Achievement of high cell density and high antibody productivity by a controlled-fed perfusion bioreactor process

Biotechnology and Bioengineering

Volumn 69, Issue 1, 2000, Pages 74-82

  Yang, Jeng Dar ^a   Angelillo, Yale ^a   Chaudhry, Mina ^a   Goldenberg, Cindy ^a   Goldenberg, David M ^b  

^a IMMUNOMEDICS INC   (United States)

^b GARDEN STATE CANCER CENTER   (United States)

Author keywords

Bioreactor; Cell culture; Controlled feed perfusion; Fed batch; Monoclonal antibody; Nutrient feeding; Perfusion

Indexed keywords

BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE; CELLS; DNA SEQUENCES; FEEDING; PRODUCTIVITY;

CONTROLLED FED PERFUSION; NUTRIENT FEEDING;

MONOCLONAL ANTIBODIES;

EPRATUZUMAB; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CELL CULTURE; CELL DENSITY; CLINICAL TRIAL; DRUG MANUFACTURE; HUMAN; NONHODGKIN LYMPHOMA; NUTRIENT; PERFUSION; VOLUMETRY;

EID: 0034609009     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(20000705)69:1<74::AID-BIT9>3.0.CO;2-K     Document Type: Article

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