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Volumn 134, Issue 47-48, 2004, Pages 685-694

Molecular and clinical determinants of drug-induced long QT syndrome: An iatrogenic channelopathy

Author keywords

Adverse drug reaction; Arrhythmias; Long QT syndrome; Pharmacogenetics; Torsades de pointes

Indexed keywords

ADRENALINE SINTETICA; AMIODARONE; AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIMALARIAL AGENT; CARDIOVASCULAR AGENT; CHLORAL HYDRATE; CHLORPROMAZINE; CITALOPRAM; CITALOPRAM MEPHA; CLOMIPRAMINE; DISOPYRAMIDE; DISOPYRAMIDE PHOSPHATE; DOBUTAMINE; DOPAMINE; DOXEPIN; DROPERIDOL; EPHEDRIN STREULI; EPHEDRINE; FELBAMATE; FLECAINIDE; FLECAINIDE ACETATE; FLUDAPAMIDE; FLUOXETINE; FLUPENTIXOL; IBUTILIDE; IBUTILIDE FUMARATE; INDAPAMIDE; ISRADIPINE; KINIDIN DURILES; LOMIR SRO; MAGNESIUM SULFATE; MEPIVACAINE; MIDODRINE; NEUROTROPIC AGENT; NORADRENALIN; QUINIDINE; SOTALOL; UNINDEXED DRUG;

EID: 11144320454     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (74)

