HIV-1 Nef Mimics an Integrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane

Molecular Cell

Volumn 13, Issue 2, 2004, Pages 179-190

  Witte, Vanessa ^a   Laffert, Bernd ^a   Rosorius, Olaf ^a   Lischka, Peter ^a   Blume, Katja ^a   Galler, Gunther ^b   Stilper, Andrea ^a   Willbold, Dieter ^c   D'Aloja, Paola ^a   Sixt, Michael ^d   Kolanus, Johanna ^e   Ott, Melanie ^f   Kolanus, Waldemar ^e   Schuler, Gerold ^a   Baur, Andreas S ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d Institute for Experimental Pathology   (Sweden)

^e UNIVERSITY OF BONN   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN RECEPTOR; NEF PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION TERMINATION FACTOR EED; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; VIRUS TRANSCRIPTION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 10744228109     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(04)00004-8     Document Type: Article

References (41)

1. Arold S.T., Baur A.S. Dynamic Nef and Nef dynamics. how structure could explain the complex activities of this small HIV protein Trends Biochem. Sci. 26:2001;356-363.
2. Baur A.S., Sawai E.T., Dazin P., Fantl W., Cheng-Mayer C., Peterlin B.M. HIV-1 Nef leads to inhibition or activation of T cell depending on its intracellular localization. Immunity. 1:1994;373-384.
3. Baur A.S., Sass G., Laffert B., Willbold D., Cheng-Mayer C., Peterlin B.M. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity. 6:1997;283-291.
4. Cao R., Wang L., Wang H., Xia L., Erdjument-Bromage H., Tempst P., Jones R.S., Zhang Y. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science. 298:2002;1039-1043.
5. Czermin B., Melfi R., McCabe D., Seitz V., Imhof A., Pirrotta V. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell. 111:2002;185-196.
6. Denisenko O.N., Bomsztyk K. The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity. Mol. Cell. Biol. 17:1997;4707-4717.
7. Doms R.W., Trono D. The plasma membrane as a combat zone in the HIV battlefield. Genes Dev. 14:2000;2677-2688.
8. El Kharroubi A., Piras G., Zensen R., Martin M.A. Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. Mol. Cell. Biol. 18:1998;2535-2544.
9. Fackler O.T., Baur A.S. Live and let die. Nef functions beyond HIV replication Immunity. 16:2002;493-497.
10. Fackler O.T., Wolf D., Weber H.O., Laffert B., D'Aloja P., Schuler-Thurner B., Geffin R., Saksela K., Geyer M., Peterlin B.M.et al. A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells. Curr. Biol. 11:2001;1294-1299.
11. Fagerholm S., Hilden T.J., Gahmberg C.G. Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes. Eur. J. Immunol. 32:2002;1670-1678.
12. Feigelson S.W., Grabovsky V., Winter E., Chen L.L., Pepinsky R.B., Yednock T., Yablonski D., Lobb R., Alon R. The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin. J. Biol. Chem. 276:2001;13891-13901.
13. Hanna Z., Kay D.G., Rebai N., Guimond A., Jothy S., Jolicoeur P. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell. 95:1998;163-175.
14. He G., Margolis D.M. Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat. Mol. Cell. Biol. 22:2002;2965-2973.
15. Hynes R.O. Integrins. bidirectional, allosteric signaling machines Cell. 110:2002;673-687.
16. Jordan A., Defechereux P., Verdin E. The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. EMBO J. 20:2001;1726-1738.
17. Kestler H.W. III, Ringler D.J., Mori K., Panicali D.L., Sehgal P.K., Daniel M.D., Desrosiers R.C. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell. 65:1991;651-662.
18. Kolanus W., Nagel W., Schiller B., Zeitlmann L., Godar S., Stockinger H., Seed B. αLβ2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell. 86:1996;233-242.
19. Lischka P., Rosorius O., Trommer E., Stamminger T. A novel transferable nuclear export signal mediates CRM1-independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69. EMBO J. 20:2001;7271-7283.
20. Lu X., Yu H., Liu S.H., Brodsky F.M., Peterlin B.M. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity. 8:1998;647-656.
21. Macara I.G. Transport into and out of the nucleus. Microbiol. Mol. Biol. Rev. 65:2001;570-594.
22. Miller M.D., Warmerdam M.T., Gaston I., Greene W.C., Feinberg M.B. The human immunodeficiency virus-1 nef gene product. a positive factor for viral infection and replication in primary lymphocytes and macrophages J. Exp. Med. 179:1994;101-113.
23. Ott M., Schnolzer M., Garnica J., Fischle W., Emiliani S., Rackwitz H.R., Verdin E. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Curr. Biol. 9:1999;1489-1492.
24. Pirrotta V. Polycombing the genome. PcG, trxG, and chromatin silencing Cell. 93:1998;333-336.
25. Raaphorst F.M., Otte A.P., Meijer C.J. Polycomb-group genes as regulators of mammalian lymphopoiesis. Trends Immunol. 22:2001;682-690.
26. Rietzler M., Bittner M., Kolanus W., Schuster A., Holzmann B. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. J. Biol. Chem. 273:1998;27459-27466.
27. Rost B., Sander C. Prediction of protein secondary structure at better than 70% accuracy. J. Mol. Biol. 232:1993;584-599.
28. Roth J., Dobbelstein M. Export of hepatitis B virus RNA on a Rev-like pathway. inhibition by the regenerating liver inhibitory factor IkappaB alpha J. Virol. 71:1997;8933-8939.
29. Satijn D.P., Hamer K.M., den Blaauwen J., Otte A.P. The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. Mol. Cell. Biol. 21:2001;1360-1369.
30. Schumacher A., Magnuson T. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13:1997;167-170.
31. Schumacher A., Faust C., Magnuson T. Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature. 384:1996;648.
32. Schwartz M.A., Ginsberg M.H. Networks and crosstalk. integrin signalling spreads Nat. Cell Biol. 4:2002;E65-E68.
33. Sewalt R.G., van der Vlag J., Gunster M.J., Hamer K.M., den Blaauwen J.L., Satijn D.P., Hendrix T., van Driel R., Otte A.P. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol. Cell. Biol. 18:1998;3586-3595.
34. Simmons A., Aluvihare V., McMichael A. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity. 14:2001;763-777.
35. Smith T.F., Gaitatzes C., Saxena K., Neer E.J. The WD repeat. a common architecture for diverse functions Trends Biochem. Sci. 24:1999;181-185.
36. Spina C.A., Kwoh T.J., Chowers M.Y., Guatelli J.C., Richman D.D. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med. 179:1994;115-123.
37. Takagi J., Petre B.M., Walz T., Springer T.A. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 110:2002;599-611.
38. van der Vlag J., Otte A.P. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat. Genet. 23:1999;474-478.
39. Van Lint C., Emiliani S., Ott M., Verdin E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15:1996;1112-1120.
40. van Lohuizen M., Tijms M., Voncken J.W., Schumacher A., Magnuson T., Wientjens E. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed. indication for separate Pc-G complexes Mol. Cell. Biol. 18:1998;3572-3579.
41. Wolf D., Witte V., Laffert B., Blume K., Stromer E., Trapp S., D'Aloja P., Schurmann A., Baur A.S. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat. Med. 7:2001;1217-1224.