Two dominant mutations in the mouse Fused gene are the result of transposon insertions

Genetics

Volumn 147, Issue 2, 1997, Pages 777-786

  Vasicek, Thomas J ^a,c   Zeng, Li ^b   Guan, X J ^a   Zhang, Tong ^b   Costantini, Frank ^b   Tilghman, Shirley M ^a  

^a PRINCETON UNIVERSITY   (United States)

^b Columbia Coll of Phys and Surgeons ^*  (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; EMBRYO AXIS; GENE INSERTION; GENE LOCUS; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSPOSON;

ANIMALS; BASE SEQUENCE; DNA; GENES, DOMINANT; HOMOZYGOTE; MICE; MUTATION; PROTEINS; REPRESSOR PROTEINS; RETROELEMENTS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA; DROSOPHILA MELANOGASTER; INTRACISTERNAL A-PARTICLES; MELANOGASTER;

EID: 0030776825     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. ALLEN, N. D., M. L. NORRIS and M. A. SURANI, 1990 Epigenetic control of transgene expression and imprinting by genotype-specific modifiers. Cell 61: 853-861.
2. AUFFRAY, C., and K. ROUGEON, 1980 Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur. J. Biochem. 107: 303-314.
3. BEECHEY, C. V., and B. M. CATTANACH, 1996 Genetic imprinting map. Mouse Gen. 94: 96-99.
4. CASPARI, E., and P. R. DAVID, 1940 The inheritance of a tail abnormality in the house mouse. J. Hered. 31: 427-431.
5. CHAN, R. K., and C. A. OTTE, 1982 Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol. Cell Biol. 2: 21-29.
6. CHOMCZYNSKI, P., and N. SACCHI, 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
7. CHRISTY, R. J., and R. C. HUANG, 1988 Functional analysis of the long terminal repeats of intracisternal A-particle genes: sequences within the U3 region determine both efficiency and direction of promoter activity. Mol. Cell Biol. 8: 1093-1102.
8. DEOL, M. S., 1966 The probable mode of gene action in the circling mutants. Genet. Res. 7: 363-371.
9. DIETZEL, C., and J. KURJAN, 1987 Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: a model for desensitization to pheromone. Mol. Cell. Biol. 7: 4169-4177.
10. DOHLMAN, H. G., and J. THORNER, 1997 RGS proteins: filling in the GAPs in heterotrimeric G protein signalling. J. Biol. Chem. 272: 3871-3874.
11. DOHLMAN, H. G., D. APANIESK, Y. CHEN, J. SONG and D. NUSSKERN, 1995 Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 3635-3643.
12. DUHL, D. M., H. VRIELING, K. A. MILLER, G. L. WOLFF and G. S. BARSH, 1994 Neomorphic agouti mutations in obese yellow mice. Nature Gen. 8: 59-65.
13. DUNN, L. C., and E. CASPARI, 1945 A case of neighboring loci with similar effects. Genetics 30: 543-568.
14. DUNN, L. C., and S. GLUECKSOHN-WAELSCH, 1954 A genetical study of the mutation "Fused" in the house mouse, with evidence concerning its allelism with a similar mutation "Kink." J. Genetics 52: 383-391.
15. FEINBERG, A. P., and B. VOGELSTEIN, 1984 A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137: 266-267.
16. GLUECKSOHN-SCHOENHEIMER, S., 1949 The effects of a lethal mutation responsible for duplications and twinning in mouse embryos. J. Exp. Zool. 110: 47-76.
17. GRECO, T. L., S. TAKADA, M. M. NEWHOUSE, J. A. MCMAHON and A. P. MCMAHON, 1996 Analysis of the vestigial tail mutation demonstrates that Wnt-3A gene dosage regulates mouse axial development. Genes Dev. 10: 313-324.
18. GREENSPAN, R. J., and M. C. O'BRIEN, 1986 Genetic analysis of mutations at the fused locus in the mouse. Proc. Natl. Acad. Sci. USA 83: 4413-4417.
19. HADCHOUEL, M., H. FARZA, D. SIMON, P. TIOLLIAS and C. POURCEL, 1987 Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature 329: 454-456.
20. HERRMANN, B. G., S. LABEIT, A. POUSTKA, T. R. KING and H. LEHRACH, 1990 Cloning of the T gene required in mesoderm formation in the mouse. Nature 343: 617-622.
21. JACOBS-COHEN, R. J., M. SPIEGELMAN, J. C. COOKINGHAM and D. BENNETT, 1984 Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization. Genet. Res. 43: 43-50.
22. KLINGENSMITH, J., R. NUSSE and N. PERRIMON, 1994 The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 8: 118-130.
23. KOELLE, M. R., and H. R. HORVITZ, 1996 Egl-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84: 115-125.
24. KOZAK, M., 1986 Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44: 283-92.
25. KOZAK, M., 1989 Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol. Cell. Biol. 9: 5134-5142.
