. Immunoglobulin VH3 gene products: natural ligands for HIV gp120. Science 261:1588.
15. Tomlinson, I. M., G. P. Cook, N. P. Carter, R. Elaswarapu, S. Smith, G. Walter, L. Buluwela, T. H. Rabbitts, and G. Winter. 1994. Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2. Hum. Mol. Genet. 3:853.
16. Zouali, M. 1994. Unravelling antibody genes. Nat. Genet. 7:118.
17. Brezinschek, H. P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155:190.
18. Berberian, L., J. Shukla, R. Jefferis, and J. Braun. 1994. Effects of HIV infection on VH3 (D12 idiotope) B cells in vivo. J. AIDS 7:641.
19. Juompan, L., P. Lambin, and M. Zouali. 1998. Selective deficit in antibodies specific for the superantigen binding site of gp120 in HIV infection. FASEB J. 14:1473.
20. Goodglick, L., N. Zevit, M. S. Neshat, and J. Braun. 1995. Mapping the Ig superantigen-binding site of HIV-1 gp120. J. Immunol. 155:5151.
21. Karray, S., and M. Zouali. 1997. Identification of the B-cell superantigen binding site of HIV-1 gp120. Proc. Natl. Acad. Sci. USA 94:1356.
22. Roben, P. W., A. N. Salem, and G. J. Silverman. 1995. VH3 family antibodies bind domain D of staphylococcal protein A. J. Immunol. 154:6437.
23. Lafaye, P., F. Nato, J. C. Mazie, and N. Doyen. 1996. Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab. Res. Immunol. 146:337.
24. Demaison, C., C. T. Ravirajan, D. A. Isenberg, and M. Zouali. 1995. Analysis of variable region genes encoding anti-Sm and anti-cardiolipin antibodies from a systemic lupus erythematosus patient. Immunology 86:487.
25. Ehrenstein, M. R., C. M. Longhurst, D. S. Latchman, and D. A. Isenberg. 1994. Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype. J. Clin. Invest. 93:1787.
26. Ravirajan, C. T., M. A. Rhaman, P. Lucienne, J. K. Kalsi, A. C. R. Martin, M. R. Ehrenstein, M. Griffiths, D. S. Latchman, and D. A. Isenberg. 1998. Genetic, structural and functional properties of a human IgG anti-DNA autoantibody. Eur. J. Immunol. 28:339.
27. Bensimon, C., P. Chastagner, and M. Zouali. 1994. Human lupus anti-DNA autoantibodies undergo essentially primary V κ gene rearrangements. EMBO J. 13:2951.
28. Chastagner, P., C. Demaison, J. Theze, and M. Zouali. 1994. Clonotypic dominance and variable gene elements of pathogenic anti-DNA autoantibodies from a single patient with lupus. Scand J. Immunol. 39:165.
29. Demaison, C., P. Chastagner, J. Theze, and M. Zouali. 1994. Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype. Proc. Natl. Acad. Sci. USA 91:514.
30. Rioux, J., M. Ohlin, C. Borrebaeck, and M. Newkirk. 1995. Molecular characterization of human monoclonal antibodies specific for the human cytomegalovirus: relationship of the variable region sequence to antigen specificity and rheumatoid factor-associated idiotype expression. Infect. Dis. 5:43.
31. Rioux, J. D., E. Zdarsky, M. M. Newkirk, and J. Rauch. 1995. Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: evidence for CDR2H mutations and CDR3H motifs. Mol. Immunol. 32:683.
32. Newkirk, M. M. 1992. Complete amino acid sequence of the variable regions of two highly related heavy and light chains of human IgG (SFL) and IgM (RIV) rheumatoid factors. Scand. J. Immunol. 35:651.
33. Kalsi, J. K., C. T. Ravirajan, W. H. Wiloch, F. Blanco, C. M. Longhurst, W. Williams, C. Chapman, J. Hillson, P. Youniou, D. Latchman, and D. A. Isenberg. 1995. Analysis of three new idiotypes on human monoclonal autoantibodies. Lupus 4:375.
34. Ohlin, M., V. A. Sundqvist, M. Mach, B. Wahren, and C. A. Borrebaeck. 1993. Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. J. Virol. 67:703.
35. Newkirk, M. M., R. A. Mageed, R. Jefferis, P. P. Chen, and J. D. Capra. 1987. Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments. J. Exp. Med. 166:550.
36. Ayala, A. M., J. Vazques, L. Danielsson, Fernandez de Cossio, M. E., and C. A. Borrebaeck. 1993. Sequence determination of variable region genes of two human monoclonal antibodies against Neisseria meningitidis. Gene 127:273.
37. Dersimonian, H., R. S. Schwartz, K. J. Barrett, and B. D. Stollar. 1987. Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies. J. Immunol. 139:2496.
38. Ohlin, M., H. Owman, J. D. Rioux, M. M. Newkirk, and C. A. Borrebaeck. 1994. Restricted variable region gene usage and possible rheumatoid factor relationship among human monoclonal antibodies specific for the AD-1 epitope on cytomegalovirus glycoprotein B. Mol. Immunol. 31:983.
39. Menon, S., M. A. Rahman, C. T. Ravirajan, D. Kandiah, C. M. Longhurst, T. McNally, W. M. Williams, D. S. Latchman, and D. A. Isenberg. 1997. The production, binding characteristics and sequence analysis of four human IgG monoclonal antiphospholipid antibodies. J. Autoimmunity 10:43.
40. Romagnani, S., M. G. Giudizi, P. G. del, E. Maggi, R. Biagiotti, F. Almerigogna, and M. Ricci. 1982. Demonstration on protein A of two distinct immunoglobulin-binding sites and their role in the mitogenic activity of Staphylococcus aureus Cowan I on human B cells. J. Immunol. 129:596.
41. Sasso, E. H., G. J. Silverman, and M. Mannik. 1991. Human IgA and IgG F(ab′ )2 that bind to staphylococcal protein A belong to the VHIII subgroup. J. Immunol. 147:1877.
42. Goodglick, L., J. Townsley-Fuchs, R. M. Fairhurst, M. Neshat, D. Marcelo, D. E. Mosier, and J. Braun. 1996. The HIV-1 gp120 superantigen: structural features and role in viral host pathogen interactions. In Human B Cell Superantigens. M. Zouali, ed. R. G. Landes Co., Austin, TX. p. 145.
43. Eggena, M., S. R. Targan, L. Iwanczyk, A. Vidrich, L. K. Gordon, and J. Braun. 1996. Phage display cloning and characterization of an immunogenetic marker (perinuclear anti-neutrophil cytoplasmic antibody) in ulcerative colitis. J. Immunol. 156:4005.
44. Kirkham, P. M., F. Mortari, J. A. Newton, and H. Schroeder Jr. 1992. Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding. EMBO J. 11:603.
45. Kabat, E. A., T. T. Wu, M. Reid-Miller, H. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest. United States Department of Health and Human Services, United States Government Printing Office, National Institutes of Health, Washington, DC.
46. Fan, Z. C., L. Shan, L. W. Guddat, X. M. He, W. R. Gray, R. L. Raison, and A. B. Edmundson. 1992. Three-dimensional structure of an Fv from a human IgM immunoglobulin. J. Mol. Biol. 228:188.
47. Silverman, G. J., R. Pirès, and J. Bouvet. 1996. An endogenous sialoprotein and a bacterial B-cell superantigen compete in their VH family specific binding interactions with human immunoglobulins. J. Immunol. 157:4496.
48. Sasso, E. H., J. H. Buckner, and L. A. Suzuki. 1995. Ethnic differences of polymorphism of an immunoglobulin VH3 gene. J. Clin. Invest. 96:1591.
49. Stewart, A., C. Huang, B. Stollar, and R. Schwartz. 1993. High-frequency representation of a single VH gene in the expressed human B cell repertoire. J. Exp. Med. 177:409.
50. Schroeder, H. J., and J. Y. Wang. 1990. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc. Natl. Acad. Sci. USA 87:6146.
51. Suzuki, I., L. Pfister, A. Glas, C. Nottenburg, and E. C. Milner. 1995. Representation of rearranged VH gene segments in the human adult antibody repertoire. J. Immunol. 154:3902.
52. Brezinschek, H. P., S. J. Foster, R. I. Brezinschek, T. Dorner, S. R. Domiati, and P. E. Lipsky. 1997. Analysis of the human VH gene repertoire: differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. J. Clin. Invest. 99:2488.
53. Kraj, P., S. P. Rao, A. M. Glas, R. R. Hardy, E. C. Milner, and L. E. Silberstein, 1997. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J. Immunol. 158:5824.
54. Liao, L., A. Marinescu, A. Molano, C. Ciurli, R. P. Sekaly, J. D. Fraser, A. Popowicz, and D. N. Posnett. 1996. TCR binding differs for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9). J. Exp. Med. 184:1471.
55. Hong, S. C., G. Waterbury, and C. J. Janeway. 1996. Different superantigens interact with distinct sites in the Vbeta domain of a single T cell receptor. J. Exp. Med. 183:1437.
56. Fields, B. A., E. L. Malchiodi, H. Li, X. Ysern, C. V. Stauffacher, P. M. Schlievert, K. Karjalainen, and R. A. Mariuzza. 1996. Crystal structure of a T-ceil receptor β-chain complexed with a superantigen. Nature 384:188.
57. Wyatt, R., P. D. Kwong, E. Desjardins, R. W. Sweet, J. Robinson, W. A. Hendrickson, and J. G. Sodroski. 1998. The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 393:705.
58. Kwong, P. D., R. Wyatt, J. Robinson, R. W. Sweet, J. G. Sodroski, and W. A. Hendrickson. 1998. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 and a neutralizing human antibody. Nature 393:648.
59. Chothia, C., A. M. Lesk, A. Tramontano, M. Levin, G. S. Smith, G. Air, S. Sheriff, E. A. Padlan, D. Davies, W. R. Tulip, P. M. Colman, S. Spinelli, P. M. Alzari, and R. Poljak. 1989. Conformations of immunoglobulin hypervariable regions. Nature 342:877.
60. Chothia, C., A. M. Lesk, E. Gherardi, I. M. Tomlinson, G. Walter, J. D. Marks, M. B. Llewelyn, and G. Winter. 1992. Structural repertoire of the human VH segments. J. Mol. Biol. 227:799.
61. H family-restricted staphylococcal B cell superantigen. J. Immunol. 161:5720.