The potential of the β-Microprobe, an intracerebral radiosensitive probe, to monitor the [18F]MPPF binding in the rat dorsal raphe nucleus

European Journal of Nuclear Medicine

Volumn 29, Issue 9, 2002, Pages 1237-1247

  Zimmer, L ^a,b,c,d   Pain, F ^a,b,c,d   Mauger, G ^a,b,c,d   Plenevaux, A ^a,b,c,d   Le Bars, D ^a,b,c,d   Mastrippolito, R ^a,b,c,d   Pujol, J ^a,b,c,d   Renaud, B ^a,b,c,d   Laniece P ^a,b,c,d  

^a CERMEP IMAGERIE DU VIVANT   (France)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

5 HT1A receptors; Raphe dorsalis nucleus; Small animal; 18F MPPF; Microprobe

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; TRACER;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BETA MICROPROBE; BINDING KINETICS; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVICE; DORSAL RAPHE NUCLEUS; DRUG BINDING; MALE; MICROANALYSIS; MICRODIALYSIS; MONTE CARLO METHOD; NONHUMAN; RAT; VALIDATION PROCESS;

EID: 0036372407     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-002-0866-6     Document Type: Article

References (51)

1. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET)
2. Design features and performance of a PET system for animal research
3. Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation
4. Performance evaluation of microPET: A high-resolution lutetium oxyorthosilicate PET scanner for animal imaging
5. Radio-imaging in small animals
6. The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease
7. Molecular imaging of small animals with dedicated PET tomographs
8. Sic, an intracerebral radiosensitive probe for in vivo neuropharmacology investigations in small laboratory animals: Theoretical considerations and physical characteristics
9. 11C]raclopride
10. 18F-MPPF in the rat hippocampus: Kinetic Beta measurements combined with microdialysis
11. The serotonin innervation of the cerebral cortex in the rat - An immunohistochemical analysis
12. Distribution of serotonin receptors
13. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: Role of somatodendritic autoreceptors
14. 18F]MPPF, a fluoro analog of WAY-100635 for visualization of 5-HT1A receptors
15. 18F]MPPF), a new serotonin 5-HT1A antagonist for positron emission tomography: An in vivo study in rats
16. 18F]-MPPF using a coincidence synthesizer
17. 18F]MPPF, a fluoro analog of WAY-100635
18. Estimation of in vivo neurotransmitter release by brain microdialysis: The issue of validity
19. Treating electron transport in MCNP
20. Calculation of positron range and its effect on the fundamental limit of positron emission tomography system
21. Possible implication of 5-HT1A function for the etiology and treatment of depression
22. Serotonin receptors: Clinical implications
23. 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates
24. 5-HT receptors: Past, present and future
25. Serotonin receptors: Subtypes, functional responses and therapeutic relevance
26. Serotonin receptors in the human brain. III. Autoradiographic mapping of serotonin-1 receptors
27. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
28. Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype
29. A review of central 5-HT receptors and their function
30. Control of dorsal raphe 5-HT function by multiple 5-HT(1) autoreceptors: Parallel purposes or pointless plurality?
31. Autoregulation of serotonin neurons: Role in antidepressant drug action
32. Pharmacology of rapid-onset antidepressant treatment strategies
33. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system
34. Synthesis and evaluation of 4-(2′-methoxyphenyl)-1-[2′-[N-(2″-pyridinyl)-p- iodobenzamido] ethyl]piperazine (p-MPPI): A new iodinated 5-HT1A ligand
35. 4-(2′-Methoxyphenyl)-1-[2′-[N-(2″-pyridinyl)-p- iodobenzamido]ethyl] piperazine and 4-(2′-methoxyphenyl)-1-[2′-[N-(2″-pyridinyl)-p- fluorobenzamido] ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors
36. 3H]p-MPPF
37. 18F]p-MPPF: A radiolabelled antagonist for the study of 5-HT1A receptors with PET
38. Changes in steady-state levels of tryptophan hydroxylase protein in adult rat brain after neonatal 6-hydroxydopamine lesion
39. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. An in vivo brain microdialysis study
40. The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
41. 18F] MPPF
42. 18F]p-MPPF
43. Neurobiology of an anorectic drug: Fenfluramine
44. Fenfluramine releases serotonin from human brain nerve endings by a dual mechanism
45. 11C] WAY 100635 to 5-HT1A receptors in rat brain, assessed using in vivo microdialysis and PET after fenfluramine
46. Nitric oxide modulates N-methyl-D-aspartate-evoked serotonin release in the raphe nuclei and frontal cortex of the freely moving rat
47. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat
48. Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review
49. Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights
50. Pindolol occupancy of 5-HT1A receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635