How heterologously expressed Escherichia coli genes contribute to understanding DNA repair processes in Saccharomyces cerevisiae

Current Genetics

Volumn 46, Issue 6, 2004, Pages 317-330

  Brozmanová, Jela ^a   Vlčková, Viera ^b   Chovanec, Miroslav ^a  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b Faculty of Natural Sciences   (Slovakia)

Author keywords

DNA repair; Escherichia coli; Heterologous expression; Saccharomyces cerevisiae

Indexed keywords

BACTERIAL DNA; CELL DNA; ENDONUCLEASE; ESCHERICHIA COLI PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD51 PROTEIN; RAD52 PROTEIN; RECA PROTEIN;

CELL MUTANT; CELL VIABILITY; DNA ALKYLATION; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENETIC CODE; GENETIC CONSERVATION; GENETIC DIFFERENCE; GENETIC SIMILARITY; GENETIC TRAIT; GENOMIC INSTABILITY; HETEROLOGOUS EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECA GENE; REVIEW; SACCHAROMYCES CEREVISIAE;

CELL SURVIVAL; DNA REPAIR; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VARIATION (GENETICS);

ADA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 11244294919     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-004-0536-2     Document Type: Review

References (134)

1. Aas PA, Otterlei M, Falnes PO, Vagbo CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421:859-863. 10.1038/nature01363, 1:CAS:528:DC%2BD3sXht1Kqt74%3D, 12594517
2. Aboussekhra A, Chanet R, Adjiri A, Fabre F (1992) Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol Cell Biol 12:3224-3234. 1:CAS:528:DyaK3sXit1Kqs7w%3D, 1620127
3. Alseth I, Eide L, Pirovano M, Rognes T, Seeberg E, Bjørå M (1999) The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli , Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol Cell Biol 19:3779-3787. 1:CAS:528:DyaK1MXislSks7s%3D, 10207101
4. Asahara H, Wistort PM, Bank JF, Bakerian RH, Cunningham RP (1989) Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene. Biochemistry 28:4444-4449. 1:CAS:528:DyaL1MXitVyhsbk%3D, 2669955
5. Augeri L, Lee YM, Barton AB, Doetsch PW (1997) Purification, characterization, gene cloning, and expression of Saccharomyces cerevisiae redoxyendonuclease, a homolog of Escherichia coli endonuclease III. Biochemistry 36:721-729. 10.1021/bi9625511, 1:CAS:528:DyaK2sXis1arsA%3D%3D, 9020769
6. Aylon Y, Kupiec M (2004) New insights into the mechanism of homologous recombination in yeast. Mutat Res 566:231-248. 1:CAS:528:DC%2BD2cXjtVCnsL4%3D, 15082239
7. Bailly V, Verly WG (1987) Escherichia coli endonuclease III is not an endonuclease but a beta-elimination catalyst. Biochem J 242:565-572. 1:CAS:528:DyaL2sXhtlChs7s%3D, 2439070
8. Basile G, Aker M, Mortimer RK (1992) Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51 . Mol Cell Biol 12:3235-3246. 1:CAS:528:DyaK3sXit1Kqs70%3D, 1620128
9. Baumann P, West SC (1998) Role of the human RAD51 protein in homologous recombination and double-stranded-break repair. Trends Biochem Sci 23:247-251. 10.1016/S0968-0004(98)01232-8, 1:CAS:528:DyaK1cXkvFClsbo%3D, 9697414
10. Beranek DT, Weis CC, Swenson DH (1980) A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography. Carcinogenesis 1:595-606. 1:CAS:528:DyaL3cXmtFKgu70%3D, 11219835
11. Bi B, Rybalchenko N, Golub EI, Radding CM (2004) Human and yeast Rad52 proteins promote DNA strand exchange. Proc Natl Acad Sci USA 101:9568-9572. 10.1073/pnas.0403205101, 1:CAS:528:DC%2BD2cXlvVahsL4%3D, 15205482
12. Bianco PR, Tracy RB, Kowalczykowski SC (1998) DNA strand exchange proteins: A biochemical and physical comparison. Front Biosci 3:D570-D603. 1:CAS:528:DyaK1cXlvVWjsbw%3D, 9632377
