Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins

Nature Biotechnology

Volumn 17, Issue 11, 1999, Pages 1116-1121

  Weikert, S ^a   Papac, D ^a   Briggs, J ^a   Cowfer, D ^a   Tom, S ^a   Gawlitzek, M ^a   Lofgren, J ^a   Mehta, S ^a   Chisholm, V ^a   Modi, N ^a   Eppler, S ^a   Carroll, K ^a   Chamow, S ^a   Peers, D ^a   Berman, P ^a   Krummen, L ^a  

^a GENENTECH INC   (United States)

Author keywords

Chinese hamster ovary cells; Glycosylation; Glycosyltransferase overexpression; Recombinant protein expression

Indexed keywords

BETA N ACETYLGLUCOSAMINYLGLYCOPEPTIDE BETA 1,4 GALACTOSYLTRANSFERASE; GLYCOPROTEIN; RECOMBINANT PROTEIN; SIALIC ACID; SIALYLTRANSFERASE;

ANIMAL CELL; ARTICLE; BIOENGINEERING; CHO CELL; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION;

ANIMALS; CHO CELLS; CRICETINAE; GALACTOSYLTRANSFERASES; GENETIC ENGINEERING; GLYCOPROTEINS; N-ACETYLNEURAMINIC ACID; RABBITS; RECOMBINANT PROTEINS; SIALYLTRANSFERASES;

EID: 0032693972     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/15104     Document Type: Article

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