Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants

Antiviral Research

Volumn 56, Issue 3, 2002, Pages 273-278

  Baldanti, Fausto ^a   Sarasini, Antonella ^a   Drach, John C ^b   Zemlicka, Jiri ^c   Gerna, Giuseppe ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF MICHIGAN   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

Author keywords

Foscarnet resistance; Ganciclovir resistance; HCMV drug susceptibility; HCMV UL97 phosphotransferase; Synadenol; Synguanol

Indexed keywords

FOSCARNET; GANCICLOVIR; PHOSPHOTRANSFERASE; SYNADENOL; SYNGUANOL;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BIOSYNTHESIS; CASE REPORT; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENZYME SPECIFICITY; HUMAN; HUMAN CYTOMEGALOVIRUS; IC 50; IMMUNE DEFICIENCY; ISOMER; PHOSPHORYLATION; PRIORITY JOURNAL; TREATMENT FAILURE; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS REPLICATION; VIRUS STRAIN;

ADENINE; ANTIVIRAL AGENTS; CYCLOPROPANES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG RESISTANCE, VIRAL; FOSCARNET; GANCICLOVIR; GUANINE; HUMANS; IMMUNOCOMPROMISED HOST; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0036888658     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00129-8     Document Type: Article

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