References (63)
  • 1
    • 0033530381 scopus 로고    scopus 로고
    • Long QT syndromes and torsade de pointes
    • Viskin S. Long QT syndromes and torsade de pointes. Lancet 1999; 354:1625-33.
    • (1999) Lancet , vol.354 , pp. 1625-1633
    • Viskin, S.1
  • 2
    • 1442306232 scopus 로고    scopus 로고
    • Drug-induced prolongation of the QT interval
    • Roden DM. Drug-Induced Prolongation of the QT Interval. N Engl J Med 2004;350:1013-22.
    • (2004) N Engl J Med , vol.350 , pp. 1013-1022
    • Roden, D.M.1
  • 3
    • 1942536148 scopus 로고    scopus 로고
    • Drug-induced torsades de pointes and implications for drug development
    • Fenichel RR, et al. Drug-Induced Torsades de Pointes and Implications for Drug Development. J Cardiovascular Electrophysiol 2004;15:475-95.
    • (2004) J Cardiovascular Electrophysiol , vol.15 , pp. 475-495
    • Fenichel, R.R.1
  • 5
    • 0030011760 scopus 로고    scopus 로고
    • Cardiac actions of antihistamines
    • Woosley RL. Cardiac actions of antihistamines. Ann Rev Pharmacol Toxicol 1996;36:233-52.
    • (1996) Ann Rev Pharmacol Toxicol , vol.36 , pp. 233-252
    • Woosley, R.L.1
  • 6
    • 0035212983 scopus 로고    scopus 로고
    • Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin
    • Frothingham R. Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. Pharmacotherapy 2001;21:1468-72.
    • (2001) Pharmacotherapy , vol.21 , pp. 1468-1472
    • Frothingham, R.1
  • 7
    • 11144326541 scopus 로고    scopus 로고
    • Methadon - Dosisabhängiges risiko von torsade de pointes/kammertachykardien und QT-verlängerung
    • Violand C, Piguet V. Methadon - dosisabhängiges Risiko von Torsade de pointes/Kammertachykardien und QT-Verlängerung. Swissmedic Journal 2004;3:17-8.
    • (2004) Swissmedic Journal , vol.3 , pp. 17-18
    • Violand, C.1    Piguet, V.2
  • 9
    • 0035936798 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of cardiac arrhythmias
    • Kearing MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 2001;104:569-80.
    • (2001) Cell , vol.104 , pp. 569-580
    • Kearing, M.T.1    Sanguinetti, M.C.2
  • 10
    • 76949111722 scopus 로고
    • Effect of current flow on the membrane potential of cardiac muscle
    • Weidmann S. Effect of current flow on the membrane potential of cardiac muscle. J Physiol 1951;115:227-36.
    • (1951) J Physiol , vol.115 , pp. 227-236
    • Weidmann, S.1
  • 11
    • 0030823390 scopus 로고    scopus 로고
    • Genetically induced reduction in small currents has major impact
    • Kass RS. (Genetically induced reduction in small currents has major impact. Circulation 1997;96:1720-1.
    • (1997) Circulation , vol.96 , pp. 1720-1721
    • Kass, R.S.1
  • 12
    • 0034711465 scopus 로고    scopus 로고
    • Probing the interaction between inactivation gating and Dd-sotalol block of HERG
    • Numaguchi H, et al. Probing the interaction between inactivation gating and Dd-sotalol block of HERG. Circ Res 2000; 87:1012-8.
    • (2000) Circ Res , vol.87 , pp. 1012-1018
    • Numaguchi, H.1
  • 13
    • 0030859887 scopus 로고    scopus 로고
    • The side effect profile of class III antiarrhythmic drugs: Focus on d,1-sotalol
    • MacNeil DJ. The side effect profile of class III antiarrhythmic drugs: focus on d,1-sotalol. Am J Cardiol 1997;80:90G-98G.
    • (1997) Am J Cardiol , vol.80
    • MacNeil, D.J.1
  • 14
    • 0034609531 scopus 로고    scopus 로고
    • Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
    • Splawski I, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 2000;102:1178-85.
    • (2000) Circulation , vol.102 , pp. 1178-1185
    • Splawski, I.1
  • 15
    • 75549109609 scopus 로고
    • Aritmie cardiache rare dell'età pediatrics
    • Romano C, Gemme G, Pongiglione & R. Aritmie cardiache rare dell'età pediatrics. Clin pediat 1963;45:656-83.
    • (1963) Clin Pediat , vol.45 , pp. 656-683
    • Romano, C.1    Gemme, G.2    Pongiglione, R.3
  • 16
    • 0000387603 scopus 로고
    • A new familial cardiac syndrome in children
    • Ward OC. A new familial cardiac syndrome in children. J Irish Med Assoc 1964;54:103-6.
    • (1964) J Irish Med Assoc , vol.54 , pp. 103-106
    • Ward, O.C.1
  • 17
    • 49749174698 scopus 로고
    • Congenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death
    • Jervell A, Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death. Am Heart J 1957;54:59-68.
    • (1957) Am Heart J , vol.54 , pp. 59-68
    • Jervell, A.1    Lange-Nielsen, F.2
  • 20
    • 11144328682 scopus 로고    scopus 로고
    • Study group on molecular basis of arrhythmias. Inherited Arrhythmias Database. 2004. http://pc4.fsm.it:81/cardmoc/, accessed September 7, 2004.
    • (2004) Inherited Arrhythmias Database
  • 21
    • 0034077362 scopus 로고    scopus 로고
    • Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: Time to revise current concepts
    • Volders PG, et al. Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. Cardiovasc Res 2000;46:376-92.
    • (2000) Cardiovasc Res , vol.46 , pp. 376-392
    • Volders, P.G.1
  • 22
    • 0035726691 scopus 로고    scopus 로고
    • Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias
    • Vos MA, van Opstal JM, Leunissen JD, Verduyn SC. Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias. Pharmacol Ther 2001;92:109-22.
    • (2001) Pharmacol Ther , vol.92 , pp. 109-122
