The pso mutants of Saccharomyces cerevisiae comprise two groups: One deficient in DNA repair and another with altered mutagen metabolism

Mutation Research - Reviews in Mutation Research

Volumn 489, Issue 1, 2001, Pages 79-96

  Brendel, Martin ^a   Henriques, João Antonio P ^b  

^a GOETHE UNIVERSITY   (Germany)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cross link repair; Cytochrome c oxidase; DNA repair; Egosterol; Mutagenesis; Pre mRNA spilicing; Psoralen sensitivity; Yeast

Indexed keywords

MUTAGENIC AGENT; PSORALEN;

ALLELE; CROSS LINKING; DNA DAMAGE; DNA REPAIR; GENE ISOLATION; GENE LOCUS; GENE MUTATION; GENE STRUCTURE; GENETIC CODE; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PHENOTYPE; PHOTOACTIVATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVIEW; RNA SPLICING; SACCHAROMYCES CEREVISIAE; XENOBIOTIC METABOLISM;

DNA REPAIR; HUMANS; MUTAGENS; MUTATION; NUCLEIC ACIDS; PHENOTYPE; PSORALENS; RNA PROCESSING, POST-TRANSCRIPTIONAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0034779850     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(01)00066-7     Document Type: Review

References (167)

1. Indications and action mechanisms of phototherapy
2. Evidences of a photoreaction of the photosensitizing furocoumarins with DNA and with pyrimidine nucleosides
3. Molecular and genetic basis of furocoumarin reactions
4. Mode of photosensitizing action of furocoumarins
5. Skin photosensitization and crosslinking formation in native DNA by furocoumarins
6. Isolation and characterization of pso mutants sensitive to photoaddition of psoralen derivatives in Saccharomyces cerevisiae
7. The role of PSO and SNM genes in dark repair of the yeast Saccharomyces cerevisiae
8. Role of PSO genes in the repair of photoinduced interstrand cross-links and photooxidative damage in the DNA of the yeast Saccharomyces cerevisiae
9. The effects of the three PSO genes on induced mutagenesis: A novel class of mutationally defective yeast
10. Mutagenesis induced by mono- and bi-functional alkylating agents in yeast mutants sensitive to photo-addition of furocoumarins (pso)
11. PSO4: A novel gene involved in error-prone repair in Saccharomyces cerevisiae
12. The PSO3 gene is involved in error-prone intragenic recombinational DNA repair in Saccharomyces cerevisiae
13. The PSO4 gene is responsible for an error-prone recombinational DNA repair pathway in Saccharomyces cerevisiae
14. The Saccharomyces repair genes at the end of the century
15. Epistatic interactions between four Rad loci in yeast
16. Interactions among genes controlling sensitivity to radiation and alkylation in yeast
17. The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
18. Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiae
19. Mutants of yeast defective in mutation induced by ultraviolet light
20. Thymine-thymine dimer bypass by yeast polymerase zeta
21. DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes
22. Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expression
23. DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae
24. Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae
25. POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathway
26. DNA damage-induced mutation: Tolerance via translesion synthesis
27. Identification of genes affecting selenite toxicity and resistance in Saccharomyces cerevisiae
28. A phylogenomic study of DNA repair genes, proteins, and processes
29. The uvs1 gene of Aspergillus nidulans required for UV-mutagenesis encodes a homolog to REV3, a subunit of the DNA polymerase zeta of yeast involved in translesion DNA synthesis
30. Isolation and genetic characterisation of the Drosophila homologue of (SCE) REV3, encoding the catalytic subunit of DNA polymerase zeta
31. Molecular cloning, expression and chromosomal localisation of the mouse Rev3L gene, encoding the catalytic subunit of polymerase zeta
32. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta
33. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans
34. Alternative splicing, genomic structure, and fine chromosome localization on REV31
35. Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs bastocyst development in vitro
36. Disruption of the developmentally regulated rev31 gene causes embryonic lethality
37. Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality
38. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta
39. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
40. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light
41. The translesion DNA polymerase zeta plays a major role in Ig and blc-6 somatic hypermutation
42. The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues
43. A yeast mutant specifically sensitive to bifunctional alkylation
44. Relationships between functionality and genetic toxicology of selected DNA-damaging agents
45. DNA alkylation by mustard gas in yeast strains of different repair capacity
46. Formation and fate of cross-links induced by polyfunctional anticancer drugs in yeast
47. Molecular dosimetry of 8-MOP + UVA-induced DNA photoadducts in Saccharomyces cerevisiae: Correlation of lesion number with genotoxic potential
48. Formation and stability of interstrand cross-links induced by cis- and trans-diamminedichloroplatinum(II) in the DNA of Saccharomyces cerevisiae strains differing in repair capacity
49. Further phenotypic characterisation of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress
50. Sensitivity of pso2 mutants of Saccharomyces cerevisiae to the interstrand cross-link producing acetaldehyde
