C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge

Nature Immunology

Volumn 1, Issue 2, 2000, Pages 127-131

  Ross, Ted M ^a,b   Xu, Yan ^a   Bright, Rick A ^a   Robinson, Harriet L ^a  

^a EMORY UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3D; DNA VACCINE; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS ANTIBODY;

ANIMAL; ANTIBODY AFFINITY; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL LINE; DISEASE MODEL; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; INFLUENZA; INFLUENZA VIRUS A; MOUSE; PLASMID;

ANIMALS; ANTIBODIES, VIRAL; ANTIBODY AFFINITY; CELL LINE, TRANSFORMED; COMPLEMENT C3D; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; PLASMIDS; VACCINES, DNA;

EID: 0034252626     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/77802     Document Type: Article

References (26)

1. Subbarao, K. Influenza vaccines: present and future. Adv. Virus Res. 54, 349-373 (1999).
2. Andrew, M.E., Coupar, B.E.H., Boyle, D.B. & Ada, G.L. The roles of influenza virus haemagglutinin and nucleoprotein in protection: analysis using vaccinia virus recombinants. Scand J. Immunol. 25, 21-25 (1987).
3. Robinson H.L. et al. DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs. J. Infect Dis. 176, S50-55 (1997).
4. Portela, A., Zucker, T., Nieto, A. & Ortin, J. Replication of Orthomyxoviruses. Adv. Virus. Res. 54, 319-348 (1999).
5. Murphy, B.R. & Webster, R.G. in Virology 2nd edition (eds Fields, B.N. et al.) 1091-1152 (Raven Press, New York, 1990).
6. Seder, R.A. & Gurunathan, S. DNA vaccines-designer vaccines for the 21st century. N. Engl. J. Med. 341, 277-178 (1999).
7. Donnelly J.J., Ulmer, J.B. & Liu, M.A. DNA vaccines. Dev. Biol. Stand. 95, 43-53 (1998).
8. Robinson H.L. & Pertmer, T.M. DNA vaccines for viral infections: Basic studies and applications. Adv. Virus Res. (2000) (in the press).
9. Robinson, H.L., Hunt, L.A. & Webster, R.G. Protection against a lethal influenza virus challenge by immunization with a hemagglutinin-expressing plasmid DNA. Vaccine 11, 957-960 (1993).
10. Zuckerman, M.A. et al. Serological response in volunteers to inactivated trivalent subunit influenza vaccine: antibody reactivity with epidemic influenza A and B strains and evidence of a rapid immune response. J. Med. Virol. 33, 133-137 (1991).
11. Rimmelwaan, G.F. et al. Induction of protective immunity against influenza virus in a macaque model: comparison of conventional and iscom vaccines. J. Gen. Virol. 78, 757-765 (1997).
12. Dempsey, P.W., Allison, M.E.D., Akkaraju, S., Goodnow, C.C. & Fearon, D.T. C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity. Science 271, 348-350 (1996).
13. Fearon, D.T. & Carter, R.H. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu. Rev. Immunol. 13, 127-149 (1995).
14. Gething, M.J. & Sambrook, J. Construction of influenza hemagglutinin gene that code for intracellular and secreted forms of the protein. Nature 300, 598-603 (1982).
15. Pullen, G.R., Fitzgerald, M.G. and Hosking, C.S. Antibody avidity determination by ELISA using thiocyanate elution. J. Immunol. Meth. 86, 83-67 (1986).
16. Fearon, D.T. The complement system and adaptive immunity. Semin Immunol. 10, 355-361 (1998).
17. Berek, C., Berger, A. & Apel, M. Maturation of the immune response in germinal centers. Cell 67, 1121-1129 (1991).
18. Jacob, J., Kelsoe, G., Rajewsky, K. & Weiss, U. Intraclonal generation of antibody mutants in germinal centres. Nature 354, 389-392 (1991).
19. Ahearn, J.M., et al. Disruption of the CR2 locus results in a reduction in B-1a cells and in a impaired B cell response to T-dependent antigen. Immunity 4, 251-262 (1996).
20. Potter, C.W., Jennings, R., Phair, J.P., Clarke, A. & Stuart-Harris, C.H. Dose response relationship after immunization of volunteers with a new surface-antigen-adsorbed influenza virus vaccine. J. Infect Dis. 155, 423-431 (1977).
21. Scholtissek, S. & Grosse, F. A cloning cartridge of λ ζ terminator. Nuc. Acids Res. 15, 3185 (1987).
22. Torres, C.A.T., Yang, K., Mustafa, F. & Robinson, H.L. DNA immunization: effect of secretion of DNA expressed hemagglutinins on antibody responses in preparation. Vaccine 18, 805-814 (1999).
23. Pertmer T.M. & Robinson, H.L Studies on antibody responses following neonatal immunization with influenza hemagglutinin DNA or protein. Virology 257, 406-414 (1999).
24. Haynes, J.R., Fuller, D.H., Eisenbraun, M.D., Ford M.J. & Pertmer, T.M. Accell particle-mediated DNA immunization elicits humoral, cytotoxic, and protective immune responses. AIDS Res. Hum. Retroviuses. 10, S43-45 (1994).
25. Pertmer, T.M. et al. Gene gun based nucleic acid immunization, eliciting of humoral and cytotoxic T lymphocyte response following epidermal delivery of nanogram quantitation of DNA. Vaccine 13, 1427-1430 (1995).
26. Montgomery, D. L. et al. Heterologous and homologous protection against influenza A by DNA vaccination: Optimization of DNA vectors. DNA Cell Biol. 12, 777-783 (1993).