    • Vos, M.A.1    Van Opstal, J.M.2    Leunissen, J.D.3    Verduyn, S.C.4
  • 23
    • 0001127258 scopus 로고
    • An analysis of the time relations of the electrocardiograms
    • Bazett HC. An analysis of the time relations of the electrocardiograms. Heart 1920;7:353-70.
    • (1920) Heart , vol.7 , pp. 353-370
    • Bazett, H.C.1
  • 24
    • 0030913917 scopus 로고    scopus 로고
    • Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings
    • Stramba-Badiale M, Locati EH, Martinelli A, Courville J, Schwartz PJ. Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings. Eur Heart J 1997;18:1000-6.
    • (1997) Eur Heart J , vol.18 , pp. 1000-1006
    • Stramba-Badiale, M.1    Locati, E.H.2    Martinelli, A.3    Courville, J.4    Schwartz, P.J.5
  • 26
    • 0035040834 scopus 로고    scopus 로고
    • Pharmacogenetics and drug-induced arrhythmias
    • Roden DM. Pharmacogenetics and drug-induced arrhythmias. Cardiovasc Res 2001;50:224-31.
    • (2001) Cardiovasc Res , vol.50 , pp. 224-231
    • Roden, D.M.1
  • 27
    • 0029794664 scopus 로고    scopus 로고
    • Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart
    • Drici MD, Burklow TR, Haridasse V, Glazer RI, Woosley RL. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation 1996;94:1471-4.
    • (1996) Circulation , vol.94 , pp. 1471-1474
    • Drici, M.D.1    Burklow, T.R.2    Haridasse, V.3    Glazer, R.I.4    Woosley, R.L.5
  • 28
    • 0034945769 scopus 로고    scopus 로고
    • Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome
    • Drici MD, Clement N. Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 2001;24:575-85.
    • (2001) Drug Saf , vol.24 , pp. 575-585
    • Drici, M.D.1    Clement, N.2
  • 30
    • 0037161355 scopus 로고    scopus 로고
    • Allelic variants in long-QT disease genes in patients with drug- associated torsades de pointes
    • Yang P, et al. Allelic variants in long-QT disease genes in patients with drug- associated torsades de pointes. Circulation 2002;105:1943-8.
    • (2002) Circulation , vol.105 , pp. 1943-1948
    • Yang, P.1
  • 31
    • 19244371485 scopus 로고    scopus 로고
    • KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome
    • Donger C, et al. KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome. Circulation 1997; 96:2778-81.
    • (1997) Circulation , vol.96 , pp. 2778-2781
    • Donger, C.1
  • 32
    • 0035313448 scopus 로고    scopus 로고
    • Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A
    • Piippo K, et al. Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A. Am J Cardiol 2001;87:909-11.
    • (2001) Am J Cardiol , vol.87 , pp. 909-911
    • Piippo, K.1
  • 33
    • 0037015231 scopus 로고    scopus 로고
    • Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation
    • Makita N, et al. Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation. Circulation 2002;106:1269-74.
    • (2002) Circulation , vol.106 , pp. 1269-1274
    • Makita, N.1
  • 34
    • 0034083759 scopus 로고    scopus 로고
    • Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias
    • Napolitano C, et al. Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. J Cardiovasc Electrophysiol 2000;11:691-6.
    • (2000) J Cardiovasc Electrophysiol , vol.11 , pp. 691-696
    • Napolitano, C.1
  • 35
    • 0037049999 scopus 로고    scopus 로고
    • Cardiac channelopathies
    • Marban E. Cardiac channelopathies. Nature 2002;415:213-8.
    • (2002) Nature , vol.415 , pp. 213-218
    • Marban, E.1
  • 36
    • 0034103168 scopus 로고    scopus 로고
    • Prolongation of the QT interval in heart failure occurs at low but not at high heart rates
    • Davey PP, Barlow C, Hart G. Prolongation of the QT interval in heart failure occurs at low but not at high heart rates. Clin Sci (Colch.) 2000;98:603-10.
    • (2000) Clin Sci (Colch.) , vol.98 , pp. 603-610
    • Davey, P.P.1    Barlow, C.2    Hart, G.3
  • 37
    • 0017843995 scopus 로고
    • QT interval prolongation as predictor of sudden death in patients with myocardial infarction
    • Schwartz PJ, Wolf S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction Circulation 1978;57:1074-7.
    • (1978) Circulation , vol.57 , pp. 1074-1077
    • Schwartz, P.J.1    Wolf, S.2
  • 38
    • 1242317690 scopus 로고    scopus 로고
    • Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: The ARIC study
    • Dekker JM, Crow RS, Hannan PJ, Schouten EG, Folsom AR. Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. J Am Coll Cardiol 2004;43:565-71.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 565-571
    • Dekker, J.M.1    Crow, R.S.2    Hannan, P.J.3    Schouten, E.G.4    Folsom, A.R.5
  • 39
    • 0028963033 scopus 로고
    • QT dispersion and mortality after myocardial infarction
    • Glancy JM, Garratt CJ, Woods KL, de Bono DR QT dispersion and mortality after myocardial infarction. Lancet 1995; 345:945-8.
    • (1995) Lancet , vol.345 , pp. 945-948
    • Glancy, J.M.1    Garratt, C.J.2    Woods, K.L.3    De Bono, D.R.4
  • 40
    • 0035189621 scopus 로고    scopus 로고
    • Assessment of QT dispersion as a prognostic marker for sudden death in a regional nonreferred hypertrophic cardiomyopathy cohort
    • Maron BJ, et al. Assessment of QT dispersion as a prognostic marker for sudden death in a regional nonreferred hypertrophic cardiomyopathy cohort. Am J Cardiol 2001;87:114-5, A9.
    • (2001) Am J Cardiol , vol.87 , pp. 114-115
    • Maron, B.J.1
  • 41
    • 0026579841 scopus 로고
    • Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes
    • Kurita T, et al. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes. Am J Cardiol 1992;69:628-33.
    • (1992) Am J Cardiol , vol.69 , pp. 628-633
    • Kurita, T.1
  • 42
    • 0022597025 scopus 로고
    • Polymorphous ventricular tachycardia and atrioventricular block
    • Strasberg B, et al. Polymorphous ventricular tachycardia and atrioventricular block. Pacing Clin. Electrophysiol 1986;9:522-6.
    • (1986) Pacing Clin Electrophysiol , vol.9 , pp. 522-526
    • Strasberg, B.1
  • 45
    • 0036512453 scopus 로고    scopus 로고
    • Development of drugs that alter ventricular repolarization
    • Fenichel RR. Development of drugs that alter ventricular repolarization. Am J Ther 2002;9:127-39.
    • (2002) Am J Ther , vol.9 , pp. 127-139
    • Fenichel, R.R.1
  • 46
    • 0035987783 scopus 로고    scopus 로고
    • Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine
    • Paul AA, Witchel HJ, Hancox JC. Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine. Br J Pharmacol 2002;136:717-29.
    • (2002) Br J Pharmacol , vol.136 , pp. 717-729
    • Paul, A.A.1    Witchel, H.J.2    Hancox, J.C.3
  • 47
    • 0032582287 scopus 로고    scopus 로고
    • Compared effects of sotalol, flecainide and propafenone on ventricular repolarization in patients free of underlying structural heart disease
    • Sarubbi B, Ducceschi V, Briglia N, Mayer MS, Santangelo L, Iacono A. Compared effects of sotalol, flecainide and propafenone on ventricular repolarization in patients free of underlying structural heart disease. Int J Cardiol 1998;66:157-64.
    • (1998) Int J Cardiol , vol.66 , pp. 157-164
    • Sarubbi, B.1    Ducceschi, V.2    Briglia, N.3    Mayer, M.S.4    Santangelo, L.5    Iacono, A.6
  • 48
    • 0034636115 scopus 로고    scopus 로고
    • Effects of flecainide in patients with new SCN5A mutation: Mutation-specific therapy for long-QT syndrome?
    • Benhorin J, et al. Effects of flecainide in patients with new SCN5A mutation: mutation-specific therapy for long-QT syndrome? Circulation 2000;101:1698-706.
    • (2000) Circulation , vol.101 , pp. 1698-1706
    • Benhorin, J.1
  • 49
    • 0034702931 scopus 로고    scopus 로고
    • Molecular pharmacology of the sodium channel mutation D179OG linked to the long QT syndrome
    • Abriel H, Wehrens XHT, Benhorin J, Kerem B, Kass RS. Molecular pharmacology of the sodium channel mutation D179OG linked to the long QT syndrome. Circulation 2000;102:921-5.
    • (2000) Circulation , vol.102 , pp. 921-925
    • Abriel, H.1    Wehrens, X.H.T.2    Benhorin, J.3    Kerem, B.4    Kass, R.S.5
  • 50
    • 0028292927 scopus 로고
    • A family of potassium channel genes related to eag in Drosophila and mammals
    • Warmke JW, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 1994;91:3438-42.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3438-3442
    • Warmke, J.W.1    Ganetzky, B.2
  • 52
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    • Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995;81:299-307.
    • (1995) Cell , vol.81 , pp. 299-307
    • Sanguinetti, M.C.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 53
    • 0037126062 scopus 로고    scopus 로고
    • Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels
    • Chen J, Seebohm G, Sanguinetri MC. Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci USA 2002;99:12461-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12461-12466
    • Chen, J.1    Seebohm, G.2    Sanguinetri, M.C.3
  • 56
    • 0037823364 scopus 로고    scopus 로고
    • Torsade de pointes due to noncardiac drugs: Most patients have easily identifiable risk factors
    • Zeltser D,Justo D, Halkin A, Prokhorov V, Heller K, Viskin S. Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors. Medicine (Baltimore) 2003;82:282-90.
    • (2003) Medicine (Baltimore) , vol.82 , pp. 282-290
    • Zeltser, D.1    Justo, D.2    Halkin, A.3    Prokhorov, V.4    Heller, K.5    Viskin, S.6
  • 57
    • 0034244378 scopus 로고    scopus 로고
    • The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs; clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology
    • Haverkamp W, et al. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs; clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology. Eur Heart J 2000;21:1216-31.
    • (2000) Eur Heart J , vol.21 , pp. 1216-1231
    • Haverkamp, W.1
  • 60
    • 0023870752 scopus 로고
    • Treatment of torsade de pointes with magnesium sulfate
    • Tzivoni D, et al. Treatment of torsade de pointes with magnesium sulfate. Circulation 1988;77:392-7.
    • (1988) Circulation , vol.77 , pp. 392-397
    • Tzivoni, D.1
  • 61
    • 0035686196 scopus 로고    scopus 로고
    • Tricyclic antidepressant overdose: A review
    • Kerr GW, McGuffie AC, Wilkie S. Tricyclic antidepressant overdose: a review. Emerg Med J 2001;18:236-41.
    • (2001) Emerg Med J , vol.18 , pp. 236-241
    • Kerr, G.W.1    McGuffie, A.C.2    Wilkie, S.3
  • 62
    • 0035907032 scopus 로고    scopus 로고
    • Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome
    • Plaster NM, et al. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 2001;105:511-9.
    • (2001) Cell , vol.105 , pp. 511-519
    • Plaster, N.M.1


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