SCOPUS 정보 검색 플랫폼

Volumn 44, Issue 23, 2001, Pages 4019-4022

Methylene-gem-difluorocyclopropane analogues of nucleosides: Synthesis, cyclopropene-methylenecyclopropane rearrangement, and biological activity

(6) Wang, R a Ksebati, M B b Corbett, T H a Kern, E R c Drach, J C d Zemlicka, J a

a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE (United States)

b WAYNE STATE UNIVERSITY (United States)

c University of Alabama at Birmingham (United States)

d UNIVERSITY OF MICHIGAN (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 9 [[1 BROMO 2 (BENZYLOXYMETHYL) 3,3 DIFLUOROCYCLOPROPYL]METHYL] 6 CHLOROPURINE; 2 AMINO 9 [[2 (BENZYLOXYMETHYL) 3,3 DIFLUOROCYCLOPROPENYL]METHYL] 6 CHLOROPURINE; 2 AMINO 9 [[2 (BENZYLOXYMETHYL) 3,3 DIFLUOROCYCLOPROPYLIDENE]METHYL] 6 CHLOROPURINE; 2 AMINO 9 [[2 (HYDROXYMETHYL) 3,3 DIFLUOROCYCLOPROPYLIDENE]METHYL] 6 CHLOROPURINE; 2 BENZYLOXYMETHYL 1 BROMO 1 BROMOMETHYL 3,3 DIFLUOROCYCLOPROPANE; 9 [[2 (BENZYLOXYMETHYL) 3,3 DIFLUOROCYCLOPROPENYL]METHYL]ADENINE; 9 [[2 (BENZYLOXYMETHYL) 3,3 DIFLUOROCYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2 (HYDROXYMETHYL) 3,3 DIFLUOROCYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2 (HYDROXYMETHYL) 3,3 DIFLUOROCYCLOPROPYLIDENE]METHYL]GUANINE; CYCLOPROPANE DERIVATIVE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HYDROLYSIS; ISOMER; NONHUMAN; REACTION ANALYSIS; THERMODYNAMICS;

ANIMALS; ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE; CYCLOPROPANES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NUCLEOSIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035829404 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm010191w Document Type: Article

Times cited : (33)

References (15)

1
- 0006505882
- Proceedings of the XIV international roundtable: Nucleosides, nucleotides and their biological applications
- September 10-14, 2000, San Francisco, CA
- (2001) Nucleosides, Nucleotides & Nucleic Acids , vol.20 , pp. 329-332

2
- 15444353199
- (Z)- and (E)-2-((Hydroxymethyl)cyclopropylidene)methyl-adenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity
- (1998) J. Med. Chem. , vol.41 , pp. 10-23
- Qiu, Y.-L.¹ Ksebati, M.B.² Ptak, R.G.³ Fan, B.Y.⁴ Breitenbach, J.M.⁵ Lin, J.-S.⁶ Cheng, Y.-C.⁷ Kern, E.R.⁸ Drach, J.C.⁹ Zemlicka, J.¹⁰

3
- 17544400595
- Synthesis and enantioselectivity of the antiviral effects of (R,Z)-, (S,Z)-Methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: Influence of heterocyclic base, type of virus and host cells
- (2000) Antiviral Chem. Chemother. , vol.11 , pp. 191-202
- Qiu, Y.-L.¹ Geiser, F.² Kira, T.³ Gullen, E.⁴ Cheng, Y.-C.⁵ Ptak, R.G.⁶ Breitenbach, J.M.⁷ Drach, J.C.⁸ Hartline, C.B.⁹ Kern, E.R.¹⁰ Zemlicka, J.¹¹

4
- 0003907264
- Wiley: New York
- (1991) Fluorine in Bioorganic Chemistry
- Welch, J.T.¹ Eswarakrishnan, S.²

5
- 0034631778
- Fluorinated nucleosides
- (2000) Carbohydr. Res. , vol.327 , pp. 87-105
- Pankiewicz, K.W.¹

6
- 0025325071
- Evaluation of the antitumor activity of gemcitabine (2′2′-difluoro-2′-deoxycytidine)
- (1990) Cancer Res. , vol.50 , pp. 4417-4422
- Hertel, L.W.¹ Boder, G.B.² Kroin, J.S.³ Rinzel, S.M.⁴ Poore, G.A.⁵ Todd, G.C.⁶ Grindey, G.B.⁷

7
- 0026032585
- 9-(Difluorophosphonoalkyl)-guanines as a new class of multisubstrate analogue inhibitors of purine nucleoside phosphorylase
- (1991) J. Am. Chem. Soc. , vol.113 , pp. 315-317
- Halazy, S.¹ Ehrhard, A.² Danzin, C.³

8
- 0032694862
- Synthesis of new nucleoside analogues comprising a geminal difluorocyclopropane moiety as potential antiviral/antitumor agents
- (1999) Nucleosides Nucleotides , vol.18 , pp. 2285-2300
- Qiu, Y.-L.¹ Zemlicka, J.²

9
- 0034629299
- Spiropentane mimics of nucleosides: Analogues of 2′-deoxyadenosine and 2′-deoxyguanosine. Synthesis of all stereoisomers, isomeric assignment, and biological activity
- (2000) J. Org. Chem. , vol.65 , pp. 1280-1290
- Guan, H.-P.¹ Ksebati, M.B.² Cheng, Y.-C.³ Drach, J.C.⁴ Kern, E.R.⁵ Zemlicka, J.⁶

10
- 0034714564
- Approaches to unsaturated analogues of nucleosides comprising four- and six-membered rings
- (2000) J. Org. Chem. , vol.65 , pp. 5177-5184
- Guan, H.-P.¹ Ksebati, M.B.² Kern, E.R.³ Zemlicka, J.⁴

11
- 0030847143
- Preparation of methylene-gem-difluorocyclopropanes and its reactivity as Michael acceptor
- (1997) Tetrahedron , vol.53 , pp. 9497-9508
- Taguchi, T.¹ Kurishita, M.² Shibuya, A.³ Aso, K.⁴

12
- 0000511262
- Cyclopropenes
- Rappoport, Z., Ed.; Wiley: New York; Part 2
- (1987) The Chemistry of the Cyclopropyl Group , pp. 1223-1339
- Halton, B.¹ Banwell, M.G.²

13
- 0000511262
- Cyclopropenes
- Rappoport, Z., Ed.; Wiley: New York; Part 2
- (1987) The Chemistry of the Cyclopropyl Group , pp. 1257-1258
- Halton, B.¹ Banwell, M.G.²

14
- 0033588075
- Preparation of methylenedifluorocyclopropanes via cyclopropyl anion promoted β-elimination
- (1999) Tetrahedron , vol.55 , pp. 10325-10340
- Shibuya, A.¹ Okada, M.² Nakamura, Y.³ Kibashi, M.⁴ Horikawa, H.⁵ Taguchi, T.⁶

15
- 0032847951
- Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin
- (1999) Invest. New Drugs , vol.17 , pp. 17-27
- Corbett, T.H.¹ Panchapor, C.² Polin, L.³ Lowichik, N.⁴ Pugh, S.⁵ White, K.⁶ Kushner, J.⁷ Meyer, J.⁸ Czarnecki, J.⁹ Chinnukroh, S.¹⁰ Edelstein, M.¹¹ LoRusso, P.¹² Heilbrun, L.¹³ Horwitz, J.P.¹⁴ Grieshaber, C.¹⁵ Perni, R.¹⁶ Wentland, M.¹⁷ Coughlin, S.¹⁸ Elenblass, S.¹⁹ Philion, R.²⁰ Rake, J.²¹ more..

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