Inactivation of imprinted genes induced by cellular stress and tumorigenesis

Cancer Research

Volumn 65, Issue 1, 2005, Pages 26-33

  Pantoja, Cristina ^a   De Los Ríos, Laura ^b   Matheu, Ander ^a   Antequera, Francisco ^b   Serrano, Manuel ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ARTICLE; CANCER CELL; CARCINOGENESIS; CDKN1C GENE; CELL CULTURE; CELL PROLIFERATION; CELL STRESS; CELL SUBPOPULATION; CONTROLLED STUDY; CPG ISLAND; CULTURE MEDIUM; DNA METHYLATION; EMBRYO; EPIGENETICS; EXPRESSED SEQUENCE TAG; FIBROBLAST; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; GENETIC EPIGENESIS; GENETIC SCREENING; GENOME IMPRINTING; GENOTYPE; GRB10 GENE; H19 GENE; IGF2 GENE; MEG3 GENE; MOUSE; NDN1 GENE; NONHUMAN; OXIDATIVE STRESS; P16 INK4A GENE; P19 ARF GENE; PRIORITY JOURNAL; PROMOTER REGION; RNA HYBRIDIZATION; SCREENING TEST; SENESCENCE; STRESS; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA PRIMERS; EMBRYO; FIBROBLASTS; FIBROSARCOMA; GENOMIC IMPRINTING; MALE; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEIC ACID HYBRIDIZATION; POLYMERASE CHAIN REACTION; Y CHROMOSOME;

EID: 11244259404     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
2. Serrano M, Blasco MA. Putting the stress on senescence. Curr Opin Cell Biol 2001;13:748-53.
3. Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell 2000;102:407-10.
4. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003;5:741-7.
5. Ramirez RD, Morales CP, Herbert BS, et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 2001;15:398-403.
6. Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397:164-8.
7. Itahana K, Zou Y, Itahana Y, et al. Control of the replicative life span of human fibroblasts by p16 and the Polycomb protein Bmi-1. Mol Cell Biol 2003;23:389-401.
8. Narita M, Nunez S, Heard E, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003;113:703-16.
9. Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet 2001;2:21-32.
10. Dean W, Bowden L, Aitchison A, et al. Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes. Development 1998;125:2273-82.
11. Humpherys D, Eggan K, Akutsu H, et al. Epigenetic instability in ES cells and cloned mice. Science 2001;293:95-7.
12. Khosla S, Dean W, Brown D, Reik W, Feil R. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod 2001;64:918-26.
13. Fernandez-Gonzalez R, Moreira P, Bilbao A, et al. Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proc Natl Acad Sci U S A 2004;101:5880-5.
14. Jacks T, Remington L, Williams BO, et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994;4:1-7.
15. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996;85:27-37.
16. Palmero I, Serrano M. Induction of senescence by oncogenic Ras. Methods Enzymol 2001;333:247-56.
17. Lavrovsky Y, Song CS, Chatterjee B, Roy AK. A rapid and reliable PCR-based assay for gene transmission and sex determination in newborn transgenic mice. Transgenic Res 1998;7:319-20.
18. Barradas M, Gonos ES, Zebedee Z, et al. Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp Cell Res 2002;273:127-37.
19. Wexler H, Rosenberg SA. Pulmonary metastases from autochthonous 3-methylcholanthrene-induced murine tumors. J Natl Cancer Inst 1979;63:1393-5.
20. Ozaki K, Sukata T, Yamamoto S, et al. High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Cancer Res 1998;58:3806-11.
21. Yamamoto S, Tatematsu M, Yamamoto M, Fukami H, Fukushima S. Clonal analysis of urothelial carcinomas in C3H/HeN↔BALB/c chimeric mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis 1998;19:855-60.
22. Malumbres M, Perez de Castro I, Santos J, et al. Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas. Oncogene 1997;14:1361-70.
23. Clark SJ, Harrison J, Paul CL, Frommer M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res 1994;22:2990-7.
24. Matsuoka S, Thompson JS, Edwards MC, et al. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc Natl Acad Sci U S A 1996;93:3026-30.
25. Weksberg R, Smith AC, Squire J, Sadowski P. Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development. Hum Mol Genet 2003;12:R61-8.
26. Pantoja C, Serrano M. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene 1999;18:4974-82.
27. Zindy F, Quelle DE, Roussel MF, Sherr CJ. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 1997;15:203-11.
28. Enklaar T, Esswein M, Oswald M, et al. Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Genomics 2000;67:179-87.
29. Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol Cell Biol 1998;18:3466-74.
30. Antequera F, Bird A. CpG islands as genomic footprints of promoters that are associated with replication origins. Curr Biol 1999;9:R661-7.
31. Antequera F. Structure, function and evolution of CpG island promoters. Cell Mol Life Sci 2003;60:1647-58.
32. Cuadrado M, Sacristan M, Antequera F. Species-specific organization of CpG island promoters at mammalian homologous genes. EMBO Rep 2001;2:586-92.
33. Lee JT. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting? Curr Biol 2003;13: R242-54.
34. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002;3:662-73.
35. Baylin S, Bestor TH. Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell 2002;1:299-305.
36. Eversole-Cire P, Ferguson-Smith AC, Sasaki H, et al. Activation of an imprinted Igf 2 gene in mouse somatic cell cultures. Mol Cell Biol 1993;13:4928-38.
37. Issa JP, Vertino PM, Boehm CD, Newsham IF, Baylin SB. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A 1996;93:11757-62.
38. Mermoud JE, Popova B, Peters AH, Jenuwein T, Brockdorff N. Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Curr Biol 2002;12:247-51.
39. Mutskov V, Felsenfeld G. Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J 2004;23:138-49.
40. Thompson JS, Reese KJ, DeBaun MR, Perlman EJ. Feinberg AP. Reduced expression of the cyclin-dependent kinase inhibitor gene p57KIP2 in Wilms' tumor. Cancer Res 1996;56:5723-7.
41. Li Y, Nagai H, Ohno T, et al. Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype. Blood 2002;100:2572-7.
42. Shin JY, Kim HS, Park J, Park JB, Lee JY. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. Cancer Res 2000;60:262-5.
43. Kikuchi T, Toyota M, Itoh F, et al. Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors. Oncogene 2002;21:2741-9.
44. Schwienbacher C, Gramantieri L, Scelfo R, et al. Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas. Proc Natl Acad Sci U S A 2000;97:5445-9.
45. Maegawa S, Yoshioka H, Itaba N, et al. Epigenetic silencing of PEG3 gene expression in human glioma cell lines. Mol Carcinog 2001;31:1-9.
46. Yuan J, Luo RZ, Fujii S, et al. Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. Cancer Res 2003;63:4174-80.
47. Velicescu M, Weisenberger DJ, Gonzales FA, Tsai YC, Nguyen CT, Jones PA. Cell division is required for de novo methylation of CpG islands in bladder cancer cells. Cancer Res 2002;62:2378-84.
48. Kanduri C, Kanduri M, Liu L, Thakur N, Pfeifer S, Ohlsson R. The kinetics of deregulation of expression by de novo methylation of the h19 imprinting control region in cancer cells. Cancer Res 2002;62:4545-8.
49. Ying AK, Hassanain HH, Roos CM, et al. Methylation of the estrogen receptor-α gene promoter is selectively increased in proliferating human aortic smooth muscle cells. Cardiovasc Res 2000;46:172-9.
50. Colot V, Maloisel L, Rossignol JL. Interchromosomal transfer of epigenetic states in Ascobolus: transfer of DNA methylation is mechanistically related to homologous recombination. Cell 1996;86:855-64.
51. Delaval K, Feil R. Epigenetic regulation of mammalian genomic imprinting. Curr Opin Genet Dev 2004;14:188-95.
52. Morris KV, Chan SW, Jacobsen SE, Looney DJ. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 2004;305:1289-92.
53. Kawasaki H, Taira K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 2004;431:211-7.
54. Rideout WM III, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001;293:1093-8.
55. Ogonuki N, Inoue K, Yamamoto Y, et al. Early death of mice cloned from somatic cells. Nat Genet 2002;30:253-4.