Regulation of biliary cholesterol secretion is independent of hepatocyte canalicular membrane lipid composition: A study in the diosgenin-fed rat model

Journal of Hepatology

Volumn 35, Issue 2, 2001, Pages 164-169

  Nibbering, Catharina P ^a   Groen, Albert K ^a   Ottenhoff, Roelof ^a   Brouwers, Jos F H M ^a   VanBerge Henegouwen, Gerard P ^a   Van Erpecum, Karel J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Bile; Canalicular membrane; Cholesterol; Detergent resistant membrane complexes; Diosgenin; Phosphatidylcholine; Phospholipids; Sphingomyelin

Indexed keywords

CHOLESTEROL; DETERGENT; DIOSGENIN; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SPHINGOMYELIN; STEROL; TAUROCHOLIC ACID; TYLOXAPOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT FISTULA; BILE FLOW; BILE SECRETION; CELL MEMBRANE; CONTROLLED STUDY; HYDROPHILICITY; INTRAHEPATIC BILE DUCT; LIPID COMPOSITION; LIPID MEMBRANE; LIVER CELL; MALE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; RAT;

ANIMALS; BILE; CHOLESTEROL; DETERGENTS; DIET; DIOSGENIN; HEPATOCYTES; MALE; MEMBRANE LIPIDS; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; PHYTOSTEROLS; RATS; RATS, WISTAR; SOLUBILITY; SPHINGOMYELINS;

EID: 0034866889     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00125-8     Document Type: Article

References (43)

1. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
2. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
3. The lipid composition of plasma membrane subfractions originating from the three major functional domains of the rat hepatocyte cell surface
4. Molecular composition of biliary phosphatidylcholines, as related to cholesterol saturation, transport and nucleation in human gallbladder bile
5. The preferential interaction of cholesterol with different classes of phospholipids
6. Influence of molecular packing and phospholipid type on rates of cholesterol exchange
7. The affinity of cholesterol for phosphatidylcholine and sphingomyelin
8. Asymmetric distribution of phospbatidylcholine and sphingomyelin between micellar and vesicular phases: Potential implications for canalicular bile formation
9. Structure of detergent-resistant membrane domains: Does phase separation occur in biological membranes?
10. Caveolae, DIGs, and the dynamics of sphingolipid - Cholesterol microdomains
11. Regulation of billiary cholesterol secretion in rat. Role of hepatic cholesterol esterification
12. Effect of diosgenin on biliary cholesterol transport in the rat
13. Fractionation of livers following diosgenin treatment to elevate billary cholesterol
14. Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage
15. Protein measurement with Folin phenol reagent
16. Enzymatic determination of total serum cholesterol
17. Reevaluation of the 3α-hydroxysteroid dehydrogenase assay for total bile acids in bile
18. Enzymatic measurement of choline-containing phospholipids in bile
19. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots
20. A simple method for isolation and purification of total lipids from animal tissues
21. Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver
22. High-performance liquid chromatography of phosphatidylcholine and sphingomyelin with detection in the region of 200 nm
23. Analysis of lipids of ceramides derived from human plasma sphingomyelins
24. Novel quantitative method for determination of molecular species of phospholipids and diglycerides
25. Quantitative analysis of plasma neutral glycosphingolipids by high performance liquid chromatography of their perbenzoyl derivatives
26. HPLC of molecular species of glycerophospholipids in studies of lipoproteins and lipid transport
27. Separation of brain monoganglioside molecular species by high performance liquid chromatography
28. Quantitative analysis of phosphatidylcholine molecular species using HPLC and light scattering detection
29. Cholesterol and sphingolipid enhance the triton X-100 insolubility of glycosyl-phosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains
30. Solubilization of lipids from hamster bile-canalicular and contiguous membranes and from human erythrocyte membranes by conjugated bile salts
31. Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts
32. Analysis of the distribution of cholesterol in the intact cell
33. Tracking cell cholesterol with cholesterol oxidase
34. Effect of diosgenin on lipid metabolism in rats
35. Regulation of biliary cholesterol secretion
36. The hepatocyte plasma membrane: Organization and differentiation
37. Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage
38. Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: Relevance to bile formation and stability
39. Metabolism of individual molecular species of phosphatidylcholine in the liver subcellular membranes and bile. Origin of bile phosphatidylcholine
40. Sphingomyelins of rat liver: Biliary enrichment with molecular species containing 16:0 fatty acids as compared to canalicular-enriched plasma membranes
41. Taurocholate induces preferential release of phosphatidylcholine from rat liver canalicular vesicles
42. In vitro effect of free bile acids on the bile canalicular membrane phospholipids in the rat
43. Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat