Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 14, 2000, Pages 1535-1538

  Wrobel, Jay ^a   Li, Zenan ^a   Sredy, Janet ^a   Sawicki, Diane R ^a   Seestaller, Laura ^a   Sullivan, Donald ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORENE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL MODEL; ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; EXPERIMENTAL DIABETES MELLITUS; INSULIN RESISTANCE; MOUSE; NONHUMAN; PARTIAL DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BENZOFURANS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; INDICATORS AND REAGENTS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOPHENES;

EID: 0034679837     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00278-X     Document Type: Article

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