Signalling via MHC class II molecules modifies the composition of GEMs in APC

Scandinavian Journal of Immunology

Volumn 54, Issue 1-2, 2001, Pages 87-92

  Setterblad, N ^a   Becart, S ^a   Charron, D ^a   Mooney, N ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHOLESTEROL; GANGLIOSIDE GM1; GLYCOLIPID ENRICHED MEMBRANE MICRODOMAIN; HLA DR ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACTINS; ANTIGEN-PRESENTING CELLS; CELLS, CULTURED; CHOLESTEROL; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HUMANS; ISOENZYMES; MEMBRANE MICRODOMAINS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; SIGNAL TRANSDUCTION;

EID: 0034958644     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2001.00969.x     Document Type: Article

References (16)

1. Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity
2. Lymphocyte programmed cell death is mediated via HLA-class II DR
3. Two distinct signal transduction pathways lead to either programmed cell death or cellular activation following HLA class II stimulation
4. Ia binding ligands and cAMP induced nuclear translocation of protein kinase C
5. Protein kinase C activation via human leucocyte antigen class II molecules, a novel regulation of PKC activity
6. HLA-DR mediated translocation of PKCα and PKC βII isoforms is abrogated by deletion of the DRβ cytoplasmic tail
7. The cytoplasmic and transmembrane domains of MHC class II β chains deliver distinct signals required for MHC class II-mediated B cell activation
8. Functions of lipid rafts in biological membranes
9. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
10. Intracellular phosphotyrosine induction by major histocompatibility complex class requires co-aggregation with membrane rafts
11. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation
12. Membrane compartmentation is required for efficient T cell activation
13. B cell antigen receptor signaling occurs outside lipid rafts in immature B cells
14. T lymphocyte co-stimulation mediated by re-organization of membrane microdomains
15. Signaling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression