메뉴 건너뛰기




Volumn 207, Issue 1, 2005, Pages 137-147

Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride

Author keywords

Fumonisin; Hepatotoxicity; Kupffer cells; Sphinganine; Tumor necrosis factor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FUMONISIN B1; GADOLINIUM CHLORIDE; GAMMA INTERFERON; LYMPHOTOXIN BETA; SODIUM CHLORIDE; SPHINGANINE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; CYTOKINE; CYTOKINE RECEPTOR; FUMONISIN; GADOLINIUM;

EID: 10044237489     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.09.013     Document Type: Article
Times cited : (23)

References (62)
  • 1
    • 0028179067 scopus 로고
    • Activation of multiple NFκB/Rel DNA-binding complexes by tumor necrosis factor
    • A.A. Beg, and A.S. Baldwin Jr. Activation of multiple NFκB/Rel DNA-binding complexes by tumor necrosis factor Oncogene 9 1994 1487 1492
    • (1994) Oncogene , vol.9 , pp. 1487-1492
    • Beg, A.A.1    Baldwin Jr., A.S.2
  • 2
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NFκB in preventing TNFα-induced cell death
    • A.A. Beg, and D. Baltimore An essential role for NFκB in preventing TNFα-induced cell death Science 274 1996 782 784
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 3
    • 0022749157 scopus 로고
    • International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: Approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase (l-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1)
    • H.U. Bergmeyer, M. Hørder, and R. Rej International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase (l-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1) J. Clin. Chem. Clin. Biochem. 24 1986 497 510
    • (1986) J. Clin. Chem. Clin. Biochem. , vol.24 , pp. 497-510
    • Bergmeyer, H.U.1    Hørder, M.2    Rej, R.3
  • 4
    • 0022742360 scopus 로고
    • International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: Approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase (l-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2)
    • H.U. Bergmeyer, M. Hørder, and R. Rej International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase (l-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2) J. Clin. Chem. Clin. Biochem. 24 1986 481 495
    • (1986) J. Clin. Chem. Clin. Biochem. , vol.24 , pp. 481-495
    • Bergmeyer, H.U.1    Hørder, M.2    Rej, R.3
  • 8
    • 0028178798 scopus 로고
    • Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
    • B. Cheng, S. Christakos, and M.P. Mattson Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis Neuron 12 1994 139 153
    • (1994) Neuron , vol.12 , pp. 139-153
    • Cheng, B.1    Christakos, S.2    Mattson, M.P.3
  • 9
    • 0028282153 scopus 로고
    • 1 and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of esophageal cancer
    • 1 and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of esophageal cancer Appl. Environ. Microbiol. 60 1994 847 852
    • (1994) Appl. Environ. Microbiol. , vol.60 , pp. 847-852
    • Chu, F.S.1    Li, G.Y.2
  • 12
    • 0032526358 scopus 로고    scopus 로고
    • IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections
    • S.H. Gregory, E.J. Wing, K.L. Danowski, N. van Rooijen, K.F. Dyer, and D.J. Tweardy IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections J. Immunol. 160 1998 6056 6061
    • (1998) J. Immunol. , vol.160 , pp. 6056-6061
    • Gregory, S.H.1    Wing, E.J.2    Danowski, K.L.3    Van Rooijen, N.4    Dyer, K.F.5    Tweardy, D.J.6
  • 13
    • 0026728411 scopus 로고
    • Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation
    • M.J. Hardonk, F.W. Dijkhuis, C.E. Hulstaert, and J. Koudstaal Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation J. Leukoc. Biol. 52 1992 296 302
    • (1992) J. Leukoc. Biol. , vol.52 , pp. 296-302
    • Hardonk, M.J.1    Dijkhuis, F.W.2    Hulstaert, C.E.3    Koudstaal, J.4
  • 14
    • 0036566502 scopus 로고    scopus 로고
    • Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice
    • E.B. Harstad, and C.D. Klaassen Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice Toxicol. Appl. Pharmacol. 180 2002 178 185
    • (2002) Toxicol. Appl. Pharmacol. , vol.180 , pp. 178-185
    • Harstad, E.B.1    Klaassen, C.D.2
  • 15
    • 0035000827 scopus 로고    scopus 로고
