The Pyridinyl-6 position of WAY-100635 as a site for radiofluorination - Effect on 5-HT1A receptor radioligand behavior in vivo

Molecular Imaging and Biology

Volumn 6, Issue 1, 2004, Pages 17-26

  McCarron, Julie A ^a   Pike, Victor W ^a   Halldin, Christer ^b   Sandell, Johan ^b   Sóvágó, Judit ^b   Gulyas, Balàsz ^b   Cselényi, Zsolt ^b   Wikström, Hakan V ^c   Marchais Oberwinkler, Sandrine ^c   Nowicki, Bartek ^c   Dollé, Frédéric ^d   Farde, Lars ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d DIF   (France)

Author keywords

5 HT1A receptor; 18F 6FPWAY; Brain; Fluorine 18; Monkey; PET; Radioligand

Indexed keywords

BROMINE DERIVATIVE; FLUORINE DERIVATIVE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 FLUOROPYRIDYL)CYCLOHEXANECARBOXAMIDE F 18; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PYRIDINE DERIVATIVE; RADIOLIGAND; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BRAIN REGION; CEREBELLUM; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IMAGE ANALYSIS; IN VIVO STUDY; MALE; METABOLITE; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY;

AMINOPYRIDINES; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; MACACA FASCICULARIS; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDINES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN ANTAGONISTS; TOMOGRAPHY, EMISSION-COMPUTED;

MACACA FASCICULARIS;

EID: 10744227898     PISSN: 15361632     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mibio.2003.12.001     Document Type: Article

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