Blockade of Receptor for Advanced Glycation End Product (RAGE) Attenuates Ischemia and Reperfusion Injury to the Liver in Mice

Hepatology

Volumn 39, Issue 2, 2004, Pages 422-432

  Zeng, Shan ^a   Feirt, Nikki ^a   Goldstein, Michael ^a   Guarrera, James ^a   Ippagunta, Nikalesh ^a   Ekong, Udeme ^a   Dun, Hao ^a   Lu, Yan ^a   Qu, Wu ^a   Schmidt, Ann Marie ^a   Emond, Jean C ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; AUTACOID; CYCLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN RECEPTOR; LIGAND; PEPTIDE FRAGMENT; PROTEIN P42; PROTEIN P44; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; GLYCATION; HEPATITIS; HOMEOSTASIS; IMMUNOLOGY; LIVER INJURY; LIVER ISCHEMIA; LIVER NECROSIS; LIVER PROTECTION; LIVER REGENERATION; LIVER RESECTION; LIVER TRANSPLANTATION; MALE; METABOLISM; MORTALITY; MOUSE; MOUSE STRAIN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BLOCKING; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SURVIVAL RATE;

ANIMALS; CELL DEATH; HEPATITIS; HOMEOSTASIS; INFLAMMATION MEDIATORS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PEPTIDE FRAGMENTS; RECEPTORS, IMMUNOLOGIC; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION FACTOR AP-1;

EID: 10744229479     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20045     Document Type: Article

References (42)

1. Hernandez LA, Grishman MB, Twohig B, Arfors KE, Harlan JM, Granger DN. Role of neutrophils in ischemia-reperfusion -induced microvascular injury. Am J Physiol 1987;253:699-703.
2. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol 2003;284:G15-G26.
3. Suzuki S, Toledo-Pereyra LH, Rodriquez FJ. Role of neutrophils during the first 24 hrs after liver ischemia and reperfusion injury. Transplant Proc 1994;26:3695-3700.
4. Jaeschke H, Bautista AP, Spolaries Z, Spitzer JJ. Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic Res Commun 1991;15:277-284.
5. Rymsa B, Wang JF, deGroot H. O2-release by activated Kupffer cells upon hypoxia-reoxygenation. Am J Physiol 1991;261:G602-G607.
6. Zwacka RM, Zhang Y, Halldorson J, Schlossberg H, Dudus L, Engelhardt JF. CD4+ t lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. J Clin Invest 1997;100:279-289.
7. Kubes P. The role of adhesion molecules and nitric oxide in intestinal and hepatic ischemia/reperfusion. Hepato-Gastroenterol 1999;46:1458-1463.
8. Liu P, Xu B, Hock CE, Nagele R, Sun FF, Wong PYK. NO modulates P-selectin and ICAM-1 mRNA expression and hemodynamic alterations in hepatic I/R. Am J Physiol 1998;44:H2191-H2198.
9. Yadav SS, Howell DN, Steeber DA, Harland RC, Tedder T, Clavien PA. P-selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver. HEPATOLOGY 1999;29:1494-1502.
10. Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000;118:183-191.
11. Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation 1999;67:1099-1105.
12. Daemen M, Veer C, Denecker G, Heemskerk VH, Wolfs T, Clauss M, Vandenabeele P, et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 1999;104:541-549.
13. Gujral JS, Bucci TJ, Farhood A, Jaeschke H. Mechanisms of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis? HEPATOLOGY 2001;33:397-405.
14. Crenesse D, Laurens M, Gugenheim J, Heurteaux C, Cursio R, Rossi B, et al. Intermittent ischemia reduces warm hypoxia-reoxygenation induced JNK1/SAPK1 activation in rat hepatocytes. HEPATOLOGY 2001;34:973-978.
15. Kato A, Yoshidome H, Edwards MJ, Lentsch AB. Regulation of liver inflammatory injury by signal transducer and activator of transcription-6. Am J Pathol 2000;157:297-302.
16. Essani NA, Fisher MA, Jaeschke H. Inhibition of NF-κB by dimethyl sulfoxide correlates with suppression of TNF-alpha formation, reduced ICAM-1 gene transcription, and protection against endotoxin-induced liver injury. Shock 1997;7:90-96.
17. Zwacka RM, Zhou W, Zhang Y, Darby CJ, Dudus L, Halldorson J, Oberley L, et al. Redox gene therapy for ischemia-reperfusion injury of the liver reduces AP1 and NF-κB activation. Nat Med 1998;4:698-704.
18. Barkett M, Gilmore T. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 1999;18:6910-6924.
19. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, et al. NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998;101:802-811.
20. Schmidt AM, Yan SD, Yan SF, Stern DM. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 2001;108:949-955.
21. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan SD, Hofmann M, et al. Nε (carboxymethyl)lysine modifications of proteins are ligands for RAGE that activate cell signalling pathways and modulate gene expression. J Biol Chem 1999;274:31740-31749.
22. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999;97:889-901.
23. Hofmann MA, Drury S, Hudson BI, Gleason MR, Qu W, Lu Y, Lalla E, et al. RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response. Genes Immunity 2002;3:123-135.
24. Goldblum SE, W KM, Jay M. Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits. J Appl Physiol 1985;59:1978-1985.
25. Smedsrod B, Melkko JM, Araki N, Sano H, Horiuchi S. Advanced glycation endproducts are eliminated by scavenger receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochem J 1997;322:567-573.
26. Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003;3:51-62.
27. Lau AH, Thomson AW. Dendritic cells and immune regulation in the liver. Gut 2003;52:307-314.
28. Debonera F, Aldeguer X, Shen X, Gelman AE, Gao F, Que X, Greenbaum LE, et al. Activation of interleukin-6/STAT3 and liver regeneration following transplantation. J Surg Res 2001;96:289-295.
29. Koyama H, Olson NE, Dastvan FF, Reidy MA. Cell replication in the arterial wall: activation of signaling pathways following in vivo injury. Circ Res 1998;82:713-721.
30. Ono K, Han J. The p38 signal transduction pathway: activation and function. Cell Signal 2000;12:1-13.
31. Gilot D, Loyer P, Corla A, Glaise D, Lagadic-Gossmann D, Atfi A, Morel F, et al. Liver protection from apoptosis required both blockade of initiator caspase activities and inhibition of ASK1/JNK pathways via glutathione S-transferase regulation. J Biol Chem 2002;277:49220-49229.
32. Crenesse D, Laurens M, Gugenheim J, Heurteaux C, Cursio R, Rossi B, Schmid-Alliana A. Intermittent ischemia reduces warm hypoxia-reoxygenation-induced JNK(1)/SAPK(1) activation and apoptosis in rat hepatocytes. HEPATOLOGY 2001;34:972-978.
33. Liedtke C, Plumpe J, Kubicka S, Bradham CA, Manns MP, Brenner DA, et al. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. HEPATOLOGY 2002;36:315-325.
34. Jaeschke H, Fisher MA, Lawson JA, Simmons CA, Farhood A, Jones DA. Activation of caspase-3 (CPP32)-like proteases is essential for TNF-alpha induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J Immunol 1998;160:3480-3486.
35. Yamada Y, Kirillova I, Peschon JJ, Fausto, N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking rype 1 tumor necrosis factor receptor. Proc Natl Acad Sci U S A 1997;94:1441-1446.
36. Shinozuka H, Kobo Y, Karyal SL, Coni P, Ledda-Columbano GM, Columbano A, Nakamura T. Roles of hepatocyte growth factor and tumor necrosis factor alpha on liver cell proliferation induced in rats by lead nitrate. Lab Invest 1994;71:35-41.
37. Webber EM, Bruix J, Pierce RH, Fausto N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. HEPATOLOGY 1998;28:1226-1234.
38. Zwacka RM, Zhang Y, Zhou W, Haldorson J, Engelhardt JF. Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor-κB independently of IκB degradation. HEPATOLOGY 1998;28:1022-1030.
39. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethaliry and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376:167-170.
40. Tanaka M, Fuentes ME, Yamaguchi K, Durnin MH, Dalrymple SA, Hardy KL, Goeddel DV. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-beta-deficient mice. Immunity 1999;10:421-429.
41. Yao J, Mackman N, Edgington TS, Fan ST. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by egr-1, c-Jun, and NF-κB transcription factors. J Biol Chem 1997;272:17795-17801.
42. Yan SS, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, et al. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med 2003;9:287-293.