Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help

Journal of Immunology

Volumn 160, Issue 4, 1998, Pages 1694-1700

  Macaulay, Anne E ^a   DeKruyff, Rosemarie H ^a   Umetsu, Dale T ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; HUMORAL IMMUNE DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODY FORMATION; ANTIGEN-PRESENTING CELLS; ANTIGENS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CYTOKINES; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTERLEUKIN-4; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0032519450     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ron, Y., and J. Sprent. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138:2848.
2. Hayglass, K. T., S. J. Naides, C. J. Scott, B. Benacerraf, and M. S. Sy. 1986. T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo. J. Immunol. 136:823.
3. Janeway, C. J., J. Ron, and M. E. Katz. 1987. The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J. Immunol. 138:1051.
4. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423.
5. H locus. Int. Immunol. 5:647.
6. + T cells to protein antigens in vivo. J. Immunol. 155:3734.
7. Vella, A. T., M. T. Scherer, L. Schultz, J. W. Kappler, and P. Marrack. 1996. B cells are not essential for peripheral T-cell tolerance. Proc. Natl. Acad. Sci. USA 93:951.
8. Liu, Y., Y. Wu, L. Ramarathinam, Y. Guo, D. Huszar, M. Trounstine, and M. Zhao. 1995. Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response. Int. Immunol. 7:1353.
9. Epstein, M. M., R. F. Di, D. Jankovic, A. Sher, and P. Matzinger. 1995. Successful T cell priming in B cell-deficient mice. J. Exp. Med. 182:915.
10. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, G. S. Smith, R. A. Brink, B. H. Pritchard, J. S. Wotherspoon, R. H. Loblay, K. Raphael, R. J. Trent, and A. Basten. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
11. + T cells to produce IL-4. J. Immunol. 158:4171.
12. Shlomchik, M. J., M. P. Madaio, D. Ni, M. Trounstein, and D. Huszar. 1994. The role of B cells in lpr/lpr-induced autoimmunity. J. Exp. Med. 180:1295.
13. Rizzo, L. V., R. H. DeKruyff, and D. T. Umetsu. 1992. Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones. J. Immunol. 148:3733.
14. + T cells. I. Influence of antigen concentration and antigen-presenting cell type. J. Immunol. 149:3468.
15. Mage, M. G., L. L. McHugh, and T. L. Rothstein. 1977. Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin. J. Immunol. Methods 15:47.
16. + T cells. J. Clin. Immunol. 15:105.
17. + T cells requires repeated antigenic stimulation. Cell. Immunol. 152:18.
18. Dekruyff, R. H., H. Cantor, and M. E. Dorf. 1986. Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells. J. Immunol. 136:446.
19. Coffman, R. L., D. A. Lebman, and P. Rothman. 1993. Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54:229.
20. + T cell functions. J. Exp. Med. 183:2209.
21. Kitamura, D., and K. Rajewsky. 1992. Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion [see comments]. Nature 356:154.
22. + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J. Immunol. 156:3133.
23. Heath, A. W., W. W. Wu, and M. C. Howard. 1994. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur. J. Immunol. 24:1828.
24. van Essen, D., H. Kikutani, and D. Gray. 1995. CD40 ligand-transduced costimulation of T cells in the development of helper function. Nature 378:620.
25. + T lymphocytes. J. Immunol. 152:1523.
26. Stockinger, B., T. Zal, A. Zal, and D. Gray. 1996. B cells solicit their own help from T cells. J. Exp. Med. 183:891.
27. Hasbold, J., L. C. Johnson, C. J. Atkins, E. A. Clark, and G. G. Klaus. 1994. Properties of mouse CD40: cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies. Eur. J. Immunol. 24:1835.
28. Gray, D., K. Siepmann, and G. Wohlleben. 1994. CD40 ligation in B cell activation, isotype switching and memory development. Semin. Immunol. 6:303.
29. Kennedy, M. K., K. M. Mohler, K. D. Shanebeck, P. R. Baum, K. S. Picha, E. C. Otten, C. J. Janeway, and K. H. Grabstein. 1994. Induction of B cell costimulatory function by recombinant murine CD40 ligand. Eur. J. Immunol. 24:116.
30. Roy, M., A. Aruffo, J. Ledbetter, P. Linsley, M. Kehry, and R. Noelle. 1995. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur. J. Immunol. 25:596.
31. Guo, Y., Y. Wu, S. Shinde, M. S. Sy, A. Aruffo, and Y. Liu. 1996. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med. 184:955.
32. Wu, Y., J. Xu, S. Shinde, I. Grewal, T. Henderson, R. A. Flavell, and Y. Liu. 1995. Rapid induction of a novel costimulatory activity on B cells by CD40 ligand. Curr. Biol. 5:1303.