Asynchronous coreceptor downregulation after positive thymic selection: Prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor

Journal of Experimental Medicine

Volumn 185, Issue 2, 1997, Pages 357-362

  Barthlott, Thomas ^a   Kohler, Hubertus ^a   Eichmann, Klaus ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL SELECTION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GROWTH REGULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANTIGENS, CD4; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; DOWN-REGULATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PROTEIN BIOSYNTHESIS; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 0031054634     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.2.357     Document Type: Article

References (21)

1. von-Boehmer, H. 1992. Thymic selection: a matter of life and death. Immunol. Today. 13:454-458.
2. Robey, E., and B.J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675-705.
3. Brandle, D., S. Muller, C. Muller, H. Hengartner, and H. Pircher. 1994. Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection. Eur. J. Immunol. 24:145-151.
4. Bendelac, A., P. Matzinger, R.A. Seder, W.E. Paul, and R.H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731-742.
5. Swat, W., M. Dessing, H. von Boehmer, and P. Kisielow. 1993. CD69 expression during selection and maturation of CD4+8+ thymocytes. Eur. J. Immunol. 23:739-746.
6. Ceredig, R., D.P. Dialynas, F.W. Fitch, and H.R. MacDonald. 1983. Precursors of T cell growth factor producing cells in the thymus. J. Exp. Med. 158:1654-1671.
7. Lucas, B., F. Vasseur, and C. Penit. 1994. Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153:53-62.
8. Marodon, G., and B. Rocha. 1994. Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation. Eur. J. Immunol. 24:196-204.
9. Anderson, G., J.J. Owen, N.C. Moore, and E.J. Jenkinson. 1994. Characteristics of an in vitro system of thymocyte positive-selection. J. Immunol. 153:1915-1920.
10. Lundberg, K., and K. Shortman. 1994. Small cortical thymocytes are subject to positive selection. J. Exp. Med. 179: 1475-1483.
11. + double-positive stage indicates positive selection. Int. Immunol. 8:101-113.
12. Wilkinson, R.W., G. Anderson, J.J.T. Owen, and E.J. Jenkinson. 1995. Positive selection of thymocytes involves sustained interactions with the thymic microenvironment. J. Immunol. 155:5234-5240.
13. - single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vβ family. Proc. Natl. Acad. Sci. USA. 89:6506-6510.
14. + cells: new clues to their origin, specificity and function. J. Exp. Med. 182:633-638.
15. Petrie, H.T., A. Strasser, A.W. Harris, P. Hugo, and K. Shortman. 1993. CD4+8-and CD4-8+ mature thymocytes require different post-selection processing for final development. J. Immunol. 151:1273-1279.
16. + T cell lineages: a new perspective on thymic commitment and selection. Immunity. 2: 413-425.
17. ht thymocytes. J. Exp. Med. 181:1643-1651.
18. Ravichandran, K.S., and S.J. Burakoff. 1994. Evidence for differential signaling via CD4 and CD8 molecules. J. Exp. Med. 179:727-732.
19. Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella, and E. Robey. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage cells. J. Exp. Med. 183:731-741.
20. Veillette, A., J.C. Zuniga Pflucker, J.B. Bolen, and A.M. Kruisbeek. 1989. Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J. Exp. Med. 170:1671-1680.
21. Matechak, E.O., N. Killeen, S.M. Hedrick, and B.J. Fowlkes. 1996. MHC class II-specific T cells can develop into the CD8 lineage when CD4 is absent. Immunity. 4:337-347.