    • Fumonisin toxicosis in swine: An overview of porcine pulmonary edema and current perspectives
    • W.M. Haschek, L.A. Gumprecht, G. Smith, M.E. Tumbleson, and P.D. Constable Fumonisin toxicosis in swine: an overview of porcine pulmonary edema and current perspectives Environ. Health Perspect. 109 Suppl. 2 2001 251 257
    • (2001) Environ. Health Perspect. , vol.109 , Issue.2 , pp. 251-257
    • Haschek, W.M.1    Gumprecht, L.A.2    Smith, G.3    Tumbleson, M.E.4    Constable, P.D.5
  • 16
    • 0035395599 scopus 로고    scopus 로고
    • Fumonisin-induced tumor necrosis factor α expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition
    • Q. He, R.T. Riley, and R.P. Sharma Fumonisin-induced tumor necrosis factor α expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition Toxicol. Appl. Pharmacol. 174 2001 69 77
    • (2001) Toxicol. Appl. Pharmacol. , vol.174 , pp. 69-77
    • He, Q.1    Riley, R.T.2    Sharma, R.P.3
  • 17
    • 0036257964 scopus 로고    scopus 로고
    • 1): A model for reducing fumonisin-induced nephrotoxicity in vivo
    • 1): a model for reducing fumonisin-induced nephrotoxicity in vivo Pharmacol. Toxicol. 90 2002 268 277
    • (2002) Pharmacol. Toxicol. , vol.90 , pp. 268-277
    • He, Q.1    Riley, R.T.2    Sharma, R.P.3
  • 18
    • 4344629494 scopus 로고    scopus 로고
    • 1 despite increasing accumulation of free sphingoid bases
    • 1 despite increasing accumulation of free sphingoid bases Toxicol. Sci. 80 2004 335 342
    • (2004) Toxicol. Sci. , vol.80 , pp. 335-342
    • He, Q.1    Kim, J.2    Sharma, R.P.3
  • 21
    • 0034071926 scopus 로고    scopus 로고
    • Diethyldithiocarbamate enhances production of nitric oxide and TNFα by lipopolysaccharide-stimulated rat Kupffer cells
    • H. Ishiyama, N.C. Hoglen, and I.G. Sipes Diethyldithiocarbamate enhances production of nitric oxide and TNFα by lipopolysaccharide-stimulated rat Kupffer cells Toxicol. Sci. 55 2000 206 214
    • (2000) Toxicol. Sci. , vol.55 , pp. 206-214
    • Ishiyama, H.1    Hoglen, N.C.2    Sipes, I.G.3
  • 23
    • 0345196005 scopus 로고    scopus 로고
    • Gadolinium chloride inhibition of rat hepatic microsomal epoxide hydrolase and glutathioneine-S-transferase gene expression
    • S.G. Kim, and S.H. Choi Gadolinium chloride inhibition of rat hepatic microsomal epoxide hydrolase and glutathioneine-S-transferase gene expression Drug Metab. Dispos. 25 1997 1416 1423
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1416-1423
    • Kim, S.G.1    Choi, S.H.2
  • 25
    • 0028948724 scopus 로고
    • Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
    • D.L. Laskin, C.R. Gardner, V.F. Price, and D.J. Jollow Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen Hepatology 21 1995 1045 1050
    • (1995) Hepatology , vol.21 , pp. 1045-1050
    • Laskin, D.L.1    Gardner, C.R.2    Price, V.F.3    Jollow, D.J.4
  • 26
    • 0034892257 scopus 로고    scopus 로고
    • Functional heterogeneity in liver and lung macrophages
    • D.L. Laskin, B. Weinberger, and J.D. Laskin Functional heterogeneity in liver and lung macrophages J. Leukoc. Biol. 70 2001 163 170
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 163-170
    • Laskin, D.L.1    Weinberger, B.2    Laskin, J.D.3
  • 27
    • 0030756389 scopus 로고    scopus 로고
    • The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors
    • A. Lieber, C.Y. He, L. Meuse, D. Schowalter, I. Kirillova, B. Winther, and M.A. Kay The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors J. Virol. 71 1997 8798 8807
    • (1997) J. Virol. , vol.71 , pp. 8798-8807
    • Lieber, A.1    He, C.Y.2    Meuse, L.3    Schowalter, D.4    Kirillova, I.5    Winther, B.6    Kay, M.A.7
  • 28
    • 0030990177 scopus 로고    scopus 로고
    • Bile ducts and portal and central veins are major producers of tumor necrosis factor α in regenerating rat liver
    • S. Loffreda, R. Rai, S.Q. Yang, H.Z. Lin, and A.M. Diehl Bile ducts and portal and central veins are major producers of tumor necrosis factor α in regenerating rat liver Gastroenterology 112 1997 2089 2098
    • (1997) Gastroenterology , vol.112 , pp. 2089-2098
    • Loffreda, S.1    Rai, R.2    Yang, S.Q.3    Lin, H.Z.4    Diehl, A.M.5
  • 29
    • 0035001015 scopus 로고    scopus 로고
    • Discovery and occurrence of the fumonisins: A historical perspective
    • W.F. Marasas Discovery and occurrence of the fumonisins: a historical perspective Environ. Health Perspect. 109 Suppl. 2 2001 239 243
    • (2001) Environ. Health Perspect. , vol.109 , Issue.2 , pp. 239-243
    • Marasas, W.F.1
  • 33
    • 0027787984 scopus 로고
    • 1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
    • 1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ J. Biol. Chem. 268 1993 27299 27306
    • (1993) J. Biol. Chem. , vol.268 , pp. 27299-27306
    • Merrill Jr., A.H.1    Van Echten, G.2    Wang, E.3    Sandhoff, K.4
  • 34
    • 0037135536 scopus 로고    scopus 로고
    • De novo sphingolipid biosynthesis: A necessary, but dangerous, pathway
    • A.H. Merrill Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway J. Biol. Chem. 277 2002 25843 25846
    • (2002) J. Biol. Chem. , vol.277 , pp. 25843-25846
    • Merrill Jr., A.H.1
  • 35
    • 0033000310 scopus 로고    scopus 로고
    • Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
    • S.L. Michael, N.R. Pumford, P.R. Mayeux, M.R. Niesman, and J.A. Hinson Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species Hepatology 30 1999 186 195
    • (1999) Hepatology , vol.30 , pp. 186-195
    • Michael, S.L.1    Pumford, N.R.2    Mayeux, P.R.3    Niesman, M.R.4    Hinson, J.A.5
  • 36
  • 37
    • 0035399943 scopus 로고    scopus 로고
    • TNFα-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes
    • Y. Osawa, Y. Banno, M. Nagaki, D.A. Brenner, T. Naiki, Y. Nozawa, S. Nakashima, and H. Moriwaki TNFα-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes J. Immunol. 167 2001 173 180
    • (2001) J. Immunol. , vol.167 , pp. 173-180
    • Osawa, Y.1    Banno, Y.2    Nagaki, M.3    Brenner, D.A.4    Naiki, T.5    Nozawa, Y.6    Nakashima, S.7    Moriwaki, H.8
  • 39
  • 41
    • 0026815544 scopus 로고
    • A review and update of animal toxicoses associated with fumonisin-contaminated feeds and production of fumonisins by Fusarium isolates
    • P.F. Ross, L.G. Rice, G.D. Osweiler, P.E. Nelson, J.L. Richard, and T.M. Wilson A review and update of animal toxicoses associated with fumonisin-contaminated feeds and production of fumonisins by Fusarium isolates Mycopathologia 117 1992 109 114
    • (1992) Mycopathologia , vol.117 , pp. 109-114
    • Ross, P.F.1    Rice, L.G.2    Osweiler, G.D.3    Nelson, P.E.4    Richard, J.L.5    Wilson, T.M.6
  • 42
    • 0027347282 scopus 로고
    • Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins
    • P.F. Ross, A.E. Ledet, D.L. Owens, L.G. Rice, H.A. Nelson, G.D. Osweiler, and T.M. Wilson Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins J. Vet. Diagn. Invest. 5 1993 69 74
    • (1993) J. Vet. Diagn. Invest. , vol.5 , pp. 69-74
    • Ross, P.F.1    Ledet, A.E.2    Owens, D.L.3    Rice, L.G.4    Nelson, H.A.5    Osweiler, G.D.6    Wilson, T.M.7
  • 44
    • 0033980632 scopus 로고    scopus 로고
    • Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor
    • R.P. Sharma, N. Bhandari, R.T. Riley, K.A. Voss, and F.I. Meredith Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor Toxicology 143 2000 183 194
    • (2000) Toxicology , vol.143 , pp. 183-194
    • Sharma, R.P.1    Bhandari, N.2    Riley, R.T.3    Voss, K.A.4    Meredith, F.I.5
  • 45
    • 0033759550 scopus 로고    scopus 로고
    • Fumonisin hepatotoxicity is reduced in mice carrying the human tumour necrosis factor α transgene
    • R.P. Sharma, N. Bhandari, M. Tsunoda, R.T. Riley, and K.A. Voss Fumonisin hepatotoxicity is reduced in mice carrying the human tumour necrosis factor α transgene Arch. Toxicol. 74 2000 238 248
    • (2000) Arch. Toxicol. , vol.74 , pp. 238-248
    • Sharma, R.P.1    Bhandari, N.2    Tsunoda, M.3    Riley, R.T.4    Voss, K.A.5
  • 46
    • 0035925081 scopus 로고    scopus 로고
    • Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1
    • R.P. Sharma, N. Bhandari, Q. He, R.T. Riley, and K.A. Voss Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1 Toxicology 159 2001 69 79
    • (2001) Toxicology , vol.159 , pp. 69-79
    • Sharma, R.P.1    Bhandari, N.2    He, Q.3    Riley, R.T.4    Voss, K.A.5
  • 47
    • 0037010619 scopus 로고    scopus 로고
    • Paradoxical role of tumor necrosis factor α in fumonisin-induced hepatotoxicity in mice
    • R.P. Sharma, Q. He, F.I. Meredith, R.T. Riley, and K.A. Voss Paradoxical role of tumor necrosis factor α in fumonisin-induced hepatotoxicity in mice Toxicology 180 2002 221 232