13. Boiteux S (1993) Properties and biological functions of the NTH and FPG proteins of Escherichia coli : Two DNA glycosylases that repair oxidative damage in DNA. J Photochem Photobiol B 19:87-96. 10.1016/1011-1344(93)87101-R, 1:CAS:528:DyaK3sXlslKgsLs%3D, 8377077
14. Breimer LH, Lindahl T (1984) DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coli . J Biol Chem 259:5543-5548. 1:CAS:528:DyaL2cXktlCqtLs%3D, 6371006
15. Brendel M, Grey M, Maris AF, Hietkamp J, Fesus Z, Pich CT, Dafre AL, Schmidt M, Eckardt-Schupp F, Henriques JA (1998) Low glutathione pools in the original pso3 mutant of Saccharomyces cerevisiae are responsible for its pleiotropic sensitivity phenotype. Curr Genet 33:4-9. 10.1007/s002940050301, 1:CAS:528:DyaK1cXhtVWitrY%3D, 9472073
16. Brendel M, Henriques JA (2001) The pso mutants of Saccharomyces cerevisiae comprise two groups: One deficient in DNA repair and another with altered mutagen metabolism. Mutat Res 489:79-96. 1:CAS:528:DC%2BD3MXnslajt7w%3D, 11673090
17. Brendel M, Bonatto D, Strauss M, Revers LF, Pungartnik C, Saffi J, Henriques JA (2003) Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae . Mutat Res 544:179-193. 1:CAS:528:DC%2BD3sXptlyltr0%3D, 14644320
18. Brennand J, Margison GP (1986) Reduction of the toxicity and mutagenicity of alkyklation agents in mammalian cells harbouring the E. coli alkyltransferase gene. Proc Natl Acad Sci USA 83:6292-6296. 1:CAS:528:DyaL28XlsVOqt7k%3D, 3529080
19. Brozmanová J, Kleibl K, Vlčková V, Škorvaga M, Černáková L, Margison GP (1990) Expression of the E. coli ada gene in yeast protects against the toxic and mutagenic effects of N -methyl- N′-nitro- N -nitrosoguanidine. Nucleic Acids Res 18:331-335. 2183180
20. Brozmanová J, Černáková L, Vlčková V, Duraj J, Fridrichová I (1991) The Escherichia coli recA gene increases resistance of the yeast Saccharomyces cerevisiae to ionizing and ultraviolet radiation. Mol Gen Genet 227:473-480. 10.1007/BF00273940, 1865881
21. Brozmanová J, Vlčková V, Chovanec M, Černáková L, Škorvaga M, Margison GP (1994) Expression of the E. coli ada gene in S. cerevisiae provides cellular resistance to N -methyl- N′-nitro- N -nitrosoguanidine in rad6 but not in rad52 mutants. Nucleic Acids Res 22:5717-5722. 7838727
22. Brozmanová J, Dudáš A, Henriques JA (2001a) Repair of oxidative DNA damage-an important factor reducing cancer risk. Neoplasma 48:85-93. 11478699
23. Brozmanová J, Vlčková V, Farkašová E, Dudáš A, Vlasáková D, Chovanec M, Mikulovská Ž, Fridrichová I, Saffi J, Henriques JA (2001b) Increased DNA double strand breakage is responsible for sensitivity of the pso3-1 mutant of Saccharomyces cerevisiae to hydrogen peroxide. Mutat Res 485:345-355. 11585367
24. Bruner SD, Nash HM, Lane WS, Verdine GL (1998) Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway. Curr Biol 8:393-403. 10.1016/S0960-9822(98)70158-7, 1:CAS:528:DyaK1cXitFyitrw%3D, 9545197
25. Burgess S, Jaruga P, Dodson ML, Dizdaroglu M, Lloyd RS (2002) Determination of active site residues in Escherichia coli endonuclease VIII. J Biol Chem 277:2938-2944. 10.1074/jbc.M110499200, 1:CAS:528:DC%2BD38XhtVSgtL0%3D, 11711552
26. Camerini-Otero RD, Hsieh P (1995) Homologous recombination proteins in prokaryotes and eukaryotes. Annu Rev Genet 29:509-552. 10.1146/annurev.genet.29.1.509, 1:CAS:528:DyaK28XlsFyg, 8825485
27. Chenevert JA, Naumovski L, Schultz RA, Friedberg EC (1986) Partial complementation of the UV sensitivity of E. coli and yeast excision repair mutants by the cloned denV gene of bacteriophage T4. Mol Gen Genet 203:163-171. 1:CAS:528:DyaL28XktF2ls7o%3D, 3520242
28. Cheng SC, Tarn WY, Tsao TY, Abelson J (1993) PRP19: A novel spliceosomal component. Mol Cell Biol 13:1876-1882. 1:CAS:528:DyaK3sXit1Oitrw%3D, 8441419
29. Clark AJ, Margulies AD (1965) Isolation and characterization of recombination-deficient mutants of Escherichia coli K12. Proc Natl Acad Sci USA 53:451-459. 1:STN:280:CCqD1MfmslM%3D, 14294081
30. Clarke ND, Kvaal M, Seeberg E (1984) Cloning of Escherichia coli genes encoding 3-methyladenine DNA glycosylases I and II. Mol Gen Genet 197:368-372. 1:CAS:528:DyaL2MXktVWmsrg%3D, 6098799
31. Cooper AJ, Waters R (1987) A complex pattern of sensitivity to simple monofunctional alkylating agents exists amongst the rad mutants of Saccharomyces cerevisiae . Mol Gen Genet 209:142-148. 1:CAS:528:DyaL2sXltlSksLg%3D, 3312952
32. Cunningham RP, Weiss B (1985) Endonuclease III ( nth ) mutants of Escherichia coli . Proc Natl Acad Sci USA 82:474-478. 1:CAS:528:DyaL2MXhtVOhtbo%3D, 2982160
33. Cunningham RP, Asahara H, Bank JF, Scholes CP, Salerno JC, Surerus K, Munck E, McCracken J, Peisach J, Emptage MH (1989) Endonuclease III is an iron-sulfur protein. Biochemistry 28:4450-4455. 1:CAS:528:DyaL1MXitVyntr4%3D, 2548577
34. Cunningham RP, Ahern H, Xing D, Thayer MM, Tainer JA (1994) Structure and function of Escherichia coli endonuclease III. Ann NY Acad Sci 726:215-222. 1:CAS:528:DyaK2MXhvVOksLk%3D, 8092678
35. Černáková L, Fridrichová I, Piršel M, Kleibl K, Duraj J, Brozmanová J (1991) Expression of the Escherichia coli recA gene in the yeast Saccharomyces cerevisiae . Biochimie 73:285-288. 10.1016/0300-9084(91)90215-M, 1883887
36. de Andrade HH, Marques EK, Schenberg AC, Henriques JA (1989) The PSO4 gene is responsible for an error-prone recombinational DNA repair pathway in Saccharomyces cerevisiae . Mol Gen Genet 217:419-426. 2671661
37. Demple B, Linn S (1980) DNA N-glycosylases and UV repair. Nature 287:203-208. 1:CAS:528:DyaL3MXmtVGiug%3D%3D, 6253795
38. Demple B, Harrison L (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 63:915-948. 10.1146/annurev.bi.63.070194.004411, 1:CAS:528:DyaK2MXitlCgtA%3D%3D, 7979257
39. Dizdaroglu M (2003) Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage. Mutat Res 531:109-126. 1:CAS:528:DC%2BD3sXpt1ert70%3D, 14637249
40. Doetsch PW, Morey NJ, Swanson RL, Jinks-Robertson S (2001) Yeast base excision repair: Interconnections and networks. Prog Nucleic Acid Res Mol Biol 68:29-39. 1:CAS:528:DC%2BD3MXntFGlurY%3D, 11554305
41. Dudáš A, Marková E, Vlasóková D, Kolman A, Bartošová Z, Brozmanová J, Chovanec M (2003) The Escherichia coli RecA protein complements recombination defective phenotype of the Saccharomyces cerevisiae rad52 mutant cells. Yeast 20:389-396. 10.1002/yea.971, 12673622
42. Dudáš A, Chovanec M (2004) DNA double-strand break repair by homologous recombination. Mutat Res 566:131-167. 15164978
43. Eide L, Bjørås M, Pirovano M, Alseth I, Berdal KG, Seeberg E (1996) Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli . Proc Natl Acad Sci USA 93:10735-10740. 10.1073/pnas.93.20.10735, 1:CAS:528:DyaK28XmtVOltLo%3D, 8855249
44. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (2002) DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). J Cell Sci 115:207-216. 1:CAS:528:DC%2BD38XovVehsA%3D%3D, 11801738
45. Falnes PO, Johansen RF, Seeberg E (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli . Nature 419:178-182. 10.1038/nature01048, 1:CAS:528:DC%2BD38XmvV2qtr4%3D, 12226668
46. Farkašová E, Chovanec M, Vlasáková D, Vlčková V, Margison GP, Brozmanová J (2000) Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents. Environ Mol Mutagen 35:66-69. 10.1002/(SICI)1098-2280(2000)35:1<66::AID-EM9>3.3.CO;2-U, 10692229
47. Fridrichová I, Kovařík A, Rosskopfová O (1992) Immunological quantification of RecA protein in cell extracts of E. coli after exposure to chemical mutagens or UV radiation. Folia Microbiol 37:24-30
48. Friedberg EC (1988) Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae . Microbiol Rev 52:70-102. 1:CAS:528:DyaL1cXhs1ahtL0%3D, 3280967
49. Friedberg EC (1991) Eukaryotic DNA repair: Glimpses through the yeast Saccharomyces cerevisiae . Bioessays 13:91-95. 1:CAS:528:DyaL1cXhs1ahtL0%3D, 3280967
50. Friedberg EC, Siede W, Cooper AJ (1992) Cellular responses to DNA damage in yeast. In: Broach JR (ed) The molecular and cellular biology of the yeast Saccharomyces : Genome dynamics, protein synthesis, and energetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp 147-192
51. Friedberg EC (2000) Biological responses to DNA damage: A perspective in the new millennium. Cold Spring Harb Symp Quant Biol 65:593-602. 1:CAS:528:DC%2BD3MXlt1Olsb4%3D, 12760078
52. Game JC (2000) The Saccharomyces repair genes at the end of the century. Mutat Res 451:277-293. 1:CAS:528:DC%2BD3cXltVGrtbc%3D, 10915878
53. Girard PM, Boiteux S (1997) Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae . Biochimie 79:559-566. 10.1016/S0300-9084(97)82004-4, 1:CAS:528:DyaK1cXmtFeqsQ%3D%3D, 9466693
54. Gossett J, Lee K, Cunningham RP, Doetsch PW (1988) Yeast redoxyendonuclease, a DNA repair enzyme similar to Escherichia coli endonuclease III. Biochemistry 27:2629-2634. 1:CAS:528:DyaL1cXhsVGqt7o%3D, 2454659
55. Goth-Goldstein R, Johnson PL (1990) Repair of alkylation damage in Saccharomyces cerevisiae . Mol Gen Genet 221:353-357. 10.1007/BF00259399, 1:CAS:528:DyaK3cXkslClurg%3D, 2199817
56. Gotzmann J, Gerner C, Meissner M, Holzmann K, Grimm R, Mikulitz W, Sauermann G (2000) hNMP 200: A novel human common nuclear matrix protein combining structural and regulatory functions. Exp Cell Res 261:166-179. 10.1006/excr.2000.5025, 1:CAS:528:DC%2BD3cXotVyntrk%3D, 11082287
57. Grey M, Dusterhoft A, Henriques JA, Brendel M (1996) Allelism of PSO4 and PRP19 links pre-mRNA processing with recombination and error-prone DNA repair in Saccharomyces cerevisiae . Nucleic Acids Res 24:4009-4014. 10.1093/nar/24.20.4009, 1:CAS:528:DyaK28XmvVKitbY%3D, 8918805
58. Gros L, Saparbaev MK, Laval J (2002) Enzymology of the repair of free radicals-induced DNA damage. Oncogene 21:8905-8925. 10.1038/sj.onc.1206005, 1:CAS:528:DC%2BD38XpsFShu7k%3D, 12483508
59. Harrison L, Škorvaga M, Cunningham RP, Hendry JH, Margison GP (1992) Transfection of the Escherichia coli nth gene into radiosensitive Chinese hamster cells: Effects on sensitivity to radiation, hydrogen peroxide and bleomycine sulfate. Radiat Res 132: 30-39. 1:CAS:528:DyaK38XmsVOrsr8%3D, 1384080
60. Hays SL, Firmenich AA, Berg P (1995) Complex formation in yeast double-strand break repair: Participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc Natl Acad Sci USA 92:6925-6929. 1:CAS:528:DyaK2MXntVSktrg%3D, 7624345
61. Henriques JA, Vicente EJ, Leandro da Silva KV, Schenberg AC (1989) PSO4 : A novel gene involved in error-prone repair in Saccharomyces cerevisiae . Mutat Res 218:111-124. 1:CAS:528:DyaL1MXmt1yrsro%3D, 2671705
62. Henriques JA, Brendel M (1990) The role of PSO and SNM genes in DNA repair of the yeast Saccharomyces cerevisiae . Curr Genet 18:387-393. 1:CAS:528:DyaK3MXhvVWkt74%3D, 2078865
63. Henriques JA, Brozmanová J, Brendel M (1997) Role of PSO genes in the repair of photoinduced interstrand cross-links and photooxidative damage in the DNA of the yeast Saccharomyces cerevisiae . J Photochem Photobiol B 39:185-196. 10.1016/S1011-1344(97)00020-1, 1:CAS:528:DyaK2sXksFeiu7o%3D, 9253198
64. Hoeijmakers JH (2001) Genome maintenance mechanisms for preventing cancer. Nature 411:366-374. 10.1038/35077232, 1:CAS:528:DC%2BD3MXktVSjs74%3D
65. Jazayeri A, Jackson SP (2002) Screening the yeast genome for new DNA-repair genes. Genome Biol 3:1009. 10.1186/gb-2002-3-4-reviews1009
66. iang D, Hatahet Z, Melamede RJ, Kow YW, Wallace SS (1997) Characterization of Escherichia coli endonuclease VIII. J Biol Chem 272:32230-32239. 10.1074/jbc.272.51.32230, 1:CAS:528:DyaK1cXis1Kltw%3D%3D, 9405426
67. Jimenez-Sanchez A, Cerda-Olmedo E (1975) Mutation and DNA replication in Escherichia coli treated with low concentrations of N -methyl- N′-nitro- N -nitrosoguanidine. Mutat Res 28:337-345. 1:CAS:528:DyaE2MXkvFWmtrY%3D, 1094280
68. Karlin S, Brocchieri L (1996) Evolutionary conservation of recA genes in relation to protein structure and function. J Bacteriol 178:1881-1894. 1:CAS:528:DyaK28XhvFOksLY%3D, 8606161
69. Kat A, Thilly WG, Fang WH, Longley MJ, Li GM, Modrich P (1993) An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci USA 90:6424-6428. 1:CAS:528:DyaK3sXlvFGhs74%3D, 8341649
70. Katcher HL, Wallace SS (1983) Characterization of the Escherichia coli X-ray endonuclease, endonuclease III. Biochemistry 22:4071-4081. 1:CAS:528:DyaL3sXks1Knsr4%3D, 6351916
71. Kido M, Yoneda Y, Nakanishi M, Uchida T, Okada Y (1992) Escherichia coli RecA protein modified with a nuclear location signal binds to chromosomes in living mammalian cells. Exp Cell Res 198:107-114. 1:CAS:528:DyaK38Xltlyhtw%3D%3D, 1727044
72. 6 -methylguanine DNA-methyltransferase in other organisms. Mutat Res 512:67-84. 1:CAS:528:DC%2BD38XmvVCrt74%3D, 12220590
73. Kow YW, Wallace SS (1987) Mechanism of action of Escherichia coli endonuclease III. Biochemistry 26:8200-8206. 1:CAS:528:DyaL1cXisF2i, 3327518
74. Kowalczykowski SC, Dixon DA, Eggleston AK, Lauder SD, Rehrauer WM (1994) Biochemistry of homologous recombination in Escherichia coli . Microbiol Rev 58:401-465. 1:CAS:528:DyaK2cXmsFSlu70%3D, 7968921
75. Krejči L, Damborsky J, Thomsen B, Duno M, Bendixen C (2001) Molecular dissection of interactions between Rad51 and members of the recombination-repair group. Mol Cell Biol 21:966-976. 10.1128/MCB.21.3.966-976.2001, 1:CAS:528:DC%2BD3MXmtVOrug%3D%3D, 11154282
76. Langeveld SA, Yasui A, Eker APM (1985) Expression of an Escherichia coli phr gene in the yeast Saccharomyces cerevisiae . Mol Gen Genet 199: 396-400. 1:CAS:528:DyaL2MXks1Kjsbc%3D, 2993790
77. Lindahl T, Sedgwick B, Sekiguchi M, Nakabeppu Y (1988) Regulation and expression of the adaptive response to alkylating agents. Annu Rev Biochem 57:133-157. 10.1146/annurev.bi.57.070188.001025, 1:CAS:528:DyaL1cXks1yht7k%3D, 3052269
78. Little JW, Edmiston SH, Pacelli LZ, Mount DW (1980) Cleavage of the Escherichia coli LexA protein by the RecA protease. Proc Natl Acad Sci USA 77:3225-3229. 1:CAS:528:DyaL3cXkvFWlurg%3D, 6447873
79. Maga JA, McEntee K (1985) Response of S. cerevisiae to N -methyl- N′-nitro- N -nitrosoguanidine: Mutagenesis, survival and DDR gene expression. Mol Gen Genet 200:313-321. 1:CAS:528:DyaL2MXltlKrtLw%3D, 3929020
80. Mahajan KN, Mitchell BS (2003) Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci USA 100:10746-10751. 10.1073/pnas.1631060100, 1:CAS:528:DC%2BD3sXnslyntr8%3D, 12960389
