Activation of interleukin-6/STAT3 and liver regeneration following transplantation

Journal of Surgical Research

Volumn 96, Issue 2, 2001, Pages 289-295

  Debonera, Fotini ^a   Aldeguer, Xavier ^a   Shen, Xiuda ^a   Gelman, Andrew E ^a   Gao, Feng ^a   Que, Xingyi ^a   Greenbaum, Linda E ^a   Furth, Emma E ^a   Taub, Rebecca ^a   Olthoff, Kim M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Interleukin 6; Ischemia reperfusion; Liver regeneration; Liver transplantation; STAT3

Indexed keywords

INTERLEUKIN 6; LIVER PROTEIN; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; STAT3 PROTEIN; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL DIVISION; CONTROLLED STUDY; CRYOPRESERVATION; CYTOKINE PRODUCTION; DNA REPLICATION; GENE EXPRESSION REGULATION; LIVER ISCHEMIA; LIVER PRESERVATION; LIVER REGENERATION; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REPERFUSION;

EID: 0035747119     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2001.6086     Document Type: Article

References (37)

1. Selecting the donor liver: Risk factors for poor function after orthotopic liver transplantation
2. Risk factors for primary dysfunction after liver transplantation: A multivariate analysis
3. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury
4. Emerging immunologic basis of reperfusion injury
5. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers
6. Preservation and reperfusion injuries in liver allografts
7. Reperfusion injury to donor livers stored for transplantation
8. STATs and gene regulation
9. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
10. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
11. STAT3 is required for the gp130-mediated full activation of the c-myc gene
12. Rapid activation of the Stat3 transcription complex in liver regeneration
13. Review: Regulation of liver regeneration by pro-inflammatory cytokines
14. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
15. Transcriptional regulatory signals define cytokine dependent and independent pathways in liver regeneration
16. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
17. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
18. Orthotopic liver transplantation in the rat: Technique using cuff for portal vein anastomosis and biliary drainage
19. Rapid induction in regenerating liver of RL/IF-1 (an IkB that inhibits NF-kB, RelB-p50, and c-Rel-p50) and PHF, a novel kB site-binding complex
20. The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver
21. Interleukin 6 and liver regeneration
22. The induction of immediate early genes in postischemic and transplanted livers in rats
23. Continuous c-fos expression precedes programmed cell death in vivo
24. Expression of c-fos and c-jun during hepatocellular remodeling following ischemia/reperfusion in mouse liver
25. Liver regeneration
26. Liver regeneration
27. Liver regeneration following hepatic injury
28. STATs: Signal transducers and activators of transcription
29. Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway
30. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type l tumor necrosis factor receptor
31. Reperfusion after liver transplantion in rats differentially activates the mitogen-activated protein kinases
32. Activation of nuclear factor-kB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells
33. Role of tumor necrosis factor-a in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat
34. Interleukin 1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury
35. Ischemia/reperfusion injury in the liver of BALB/C mice activates AP-1 and nuclear factor kB independently of IkB degradation
36. Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12cell (E2) line
37. Activation of the JAK-STAT pathway by reactive oxygen species