51. The fate of 8-methoxypsoralen photoinduced cross-links in nuclear and mitochondrial yeast DNA: Comparison of wild-type and repair deficient strains
52. Photochemistry of DNA: Secondary structure, photosensitization, base substitution, and exogenous molecules
53. Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation
54. Characterization of a unique protein component of yeast Rnase MRP: An RNA-binding protein with a zinc-cluster domain
55. Isolation and characterization of yeast mutants with thermoconditional sensitivity to the bifunctional alkylating agent nitrogen mustard
56. A single amino acid change in SNM1-encoded protein leads to thermoconditional deficiency for DNA cross-link repair in Saccharomyces cerevisiae
57. Molecular structure of the DNA cross-link repair gene SNM1 (PSO2) of the yeast Saccharomyces cerevisiae
58. Regulation of SNM1, an inducible Saccharomyces cerevisiae gene required for repair of DNA cross-links
59. Regulation of the yeast RAD2 gene: DNA damage-dependent induction correlates with protein binding to regulatory sequences and their deletion influences survival
60. Molecular characterization of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein
61. Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems of DNA repair: The RAD3 system and the RAD51 system
62. Repair of exogenous (plasmid) DNA damaged by photoaddition of 8-methoxypsoralen in the yeast Saccharomyces cerevisiae
63. Preferential repair in Saccharomyces cerevisiae rad mutants after induction of interstrand cross-links by 8-methoxypsoralen plus UVA
64. 2 after cisplatin treatment
65. Hyperresistance to formaldehyde of Saccharomyces cerevisiae seems not correlated with formation and removal of DNA-protein cross-links
66. The Walker 256 carcinoma: A cell type inherently sensitive only to those difuctional agents that can form DNA interstrand crosslinks
67. The cytogenetic response of Fanconi's anemia lymphoblastoid cell lines to various clastogens
68. Fanconi anemia cells are not uniformly deficient in unhooking of DNA interstrand crosslinks, induced by mitomycin C or 8-methoxypsoralen plus UVA
69. Overexpression of cDNA encoding FANCC, SPHAR, MPG, SNM1, or HA3611 does not render CHO cells more resistant to DNA crosslinking agents
70. Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086
71. Disruption of mouse SNM1 causes increased sensitivity to the interstrand cross-linking agent mitomycin C
72. A candidate prostate cancer susceptibility gene at chromosome 17p
73. Genetical control of excision of Saccharomyces cerevisiae interstrand DNA cross-links induced by psoralen plus near-UV light
74. A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae
75. The formation of pyrimidine dimers in the DNA of fungi and bacteria
76. UV-induction of thymine-containing dimers in Saccharomyces cerevisiae
77. Genetic effects of photoactivated psoralens during meiosis in DNA repair mutant pso3 of Saccharomyces cerevisiae
78. Involvement of the PSO3 gene of Saccharomyces cerevisiae in intrachromosomal mitotic recombination and gene amplification
79. Low glutathione pools in the original pso3 mutant of Saccharomyces cerevisiae are responsible for its pleiotropic sensitivity phenotype
80. The DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group
81. Further characterization of the pso3-1 mutant of S. cerevisiae: Functional expression of the E. coli endonuclease III
82. Yeast redoxyendonuclease, a DNA repair enzyme similar to Escherichia coli endonuclease III
83. Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III
84. Saccharomyces cerevisiae Ntgp1 and Ntgp2: Broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria
85. UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
86. The genetic control of X-ray resistance of budding yeast cells
87. Allelism of PSO4 and PRP19 links pre-mRNA processing with recombination and error-prone DNA-repair in Saccharomyces cerevisiae
88. The yeast Prp19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome
89. Prp19: A novel spliceosomal component
90. Thermoconditional modulation of pleiotropic sensitivity phenotype is a result of altered splicing capacity in the pso4-1 mutant of Saccharomyces cerevisiae
91. Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins
92. Isolation and sequence of the gene for actin in Saccharomyces cerevisiae
93. Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing
94. Snt309p, a component of the Prp19p-associated complex that interacts with prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p
95. Identification and characterization of two novel components of the Prp1pp-associated complex, Ntc30p and Ntc20p
96. Isolation and characterization of three mutants with increased sensitivity to photoactivated 3-carbethoxypsoralen in Saccharomyces cerevisiae
97. Oxydative DNA damage photoinduced by 3-carbethoxypsoralen and other furocoumarins: Mechanisms of photo-oxidation and recognition by repair enzymes
98. New aspects of the repair and genotoxicity of psoralen photoinduced lesions in DNA
99. Gene PSO5 of Saccharomyces cerevisiae, involved in repair of oxidative damage, is allelic to RAD
100. Cloning of RAD16, a gene involved in differential repair in Saccharomyces cerevisiae
101. Indentification of RAD16, a yeast excision repair gene homologous to the recombinational repair gene RAD54 and to the SNF2 gene involved in transcriptional activation
102. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahama are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor
103. The RAD7 and RAD16 genes, which are essential for pyrimidine dimer removal from the silent mating type loci, are also required for repair of nontranscribed strand of an active gene in Saccharomyces cerevisiae
104. Yeast Rad7-Rad16 complex, specific for the nucleotide excision repair of nontranscribed DNA strand, is a ATP-dependent DNA damage sensor
105. The DNA-dependent ATPase activity of yeast nucleotide excision repair factor 4 and its role in DNA damage recognition
106. Nucleotide excision repair in yeast
107. The yeast RAD7 and RAD16 genes are required for postincision events during nucleotide excision repair
108. Synergistic interaction between yeast nucleotide excision repair factors NEF2 and NEF4 in the binding of ultraviolet-damaged DNA
109. The Saccharomyces cerevisiae gene PSO5/RAD16 is involved in the regulation of DNA damage-inducible genes RNR2 and RNR
110. RAD9 and DNA polymerase epsilon form parallel sensory branches for tranducing the DNA damage checkpoint signal in Saccharomyces cerevisiae
111. DUN1 encodes a protein kinase that controls the DNA damage response in yeast
112. Interaction of the yeast Pso5/Rad16 and Sgs1 proteins: Influences on DNA repair and aging
113. Human homologues of yeast helicase
114. Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae
115. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
116. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
117. Do changes in chromosomes cause aging?
118. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
119. Molecular biology of aging
120. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
121. Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae
122. Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae
123. Requirement of yeast SGS1 and SRS2 genes for replication and transcription
124. Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins
125. A radical solution to death
126. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
127. Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae
128. The pso8-1 mutant of Saccharomyces cerevisiae, that is sensitive to radiation and to chemical mutagens, contains a RAD6 mutant allele
129. A Saccharomyces cerevisiae phleiomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene
130. The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity
131. Characterization of novel rad6/ubc2 ubiquitin-conjugating enzyme mutants in yeast
132. DNA repair genes and proteins of Saccharomyces cerevisiae
133. Allelism of Saccharomyces cerevisiae genes PSO6, involved in survival after 3-CPs + UVA induced damage, and ERG3, encoding the enzyme sterol C-5 desaturase
134. The ERG3 gene in Saccharomyces cerevisiae is required for the utilization of respiratory substrates and in heme-deficient cells
135. The plasma membrane of Saccharomyces cerevisiae: Structure, function and biogenesis
136. Toxic drug-effects associated with oxygen metabolism: Redox cycling and lipid peroxidation
137. Rapid oxidative stress induced by N-nitrosamines
138. Enhancement by tamoxigfen of the membrane antioxidant action of the yeast membrane sterol ergosterol: Relevance to the antiyeast and anticancer action of tamoxifen
139. Photochemical reaction and phototoxicity of sterols: Novel self-perpetuation mechanism for lipid photooxidation
140. A role for sterols in the porphyrin mediated photosensitization of yeast
141. Effects of singlet oxygen on membrane sterols in the yeast Saccharomyces cerevisiae
142. Mutant allele pso7-1, that sensitizes Saccharomyces cerevisiae to photoactivated psoralen, is allelic with COX11, encoding a protein indispensable for a functional cytochrome c oxidase
143. Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3
144. The respiratory chain in yeast behaves as a single functional unit
145. 1 complex of Saccharomyces cerevisiae: Effect on cytochome c oxidase, respiration and growth rate
146. Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide
147. Mutagenicity of 80 chemicals in Escherichia coli tester strains IC203, deficient in OxyR, and its oxyR(+) parent WP2 uvrA/pKM101: Detection of 31 oxidative mutagens
148. Active oxygen generated in the process of carcinogen metabolism can induce oxidative damage in nuclei
149. Carcinogenic nitrosamines: Free radical aspects of their action
150. Oxygen toxicity: A radical explanation
151. Biochemistry of free radicals: From electrons to tissues
152. On the metabolism of quinoline and isoquinoline: Possible molecular basis for differences in biological activities
153. Comparison of the mutagenicity of quinoline and all monohydroxyquinolines with a series of arene oxide, trans-dihydrodiol, diol epoxide, N-oxide and arene hydrate derivatives of quinoline in the Ames/Salmonella microsome test
154. Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides
155. Deletogenic activity of 1,2:7,8-diepoxyoctane in the Salmonella typhimurium tester strain TA102
156. Genome wide expression patterns in Saccharomyces cerevisiae: Comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol
157. Molecular cloning of SNM1, a yeast gene responsible for a specific step in the repair of cross-linked DNA
158. hNMP 200: A novel human common nuclear matrix protein combining structural and regulatory functions
159. Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter
160. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member
161. Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase
162. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain
163. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31