(Z)- and (E)-[2-fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: Synthesis and antiviral activity

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6964-6972

  Zhou, Shaoman ^a   Kern, Earl R ^b   Gullen, Elizabeth ^c   Cheng, Yung Chi ^c   Drach, John C ^d   Matsumi, Shintaro ^e,f   Mitsuya, Hiroaki ^e,f   Zemlicka, Jiri ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[(2 FLUORO 2 HYDROXYMETHYL)CYCLOPROPYLIDENE]METHYL]CYTOSINE; 1 [[(2 FLUORO 2 HYDROXYMETHYL)CYCLOPROPYLIDENE]METHYL]THYMINE; 9 [[2 FLUORO 2 (HYDROXYMETHYL)CYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2 FLUORO 2 (HYDROXYMETHYL)CYCLOPROPYLIDENE]METHYL]GUANINE; [2 FLUORO 2 (HYDROXYMETHYL)CYCLOPROPYLIDENE]METHYLPURINE; [2 FLUORO 2 (HYDROXYMETHYL)CYCLOPROPYLIDENE]METHYLPYRIMIDINE; ADENOSINE DEAMINASE; ANTIVIRUS AGENT; CYCLOPROPANE DERIVATIVE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DAUDI CELL; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; FLUORINATION; HEPATITIS B VIRUS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOMER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; VARICELLA ZOSTER VIRUS; VERO CELL; VIRUS INHIBITION; VIRUS REPLICATION;

ADENOSINE DEAMINASE; ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; HERPESVIRUS 1, HUMAN; HERPESVIRUS 4, HUMAN; NUCLEOSIDES; VIRUS REPLICATION;

EID: 11144233616     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040093l     Document Type: Article

References (32)

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