Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing radiation

Cancer Research

Volumn 64, Issue 24, 2004, Pages 9035-9040

  Syljuåsen, Randi G ^a   Sørensen, Claus Storgaard ^a,b   Nylandsted, Jesper ^a   Lukas, Claudia ^a   Lukas, Jiri ^a   Bartek, Jiri ^a,c  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Institute of Cancer Biology   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CEP 3891; CHECKPOINT KINASE 1; GREEN FLUORESCENT PROTEIN; HISTONE H2B; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL KILLING; CELL NUCLEUS; CHROMOSOME SEGREGATION; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; MICROSCOPY; MITOSIS; PRIORITY JOURNAL;

APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; G2 PHASE; HUMANS; MITOSIS; OSTEOSARCOMA; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RADIATION-SENSITIZING AGENTS; S PHASE;

EID: 10844237358     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2434     Document Type: Article

References (44)

1. 2 arrests through Cdc25A degradation in response to DNA-damaging agents. J Biol Chem 2003;278:21767-73.
2. Gatei M, Sloper K, Sorensen C, et al. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem 2003;278:14806-11.
3. Sorensen CS, Syljuasen RG, Falck J, et al. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 2003;3:247-58.
4. 2 checkpoints. Proc Natl Acad Sci USA 2002;99:14795-800.
5. Heffernan TP, Simpson DA, Frank AR, et al. An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol Cell Biol 2002;22:8552-61.
6. Feijoo C, Hall-Jackson C, Wu R, et al. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol 2001;154:913-23.
7. 1/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Mol Cell Biol 1999;19:6183-94.
8. Sanchez Y, Wong C, Thoma RS, et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (Wash DC) 1997;277:1497-501.
9. Kumagai A, Dunphy WG. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 1991;64:903-14.
10. 2/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J 2002;21:5911-20.
11. Chen MS, Hurov J, White LS, Woodford-Thomas T, Piwnica-Worms H. Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol 2001;21:3853-61.
12. Dison H, Norbury CJ. Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function. Cell Cycle 2002;1:362-8.
13. Yao SL, Akhtar AJ, McKenna KA, et al. Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nat Med 1996;2:1140-3.
14. 2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 2001;20:7453-63.
15. Sarkaria JN, Busby EC, Tibbetts RS, et al. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 1999;59:4375-82.
16. 2 arrest. Radiat Res 1984;97:178-85,
17. Graves PR, Yu L, Schwarz JK, et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem 2000;275:5600-5.
18. Iliakis G, Wang Y, Guan J, Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 2003;22:5834-47.
19. 2/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002;22:1049-59.
20. Wang H, Boecker W, Wang X, et al. Caffeine inhibits homology-directed repair of 1-SceI-induced DNA double-strand breaks. Oncogene 2004;23:824-34.
21. 2 delay causes HeLa cells to undergo apoptosis instead of mitotic death. Int J Radiat Biol 1996;69:575-84.
22. Puck TT, Marcus PI. Action of x-rays on mammalian cells. J Exp Med 1956;103:653-66.
23. Ianzini F, Mackey MA. Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells. Int J Radiat Biol 1997;72:409-21.
24. Muller WU, Schlusen I, Streffer C. Direct evidence that radiation induced micronuclei of early embryos require a mitosis for expression. Radiat Environ Biophys 1991;30:117-22.
25. Jonathan EC, Bernhard EJ, McKenna WG. How does radiation kill cells? Curr Opin Chem Biol 1999;3:77-83.
26. Dewey WC, Ling CC, Meyn RE. Radiation-induced apoptosis: relevance to radiotherapy. Int J Radiat Oncol Biol Phys 1995;33:781-96.
27. Forrester HB, Albright N, Ling CC, Dewey WC. Computerized video time-lapse analysis of apoptosis of REC:Myc cells X-irradiated in different phases of the cell cycle. Radiat Res 2000;154:625-39.
28. Dikomey E, Borgmann K, Brammer I, Kasten-Pisula U. Molecular mechanisms of individual radiosensitivity studied in normal diploid human fibroblasts. Toxicology 2003;193:125-35.
29. Fehrenbacher N, Gyrd-Hansen M, Poulsen B, et al. Sensitization to the lysosomal cell death pathway upon immortalization and transformation. Cancer Res 2004;64:5301-10.
30. Sato N, Mizumoto K, Nakamura M, et al. A possible role for centrosome overduplication in radiation-induced cell death. Oncogene 2000;19:5281-90.
31. Kanda T, Sullivan KF, Wahl GM. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol 1998;8:377-85.
32. Earnshaw WC. Nuclear changes in apoptosis. Curr Opin Cell Biol 1995;7:337-43.
33. Galgoczy DJ, Toczyski DP. Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast. Mol Cell Biol 2001;21:1710-8.
34. Yoo HY, Kumagai A, Shevchenko A, Dunphy WG. Adaptation of a DNA replication checkpoint response depends upon inactivation of claspin by the Polo-like kinase. Cell 2004;117:575-88.
35. Chu K, Leonhardt EA, Trinh M, et al. Computerized video time-lapse (CVTL) analysis of cell, death kinetics in human bladder carcinoma cells (EJ30) X-irradiated in different phases of the cell cycle. Radiat Res 2002;158:667-77.
36. Den Elzen N, Kosoy A, Christopoulos H, O'Connell MJ. Resisting arrest: recovery from checkpoint arrest through dephosphorylation of Chk1 by PPI. Cell Cycle 2004;3:529-33.
37. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003;3:155-68.
38. Ford MD, Martin L, Lavin MF. The effects of ionizing radiation on cell cycle progression in ataxia telangiectasia. Mutat Res 1984;125:115-22.
39. Beamish H, Lavin MF. Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay. Int J Radiat Biol 1994;65:175-84.
40. Hlatky L, Sachs RK, Vazquez M, Cornforth MN. Radiation-induced chromosome aberrations: insights gained from biophysical modeling. Bioessays 2002;24:714-23.
41. Forrester HB, Vidair CA, Albright N, Ling CC, Dewey WC. Using computerized video time lapse for quantifying cell death of X-irradiated rat embryo cells transfected with c-myc or c-Ha-ras. Cancer Res 1999;59:931-9.
42. Monks A, Harris ED, Vaigro-Wolff A, et al. UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines. Investig New Drugs 2000;18:95-107.
43. 2 checkpoint function in cancer cells with disrupted p53. J Natl Cancer Inst (Bethesda) 1996;88:956-65.
44. 2 checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res 2001;61:5843-9.