Unique functions of sonic hedgehog signaling during external genitalia development

Development

Volumn 128, Issue 21, 2001, Pages 4241-4250

  Haraguchi, R ^a   Mo, R ^a   Hui, C C ^a   Motoyama, J ^a   Makino, S ^a   Shiroishi, T ^a   Gaffield, W ^a   Yamada, G ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Bmp; External genitalia; Fgf; Genital tubercle; Hypospadias; Mouse; Shh; Urethra

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 10; GENE PRODUCT; HOMEOBOXD13 PROTEIN; HOMEODOMAIN PROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; COPULATION; EMBRYO; EMBRYOLOGY; EPITHELIUM; FERTILIZATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ANALYSIS; GENETIC REGULATION; GENITAL SYSTEM; GONAD DEVELOPMENT; GONADAL AGENESIS; MESENCHYME; MOLECULAR BIOLOGY; MORPHOGENESIS; MOUSE; NONHUMAN; OBSERVATION; ORGAN CULTURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE GROWTH; URETHRA;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; EMBRYONIC INDUCTION; FEMALE; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENITALIA; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MESODERM; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MUTATION; ORGAN CULTURE TECHNIQUES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; ERINACEIDAE; MURINAE;

EID: 0035160112     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. External genitalia of the rat: Normal development and the histogenesis of 5 alpha-reductase inhibitor-induced abnormalities
2. Ectopic application of recombinant BMP-2 and BMP-4 can change patterning of developing chick facial primordia
3. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
4. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
5. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
6. Shaping limbs by apoptosis
7. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
8. Manifestation of the limb prepattern: Limb development in the absence of sonic hedgehog function
9. Developmental basis of limblessness and axial patterning in snakes
10. Teratogen-mediated inhibition of target tissue response to Shh signaling
11. BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo
12. Age-dependent loss of sensitivity of female urogenital sinus to androgenic conditions as a function of the epithelia-stromal interaction in mice
13. Sonic hedgehog regulates growth and morphogenesis of the tooth
14. Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
15. The vertebrate limb: A model system to study the Hox/HOM gene network during development and evolution
16. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
17. HOX-4 genes and the morphogenesis of mammalian genitalia
18. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
19. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
20. Steroidal alkaloid teratogenesis: Molecular probes for investigation of craniofacial malformations
21. A looking glass perspective: Thalidomide and cyclopamine
22. Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod
23. The origin and fate of the urethral plate in man
24. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
25. Evidence for the involvement of the Gli gene family in embryonic mouse lung development
26. Molecular analysis of external genitalia formation: The role of fibroblast growth factor (Fgf) genes during genital tubercle formation
27. The Shh signalling pathway in tooth development: Defects in Gli2 and Gli3 mutants
28. Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model
29. Gene duplication: Past, present and future
30. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
31. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
32. Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse
33. Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway
34. Of fingers, toes and penises
35. Insights from the study of animals lacking functional estrogen receptor
36. Some distal limb structures develop in mice lacking Sonic hedgehog signaling
37. Ontogeny of the male urethra: Theory of endodermal differentiation
38. Epithelial-mesenchymal interactions in development of the mouse fetal genital tubercle
39. Urethral development in the fetal rabbit and induction of hypospadias: A model for human development
40. Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate
41. Fibroblast growth factor interactions in the developing lung
42. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
43. Sonic hedgehog is essential to foregut development
44. Biochemical evidence that patched is the Hedgehog receptor
45. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
46. Mouse patched1 controls body size determination and limb patterning
47. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
48. Mutation of HOXA13 in hand-foot-genital syndrome
49. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
50. A histological study of the development of the penis of wild-type and androgen-insensitive mice
51. Histogenesis of the Os penis and Os clitoridis in rats
52. Proximal-distal sequence of development of the skeletal tissues in the penis of rat and the inductive effect of epithelium
53. BMPs are necessary for stomach gland formation in the chicken embryo: A study using virally induced BMP-2 and Noggin expression
54. Expression of the homeotic gene Hox-d13 in the developing and adult mouse prostate
55. External genitalia formation: Role of fibroblast growth factor, retinoic acid signaling and distal urethral epithelium (DUE)
56. Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity
57. Basal cell carcinomas in mice overexpressing sonic hedgehog
58. Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut
59. Mouse Gli 1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
60. Sonic hedgehog regulates branching morphogenesis in the mammalian lung
61. BMPs negatively regulate structure and function of the limb apical ectodermal ridge
62. Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium
63. Hedgehog signals regulate multiple aspects of gastrointestinal development
64. Sonic hedgehog mediates the polarizing activity of the ZPA
65. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut
66. Epithelial-mesenchymal signaling during the regionalization of the chick gut
67. Paracrine-mediated apoptosis in reproductive tract development
68. Sex determination genes control the development of the Drosophila genital disc, modulating the response to Hedgehog, Wingless and Decapentaplegic signals
69. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
70. The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
71. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
72. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
73. Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages
74. The enamel knot as a signaling center in the developing mouse tooth
75. Apoptosis in the developing tooth: Association with an embryonic signaling center and suppression by EGF and FGF-4
76. The normal development of the anorectum in the pig
77. The Assessment of Hypospadias
78. Normal development of the male anterior urethra
79. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
80. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
81. Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds