(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and - guanine. New nucleoside analogues with a broad-spectrum antiviral activity

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 10-23

  Qiu, Yao Ling ^a   Ksebati, Mohamad B ^b   Ptak, Roger G ^c   Fan, Boreas Y ^c   Breitenbach, Julie M ^c   Lin, Ju Sheng ^e   Cheng, Yung Chi ^e   Kern, Earl R ^d   Drach, John C ^c   Zemlicka, Jiri ^a,f  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d University of Alabama at Birmingham   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [(2 (HYDROXYMETHYL)CYCLOPROPYLIDENE)METHYL]ADENINE; 9 [(2 (HYDROXYMETHYL)CYCLOPROPYLIDENE)METHYL]GUANINE; ACICLOVIR; ADENOSINE DEAMINASE; ADENOSINE MONOPHOSPHATE DEAMINASE; CYCLOPROPANE DERIVATIVE; GANCICLOVIR; MITOCHONDRIAL DNA; N,N DIMETHYLFORMAMIDE; NUCLEIC ACID BASE; NUCLEOSIDE ANALOG; PHOSPHORIC ACID TRIS(2,3 DIBROMOPROPYL) ESTER; SYNADENOL; SYNGUANOL; TETRAHYDROFURAN; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DAUDI CELL; DEAMINATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; EPSTEIN BARR VIRUS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; ISOMER; LEUKEMIA L 1210; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS; VERO CELL; VIRUS INHIBITION;

ADENOSINE; ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CYCLOPROPANES; GUANOSINE; HEPATITIS B VIRUS; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HIV-1; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SPECTROPHOTOMETRY, INFRARED; VERO CELLS; VIRUS REPLICATION;

EID: 15444353199     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9705723     Document Type: Article

References (53)

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2. Preliminary reports: (a) Zemlicka, J.; Qiu, Y.-L.; Kern, E. R.; Ptak, R. G.; Breitenbach, J. M.; Drach, J. C. 2-Hydroxymethyl-cyclopropylidenemethylpurines and -pyrimidines - New Nucleoside Analogues with a Broad Spectrum Antiviral Activity. 10th International Conference on Antiviral Research, Atlanta, Georgia, April 6-11, 1997. Antiviral Res. 1997, 34, A46, abstract 17. (b) Qiu, Y.-L.; Zemlicka, J.; Ksebati, M. B.; Drach, J. C. Synthesis and Isomeric Assignment of 2-Hydroxymethylcyclopropylidenepurines and -pyrimidines - New Antiviral Agents. 10th International Conference on Antiviral Research, Atlanta, Georgia, April 6-11, 1997. Antiviral Res. 1997, 34, A83, abstract 146. Qiu, Y.-L.; Ksebati; M. B.; Kern, E. R.; Drach, J, C.; Zemlicka, J. Synthesis and Antiviral Activity of Z- and E-2-Hydroxymethyl-cyclopropylidenemethylpurines and -pyrimidines. 213th National Meeting of the American Chemical Society, San Francisco, California, April 13-17, 1997, abstract MEDI 312.
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