Safety of a GM-CSF adjuvant-plasmid DNA malaria vaccine

Gene Therapy

Volumn 8, Issue 13, 2001, Pages 1011-1023

  Parker, S E ^a   Monteith, D ^b,c   Horton, H ^a   Hof, R ^a   Hernandez, P ^a   Vilalta, A ^a   Hartikka, J ^a   Hobart, P ^a   Bentley, C E ^c   Chang, A ^c   Hedstrom, R ^d   Rogers, W O ^d   Kumar, S ^d   Hoffman, S L ^d   Norman, J A ^a  

^a VICAL INC   (United States)

^b Sierra Biomedical   (United States)

^c BioReliance   (United States)

^d NAVAL MEDICAL RESEARCH CENTER   (United States)

Author keywords

GM CSF; Malaria; Plasmid DNA vaccine; Safety

Indexed keywords

ADJUVANT; DNA VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MALARIA VACCINE; PLASMID DNA; PROTOZOAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG SAFETY; DRUG TOLERABILITY; EVALUATION; FEMALE; IMMUNOPATHOLOGY; INJECTION SITE; MALARIA; MALE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RABBIT; SERUM; TISSUE DISTRIBUTION; VASCULARIZATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, ANTINUCLEAR; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INJECTIONS, INTRADERMAL; INJECTIONS, INTRAMUSCULAR; MALARIA VACCINES; MALE; MICE; MICE, INBRED STRAINS; MUSCLE, SKELETAL; PLASMIDS; POLYMERASE CHAIN REACTION; RABBITS; TISSUE DISTRIBUTION; VACCINES, DNA;

EID: 0034939849     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301491     Document Type: Article

References (49)

1. Pathways and strategies for developing a malaria blood-stage vaccine
2. Preerythrocyte malaria vaccine development
3. Attacking the infected hepatocyte
4. Heterologous protection against influenza by injection of DNA encoding a viral protein
5. Bovine herpesvirus 1: Immune responses in mice and cattle injected with plasmid DNA
6. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus
7. Protection against Papillomavirus with a polynucleotide vaccine
8. DNA immunization against experimental genital herpes simplex virus infection
9. Protection of chimpanzees from high-dose heterologous challenge by DNA vaccination
10. Immunization for Ebola virus infection
11. Vaccination against tuberculosis by DNA injection
12. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
13. An ospa-based DNA vaccine protects mice against infection with borrelia brugdorferi
14. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major
15. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein
16. Safety, tolerability, and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers
17. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
18. Granulocyte-macrophage colony-stimulating factor and the immune system
19. Cytotoxic T cell responses to DNA vaccination: Dependence on antigen presentation via class II MHC
20. + T cells after gene gun immunization
21. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen presenting cells
22. Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope
23. DNA-based immunization by in vivo transfection of dendritic cells
24. Enhanced protection against viral infection by co-administration of plasmid DNA coding for viral antigens and cytokines in mice
25. Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte-macrophage colony-stimulating factor gene in intramuscular DNA immunization
26. DNA innoculations with HIV-1 recombinant genomes that express cytokine genes enhance HIV-1 specific immune responses
27. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV
28. Enhancement of protective humoral (Th2) and cell-mediated (TH1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes
29. Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA innoculation with the granulocyte-macrophage colony-stimulating factor gene
30. Protective immunity against heterologous challenge with encephalomyocarditis virus VP1 DNA vaccination: Effect of coinjection with a granulocyte-macrophage colony-stimulating factor gene
31. Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations with cytokine-expressing plasmids
32. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
33. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
34. DNA immunization induces protective immunity against B-cell lymphoma
35. A plasmid encoding granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine
36. Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
37. Induction of various autoantibodies by mutant gene lpr in several strains of mice
38. The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF
39. Receptor clearance obscures the magnitude of granulocyte-macrophage colony-stimulating factor responses in mice to endotoxin or local infections
40. Intramuscular administration of expression plasmids encoding interferon-g receptor/IgG1 or IL-4/IgG1 chimeric proteins protects from autoimmunity
41. In vitro and in vivo immunogenicity of Plasmodium falciparum pre-erythrocyte stage DNA vaccines
42. Plasmid DNA malaria vaccine: Tissue distribution and safety studies in mice and rabbits
43. Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids
44. Antitumor efficacy of plasmid DNA encoding the human IL-2 gene
45. An improved plasmid DNA expression vector for direct injection into skeletal muscle
46. Cancer gene therapy: Purification of DNA for human clinical trials
47. Quantification of plasmid DNA expression in vivo
48. Determination of Target Number of PCR Quantitative Standards