26. KUFF, E. L., and K. K. LUEDERS, 1988 The intracisternal A-particle gene family: structure and functional aspects. Adv. Cancer Res. 51: 183-276.
27. LAMB, B. T., L. L. SATYAMOORTHY, D. SOLTER and C. C. HOWE, 1991 CpG methylation of an endogenous retroviral enhancer inhibits trnscription factor binding and activity. Gene Express. 1: 185-196.
28. MACMURRAY, A., and H.-S. SHIN, 1988 The antimorphic nature of the Tc allele at the mouse T locus. Genetics 120: 545-550.
29. MICHAUD, E. J., M. J. VAN VUGT, S. J. BULTMAN, H. O. SWEET and M. T. DAVISSON, 1994 Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev. 8: 1463-1472.
30. MIETZ, J. A., Z. GROSSMAN, K. K. LUEDERS and E. L. KUFF, 1987 Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function. J. Virol. 61: 3020-3029.
31. NOORDERMEER, J., J. KLINGENSMITH, N. PERRIMON and R. NUSSE, 1994 Dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature 367: 80-83.
32. PERRY, W. L. I., T. J. VASICEK, J. J. LEE, J. M. ROSSI and L. ZENG, 1995 Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. Genetics 141: 321-332.
33. POZNANSKI, A. A., and P. G. CALARCO, 1991 The expression of intracisternal A particle genes in the preimplantation mouse embryo. Dev. Biol. 143: 271-281.
34. REED, C. S., 1937 The inheritance and expression of fused, a new mutation in the house mouse. Genetics 22: 1-13.
35. REIK, W., A. COLLICK, M. L. NORRIS, S. C. BARTON and M. A. SURANI, 1987 Genomic imprinting determines methylation of parental alleles in transgenic mice. Nature 328: 248-251.
36. ROSSI, J. M., H. CHEN and S. M. TILGHMAN, 1994 Genetic map of the Fused locus on mouse chromosome 17. Genomics 23: 178-184.
37. RUVINSKY, A. O., and A. I. AGULNIK, 1990 Genetic imprinting and the manifestation of the Fused gene in the house mouse. Dev. Genet. 11: 263-269.
38. RUVINSKY, A., A. AGULNIK, S. AGULNIK and M. ROGACHOVA, 1991 Functional analysis of mutations of murine chromosome 17 with the use of tertiary trisomy. Genetics 127: 781-788.
39. SANFORD, J. P., H. J. CLARK, V.M. CHAPMAN and J. ROSSANT, 1987 Differences in DNA methylation during oogenesis and spermatogenesis and their persistance during early embryogenesis in the mouse. Genes Dev. 1: 1039-1046.
40. SAPIENZA, C., A. C. PETERSON, J. ROSSANT and R. BALLING, 1987 Degree of methylation of transgenes is dependent on gamete of origin. Nature 328: 251-254.
41. SASAKI, H., T. HAMADA, T. UEDA, R. SEKI, T. HIGASHINAKAGAWA et al., 1991 Inherited type of allelic methylation variations in a mouse chromosome region where an integrated transgene shows methylation imprinting. Development 111: 573-581.
42. STOTT, D., A. KISPERT and B. G. HERRMANN, 1993 Rescue of the tail defect of Brachyury mice. Genes Dev. 7: 197-203.
43. SUTHERLAND, H. F., E. PICK, E. FRANCIS, H. LEHRACH and A.-M. FRISCHAUF, 1995 Mapping around the Fused locus on mouse Chromosome 17. Mammal. Gen. 6: 449-453.
44. TAM, P. P. L., and S.-S. TAN, 1992 The somitogenic potential of cells in the primitive streak and tail bud of organogenesis stage mouse embryo. Development 115: 703-715.
45. THEILER, K., and S. GLUECKSOHN-WAELSCH, 1956 The morphological effects and the development of the Fused mutation in the mouse. Anal. Rec. 125: 83-104.
46. THEISEN, H., J. PURCELL, M. BENNETT, D. KANSAGARA, A. SYED et al., 1994 dishevelled is required during wingless siganling to establish both cell polarity and cell identity. Development 120: 347-360.
47. TSANG, S. S., X. YIN, C. GUZZO-ARDURAN, V. S. JONES and A. J. DAVISON, 1992 One-hour downward alkaline capillary transfer for blotting of DNA and RNA. Anal. Biochem. 201: 134-139.
48. UEDA, T., K. YAMAZAKI, R. SUZUKI, H. FUJIMOTO, H. SASAKI et al., 1992 Parental methylation patterns of a transgenic locus in adult somatic tissues are imprinted during gametogenesis. Development 116: 831-839.
49. VOGT, T. F., L. JACKSON-GRUSBY, A. J. WYNSHAW-BORIS, D. C. CHAN and P. LEDER, 1992 The same genomic region is disrupted in two transgene-induced limb deformity alleles. Mammal. Gen. 3: 431-437.
50. WOLFF, G. L., 1971 Genetic modification of homeostatic regulation in the mouse. Am. Nat 105: 241-252.
51. WOLFF, G. L., 1978 Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics 88: 529-539.
52. ZENG, L., F. FAGOTTO, T. ZHANG, W. Hsu, T. J. VASICEK et al., 1997 The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation in mammals and amphibians. Cell 90: 181-192.