81. Melamede RJ, Hatahet Z, Kow YW, Ide H, Wallace SS (1994) Isolation and characterization of endonuclease VIII from Escherichia coli . Biochemistry 33:1255-1264. 1:CAS:528:DyaK2cXhsFOiurc%3D, 8110759
82. Memisoglu A, Samson L (1996) DNA repair functions in heterologous cells. Crit Rev Biochem Mol Biol 31:405-447. 1:CAS:528:DyaK2sXls12ltw%3D%3D, 8994804
83. Memisoglu A, Samson L (2000) Base excision repair in yeast and mammals. Mutat Res 451:39-51. 1:CAS:528:DC%2BD3cXltVGrtLs%3D, 10915864
84. Morais MA, Brozmanová J, Benfato MS, Duraj J, Vlčková V, Henriques JA (1994) The E. coli recA gene can restore the defect in mutagenesis of the pso4 - 1 mutant of S. cerevisiae . Mutat Res 314:209-220. 1:CAS:528:DyaK2cXktVansL0%3D, 7513054
85. Morais MA, Vicente EJ, Brozmanová J, Schenberg AC, Henriques JA (1996) Further characterization of the yeast pso4 - 1 mutant: interaction with rad51 and rad52 mutants after photoinduced psoralen lesions. Curr Genet 29:211-218. 10.1007/s002940050038, 8595666
86. Morais MA, Vlčková V, Fridrichová I, Slaninová M, Brozmanová J (1998) Effect of bacterial recA expression on DNA repair in the rad51 and rad52 mutants of Saccharomyces cerevisiae . Genet Mol Biol 21:3-9. 1:CAS:528:DyaK1cXjsVyltr8%3D
87. Ogawa T, Wabiko H, Tsurimoto T, Horii T, Masukata H, Ogawa H (1979) Characteristics of purified RecA protein and the regulation of its synthesis in vivo. Cold Spring Harb Symp Quant Biol 43:909-. 1:CAS:528:DyaE1MXlsFCis7k%3D, 158476915
88. Polakowska R, Perozzi G, Prakash L (1986) Alkylation mutagenesis in Saccharomyces cerevisiae : Lack of evidence for an adaptive response. Curr Genet 10:647-655. 1:CAS:528:DyaL28XkslCiu74%3D, 3329040
89. 6 -alkylguanine-DNA-alkyltransferase gene of E. coli . Nucleic Acids Res 15:9177-9193. 1:CAS:528:DyaL1cXhsVCgs70%3D, 2825131
90. Radman M (1976) An endonuclease from Escherichia coli that introduces single polynucleotide chain scissions in ultraviolet-irradiated DNA. J Biol Chem 251:1438-1445. 1:CAS:528:DyaE28XhtFOmtLg%3D, 3498
91. Reiss B, Klemm M, Kosak H, Schell J (1996) RecA protein stimulates homologous recombination in plants. Proc Natl Acad Sci USA 93:3094-3098. 10.1073/pnas.93.7.3094, 1:CAS:528:DyaK28XitVCiu7w%3D, 8610174
92. Reiss B, Kosak H, Klemm M, Schell J (1997) Targeting of a functional Escherichia coli RecA protein to the nucleus of plant cells. Mol Gen Genet 253:695-702. 10.1007/s004380050373, 1:CAS:528:DyaK2sXisV2hu7c%3D, 9079880
93. Reiss B, Schubert I, Kopchen K, Wendeler E, Schell J, Puchta H (2000) RecA stimulates sister chromatid exchange and the fidelity of double-strand break repair, but not gene targeting, in plants transformed by Agrobacterium . Proc Natl Acad Sci USA 97:3358-3363. 10.1073/pnas.050582797, 1:CAS:528:DC%2BD3cXitlWqtr8%3D, 10725370
94. Resnick MA, Cox BS (2000) Yeast as an honorary mammal. Mutat Res 451:1-11. 1:CAS:528:DC%2BD3cXltVGrtLw%3D, 10915861
95. Revers LF, Cardone JM, Bonatto D, Saffi J, Grey M, Feldmann H, Brendel M, Henriques JA (2002) Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4 - 1 . Nucleic Acids Res 30:4993-5003. 10.1093/nar/gkf632, 1:CAS:528:DC%2BD38XoslOisLo%3D, 12434004
96. Roberts JW, Roberts CW, Craig NL, Phizicky EM (1979) Activity of the Escherichia coli recA -gene product. Cold Spring Harb Symp Quant Biol 43:917-920. 1:CAS:528:DyaE1MXlsFChsrs%3D, 158477
97. Roca AI, Cox MM (1997) RecA protein: Structure, function, and role in recombinational DNA repair. Prog Nucleic Acid Res Mol Biol 56:129-223. 1:CAS:528:DyaK2sXivVGmsbc%3D, 9187054
98. Roche H, Gietz RD, Kunz BA (1993) Specificities of the Saccharomyces cerevisiae rad6 , rad18 , and rad52 mutators exhibit different degrees of dependance on the REV3 gene product, a putative nonessential DNA polymerase. Genetics 140:443-456
99. Saffhill R, Margison GP, O'Connor PJ (1985) Mechanisms of carcinogenesis induced by alkylating agents. Biochim Biophys Acta 823:111-145. 10.1016/0304-419X(85)90009-5, 1:CAS:528:DyaL28Xhs1Wgsg%3D%3D, 3907708
100. Saito Y, Uraki F, Nakajima S, Asaeda A, Ono K, Kubo K, Yamamoto K (1997) Characterization of endonuclease III ( nth ) and endonuclease VIII ( nei ) mutants of Escherichia coli K-12. J Bacteriol 179:3783-3785. 1:CAS:528:DyaK2sXjsF2mtLY%3D, 9171430
101. Samson L, Cairns J (1977) A new pathway for DNA repair in Escherichia coli . Nature 267:281-283. 1:CAS:528:DyaE2sXlt1yjs7Y%3D, 325420
102. Samson LD (1992) The repair of DNA alkylation damage by methyltransferases and glycosylases. Essays Biochem 27:69-78. 1:CAS:528:DyaK3sXltlagtrg%3D, 1425604
103. Samson L, Derfler B, Waldstein EA (1986) Suppression of human DNA alkylation DNA repair defects by Escherichia coli DNA-repair genes. Proc Natl Acad Sci USA 83: 5607-5610. 1:CAS:528:DyaL28XlsVOhsL8%3D, 3526337
104. 6 -methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae . J Biol Chem 265:20-25. 1:CAS:528:DyaK3cXjt1Clsg%3D%3D, 2403555
105. 4 -methylthymine repair by eukaryotic methyltransferases. J Biol Chem 266:2767-2771. 1:CAS:528:DyaK3MXhtFOmtLg%3D, 1993655
106. Sedgwick B, Robins P, Totty N, Lindahl T (1988) Functional domains and methyl acceptor sites of the Escherichia coli Ada protein. J Biol Chem 263:4430-4433. 1:CAS:528:DyaL1cXhs1emt7o%3D, 3162236
107. Shcherbakova OG, Lanzov VA, Ogawa H, Filatov MV (2000) Overexpression of bacterial RecA protein stimulates homologous recombination in somatic mammalian cells. Mutat Res 459:65-71. 1:CAS:528:DC%2BD3cXhtFaksL4%3D, 10677684
108. Shinagawa H, Iwasaki H, Kato T, Nakata A (1988) RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proc Natl Acad Sci USA 85:1806-1810. 1:CAS:528:DyaL1cXktlaqs78%3D, 3126496
109. Shinohara A, Ogawa A, Ogawa T (1992) Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69:457-470. 10.1016/0092-8674(92)90447-K, 1:CAS:528:DyaK3sXitVKgurk%3D, 1581961
110. Shinohara A, Ogawa H, Matsuda Y, Ushio N, Ikeo K, Ogawa T (1993) Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA . Nat Genet 4:239-243. 10.1038/ng0793-239, 1:CAS:528:DyaK3sXms1eksbs%3D, 8358431
111. Singer B (1975) The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis. Prog Nucleic Acid Res Mol Biol 15:219-284. 1:CAS:528:DyaE2MXkslamt78%3D, 237307
112. Slaninová M, Vlčková V, Brozmanová J, Morais MA, Henriques JA (1996) Biological consequences of E. coli RecA protein expression in the repair defective pso4 - 1 and rad51::URA3 mutants of S. cerevisiae after treatment with N -methyl- N'-nitro- N -nitrosoguanidine. Neoplasma 43:315-319. 8996551
113. Sung P (1994) Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast Rad51 protein. Science 265:1241-1243. 1:CAS:528:DyaK2cXmt1emsr8%3D, 8066464
114. Sung P, Robberson DL (1995) DNA strand exchange mediated by a Rad51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Cell 82:453-461. 10.1016/0092-8674(95)90434-4, 1:CAS:528:DyaK2MXnsFSgtr0%3D, 7634335
115. Sutton MD, Narumi I, Walker GC (2002) Posttranslational modification of the umuD -encoded subunit of Escherichia coli DNA polymerase V regulates its interactions with the beta processivity clamp. Proc Natl Acad Sci USA 99:5307-5312. 10.1073/pnas.082322099, 1:CAS:528:DC%2BD38XjtFKls74%3D, 11959982
116. Swanson RL, Morey NJ, Doetsch PW, Jinks-Robertson S (1999) Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae . Mol Cell Biol 19:2929-2935. 1:CAS:528:DyaK1MXit1als7g%3D, 10082560
117. Symington LS (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66:630-670
118. Škorvaga M, Černaková L, Chovanec M, Vlasáková D, Kleibl K, Hendry JH, Margison GP, Brozmanová J (2003) Effect of expression of the Escherichia coli nth gene in Saccharomyces cerevisiae on the toxicity of ionizing radiation and hydrogen peroxide. Int J Radiat Biol 79:747-755. 10.1080/09553000310001606849, 14703947
119. Thayer MM, Ahern H, Xing D, Cunningham RP, Tainer JA (1995) Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J 14:4108-4120. 1:CAS:528:DyaK2MXnvVekt7o%3D, 7664751
120. Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419:174-178. 10.1038/nature00908, 1:CAS:528:DC%2BD38XmvV2qsrk%3D, 12226667
121. Valerie K, Fronko G, Henderson EE, Riel JK (1986) Expresion of the denV gene of coliphage T4 in UV sensitive rad mutants of Saccharomyces cerevisiae . Mol Cell Biol 6:3559-3562. 1:CAS:528:DyaL28XlvVGjsb4%3D, 3540595
122. Valerie K, Green AP, Riel JK, Henderson EE (1987) Transient and stable complementation of ultraviolet repair in XP cells by the denV gene of bacteriophage T4. Cancer Res 47:2967-2971. 1:CAS:528:DyaL2sXksFeitrk%3D, 3567913
123. van den Bosch M, Lohman PH, Pastink A (2002) DNA double-strand break repair by homologous recombination. Biol Chem 383:873-892. 12222678
124. Vlčková V, Černáková L, Farkašová E, Brozmanová J (1994) The Escherichia coli recA gene increases UV-induced mitotic gene conversion in Saccharomyces cerevisiae . Curr Genet 25:47-474. 8082195
125. Vlčková V, Slaninová M, Morais MA, Henriques JA, Fridrichová I, Brozmanová J (1997) Searching for a functional analogy between yeast Pso4 and bacterial RecA proteins in induced mitotic recombination. Neoplasma 44:374-379. 9605011
126. Walker GC (1984) Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli . Microbiol Rev 48:60-93. 1:CAS:528:DyaL2cXhslWhsL4%3D, 6371470
127. Wallace SS (1998) Enzymatic processing of radiation-induced free radical damage in DNA. Radiat Res 150:S60-S79. 1:CAS:528:DyaK1cXnt1Cqsro%3D, 9806610
128. Wallace SS, Bandaru V, Kathe SD, Bond JP (2003) The enigma of endonuclease VIII. DNA Repair 2:441-453. 10.1016/S1568-7864(02)00182-9, 1:CAS:528:DC%2BD3sXjtFWhsbs%3D, 12713806
129. Ward JF (1981) Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiat Res 86:185-195. 1:CAS:528:DyaL3MXitVCmtL8%3D, 7015409
130. Ward JF (1985) Biochemistry of DNA lesions. Radiat Res [Suppl] 8:S103-S111. 1:STN:280:BimC387mtVU%3D
131. 4 -methylthymine DNA repair methyltransferase gene. EMBO J 10:2179-2186. 1:CAS:528:DyaK38XhsVGisLc%3D, 2065659
132. Xiao W, Samson L (1992) The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: Its promoter and entire coding sequence, regulation and in vivo biological functions. Nucleic Acids Res 20:3599-3606. 1:CAS:528:DyaK3sXkt1WksLc%3D, 1641326
133. You HJ, Swanson RL, Doetsch PW (1998) Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III. Biochemistry 37:6033-6040. 10.1021/bi973042h, 1:CAS:528:DyaK1cXislGhur8%3D, 9558341
134. You HJ, Swanson RL, Harrington C, Corbett AH, Jinks-Robertson S, Senturker S, Wallace SS, Boiteux S, Dizdaroglu M, Doetsch PW (1999) Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria. Biochemistry 38:11298-11306. 10.1021/bi991121i, 1:CAS:528:DyaK1MXkvF2qa70%3D, 10471279