    • (2002) Toxicology , vol.180 , pp. 221-232
    • Sharma, R.P.1    He, Q.2    Meredith, F.I.3    Riley, R.T.4    Voss, K.A.5
  • 48
    • 0037227992 scopus 로고    scopus 로고
    • Deletion of IFN γ reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors
    • R.P. Sharma, Q. He, and V.J. Johnson Deletion of IFN γ reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors J. Interferon Cytokine Res. 23 2003 13 23
    • (2003) J. Interferon Cytokine Res. , vol.23 , pp. 13-23
    • Sharma, R.P.1    He, Q.2    Johnson, V.J.3
  • 50
    • 0037223672 scopus 로고    scopus 로고
    • Low-dose TNF-α protects against hepatic ischemia-reperfusion injury in mice: Implications for preconditioning
    • N. Teoh, I. Leclercq, A.D. Pena, and G. Farrell Low-dose TNF-α protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning Hepatology 37 2003 118 128
    • (2003) Hepatology , vol.37 , pp. 118-128
    • Teoh, N.1    Leclercq, I.2    Pena, A.D.3    Farrell, G.4
  • 53
    • 0031635960 scopus 로고    scopus 로고
    • 1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice
    • 1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice J. Biochem. Mol. Toxicol. 12 1998 281 289
    • (1998) J. Biochem. Mol. Toxicol. , vol.12 , pp. 281-289
    • Tsunoda, M.1    Sharma, R.P.2    Riley, R.T.3
  • 56
    • 0026317132 scopus 로고
    • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
    • E. Wang, W.P. Norred, C.W. Bacon, R.T. Riley, and A.H. Merrill Jr. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme J. Biol. Chem. 266 1991 14486 14490
    • (1991) J. Biol. Chem. , vol.266 , pp. 14486-14490
    • Wang, E.1    Norred, W.P.2    Bacon, C.W.3    Riley, R.T.4    Merrill Jr., A.H.5
  • 57
    • 0026654225 scopus 로고
    • Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme
    • E. Wang, P.F. Ross, T.M. Wilson, R.T. Riley, and A.H. Merrill Jr. Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme J. Nutr. 122 1992 1706 1716
    • (1992) J. Nutr. , vol.122 , pp. 1706-1716
    • Wang, E.1    Ross, P.F.2    Wilson, T.M.3    Riley, R.T.4    Merrill Jr., A.H.5
  • 59
    • 0004296057 scopus 로고    scopus 로고
    • Environmental Health Criteria 219. Fumonisin B1
    • Marasas, W.F.O., Miller, J.D., Riley, R.T., Visconti, A. (Eds.), United Nations Environmental Programme. The International Labour Organization and the World Health Organization. World Health Organization, Geneva, Switzerland
    • WHO (World Health Organization), 2000. Environmental Health Criteria 219. Fumonisin B1. In: Marasas, W.F.O., Miller, J.D., Riley, R.T., Visconti, A. (Eds.), International Programme on Chemical Safety, United Nations Environmental Programme. The International Labour Organization and the World Health Organization. World Health Organization, Geneva, Switzerland, pp. 1-150.
    • (2000) International Programme on Chemical Safety , pp. 1-150
  • 60
    • 0033607517 scopus 로고    scopus 로고
    • Activation of sphingosine kinase by tumor necrosis factor-α inhibits apoptosis in human endothelial cells
    • P. Xia, L. Wang, J.R. Gamble, and M.A. Vadas Activation of sphingosine kinase by tumor necrosis factor-α inhibits apoptosis in human endothelial cells J. Biol. Chem. 274 1999 34499 34505
    • (1999) J. Biol. Chem. , vol.274 , pp. 34499-34505
    • Xia, P.1    Wang, L.2    Gamble, J.R.3    Vadas, M.A.4
  • 61
    • 0033978690 scopus 로고    scopus 로고
    • Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: Role of Kupffer cells and inflammatory cytokines
    • T. Yamano, L.A. DeCicco, and L.E. Rikans Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of Kupffer cells and inflammatory cytokines Toxicol. Appl. Pharmacol. 162 2000 68 75
    • (2000) Toxicol. Appl. Pharmacol. , vol.162 , pp. 68-75
    • Yamano, T.1    Decicco, L.A.2    Rikans, L.E.3
  • 62
    • 0030175768 scopus 로고    scopus 로고
    • Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity
    • H.S. Yoo, W.P. Norred, J. Showker, and R.T. Riley Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity Toxicol. Appl. Pharmacol. 138 1996 211 218
    • (1996) Toxicol. Appl. Pharmacol. , vol.138 , pp. 211-218
    • Yoo, H.S.1    Norred, W.P.2    Showker, J.3    Riley, R.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.