Epitope mapping of anti-MUC1 mucin protein core monoclonal antibodies

Tumor Biology

Volumn 19, Issue SUPPL.1, 1997, Pages 21-29

  Petrakou, Eftichia ^a   Murray, Andrea ^a   Price, Michael R ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Antibody specificity; MUC1 mucin; Peptide epitopes

Indexed keywords

MONOCLONAL ANTIBODY; MUCIN; TUMOR MARKER;

ANTIBODY SPECIFICITY; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; MALIGNANT TRANSFORMATION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PURIFICATION; PROTEIN STRUCTURE; TANDEM REPEAT;

EID: 0031469785     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056501     Document Type: Conference Paper

References (16)

1. Gendler S, Spicer AP, Lalani E-N, Duhig T, Peat N, Burchell J, Pemberton L, Boshell M, Taylor-Papadimitriou J: Structure and biology of a carcinoma-associated mucin, MUC-1. Am Rev Respir Dis 1991;144:S42-S47.
2. Kim YS, Gum JR, Byrd JC, Toribara N: The structure of human intestinal apomucins. Am Rev Respir Dis 1991;144:S10-S14.
3. Price MR, Tendler SJB: Polymorphic epithelial mucins: Molecular characteristics and association with breast cancer. Breast 1993;2:3-7.
4. Gendler SJ, Taylor-Papdimitriou J, Duhig T, Rothbard J, Burchell J: A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J Biol Chem 1988;263:12820-12823.
5. Singhal A, Hakomori S-I: Molecular changes in carbohydrate antigens associated with cancer. Bioessays 1990;12:223-230.
6. Ho SB, Kim YS: Carbohydrate antigens on cancer-associated mucin-like molecules. Semin Cancer Biol 1992;2:389-400.
7. Hull S, Bright A, Carraway K, Abe M, Hayes D, Kufe D: Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT20 human breast carcinoma cell line. Cancer Commun 1989;1:261-267.
8. Burchell J, Taylor-Papadimitriou J, Boshell M, Gendler S, Duhig T: A short sequence within the amino acid tandem repeat of a cancer-associated mucin contains immuno-dominant epitopes. Int J Cancer 1989;44:691-696.
9. Price MR, Hudecz F, O'Sullivan C, Baldwin RW, Edwards PM, Tendler SJB: Immunological and structural features of the protein core of human polymorphic epithelial mucins. Mol Immunol 1990;27:795-802.
10. Xing PX, Tjandra J, Reynolds K, McLaughlin PJ, Purcell DFJ, McKenzie IFC: Reactivity of antihuman milk fat globule antibodies with synthetic peptides. J Immunol 1989;142:3503-3509.
11. Taylor-Papadimitriou J: Report on the First International Workshop on Carcinoma-Associated Mucins. Int J Cancer 1991;49:1-5.
12. Geysen HM, Rodda SJ, Mason RJ, Tribbick G, Schoofs PG: Strategies for epitope analysis using peptide synthesis. J Immunol Methods 1987;102:259-274.
13. Price MR, Pugh JA, Hudecz F, Griffiths W, Jacobs E, Clarke AJ, Chan WC, Baldwin RW: C595 - A monoclonal antibody against the protein core of human urinary epithelial mucin commonly expressed in breast carcinomas. Br J Cancer 1990;61:681-686.
14. Briggs S, Price MR, Tendler SBJ: Fine specificity of antibody recognition of breast carcinoma-associated epithelial mucins: Antibody binding to synthetic peptide epitopes. Eur J Cancer 1993;29A:230-237.
15. Price MR, Petrakou E, Sekowski M, Murray A: Immunogenicity of the hydrophilic region of the MUC1 mucin protein core. Oncol Rep 1997;4:337-339.
16. a carrying glycoproteins produced by colon carcinoma cells using a novel monoclonal antibody. Cancer Res 1993;53:755-761.