Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 677-688

  Carrico, Dora ^a   Blaskovich, Michelle A ^b   Bucher, Cynthia J ^b   Sebti, Saïd M ^b   Hamilton, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Antitumor agents; Farnesyltransferase; Geranylgeranyltransferase I; Peptidomimetics

Indexed keywords

1 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO]CYCLOHEXANECARBOXYLIC ACID; 1 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER; 2 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO] 3 PHENYLPROPIONIC ACID; 2 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO] 3 PHENYLPROPIONIC ACID METHYL ESTER; 2 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO] 4 METHYLPENTANOIC ACID; 2 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO] 4 METHYLPENTANOIC ACID METHYL ESTER; 2 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO] 4 METHYLSULFANYLBUTYRIC ACID; 2 [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO] 4 METHYLSULFANYLBUTYRIC ACID METHYL ESTER; 2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL] N (3 METHYLBUTYL)ACETAMIDE; [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO]ACETIC ACID; [2 [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETYLAMINO]ACETIC ACID METHYL ESTER; [3 (1H IMIDAZOL 4 YLMETHYL) 2,4 DIOXO 3,4 DIHYDRO 2H QUINAZOLIN 1 YL]ACETIC ACID BENZYL ESTER; ANTINEOPLASTIC AGENT; DIPEPTIDE; PHENYLALANINE; PROTEIN FARNESYLTRANSFERASE; TRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE;

ALKYL AND ARYL TRANSFERASES; ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; UREA;

MAMMALIA;

EID: 11844262631     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.053     Document Type: Article

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