A new efficient synthesis of antiviral methylenecyclopropane analogs of purine nucleosides

Synthesis

Volumn , Issue 10, 1998, Pages 1447-1452

  Qiu, Yao Ling ^a   Zemlicka, Jiri ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alkylation elimination; Antiviral agents; Halogen exchange; Methylenecyclopropane analogs of purine nucleosides; Synadenol

Indexed keywords

2 AMINO 6 (CYCLOPROPYLAMINO)PURINE; ANTIVIRUS AGENT; SYNADENOL; SYNGUANOL; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 0031756538     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-2163     Document Type: Article

References (6)

1. Qiu, Y.-L.; Ksebati, M. B.; Ptak, R. G.; Fan, B. Y.; Breitenbach, J. M.; Lin, J.-S.; Cheng, Y.-C.; Kern, E. R.; Drach, J. C.; Zemlicka, J. J. Med. Chem. 1998, 41, 10.
2. Qiu, Y.-L.; Ptak, R. G.; Breitenbach, J. M.; Lin, J.-S.; Cheng, Y.-C.; Kern, E. R.; Drach, J. C.; Zemlicka, J. Antiviral Chem. Chemother. in press.
3. Cheng, C.; Shimo, T.; Somekawa, K.; Kawaminami, M. Tetrahedron Lett. 1997, 38, 9005.
4. Marchand, A. P.; Devasagayaraj, A. J. Org. Chem. 1997, 62, 4434.
5. Baird, M. S.; Hussain, H. H.; Nethercott, W. J. Chem. Soc. Perkin Trans. 1 1986, 1845.
6. Schroder, G. Chem. Ber. 1963, 96, 3178.